DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and AgaP_AGAP011229

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_309414.4	Gene:	AgaP_AGAP011229 / 1270695	VectorBaseID:	AGAP011229	Length:	398	Species:	Anopheles gambiae

Alignment Length:	401	Identity:	113/401 - (28%)
Similarity:	175/401 - (43%)	Gaps:	60/401 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 WNHCTSGVCRCNPDTKSFT-CWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKE 209
            :..|.| :|.|..|....| |....|..||: |:.| ::..|:|:.|.::.:|..    ||...:
Mosquito    27 YTFCPS-ICTCEGDPNVRTWCIGAGLDVVPI-QLNP-DVRYINLTANRITNVHFT----LTFYYK 84

  Fly   210 LDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFY 274
            |:                     ||.:..|::|.:..|.|...:.|..|:||.|.|..:|:..|.
Mosquito    85 LE---------------------VLDLAGNRIEALGSRNFDTQQALRTLNLSDNAIVSIPKDAFR 128

  Fly   275 HAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAK 339
            ..|||..:.:|.|:|....|....|...|.|||:..|.::.|...::|:|..|:.|.|..||:.:
Mosquito   129 GLQRLQTLKLCGNRIDTIHPAAFHDLRNLIELDLEGNALTSLEPSTLRHLYSLEVLSFQNNQLLE 193

  Fly   340 --------------------------IDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTL 378
                                      |.:|.|..||.||||.|..|.::.|....|:.|:.|..|
Mosquito   194 VPYERNLEHLGQRLQLLDLSVNLLEYIANDSFVALRELRTLRLGGNILTELDYGAFHGLSGLKAL 258

  Fly   379 DLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFS-NNLTTLEADDFQ 442
            |:..|.::.:......:|.||..|.|..|...|:||..|||:..|.:|.|.. :.|..::|..|.
Mosquito   259 DIVDNNLTVVPTLQLSKLCNLTYLSLSGNYFESLPAVAFLNLFQLQQLHLDRLDRLQRIDARAFV 323

  Fly   443 GLNNLKILLLNNN-ILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALH-GLKNLVAVKLDKNPW 505
            ....|:||.|::| ...:...|.|.....|.::.:..|.|:.|  .|:| .|..|..::|..||.
Mosquito   324 DNAALRILTLDDNPSFASLPLRLFHSNPNLAEISMRRNALIRL--DAVHFPLDRLHRLELGGNPL 386

  Fly   506 HCDCRALYLAR 516
            .|:|..|:|.|
Mosquito   387 VCNCSLLWLWR 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	10/58 (17%)
		leucine-rich repeat	187..206	CDD:275380	4/18 (22%)
		LRR_RI	<201..386	CDD:238064	56/210 (27%)
		leucine-rich repeat	207..230	CDD:275380	1/22 (5%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	21/59 (36%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	24/83 (29%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	9/48 (19%)
		LRR_8	349..407	CDD:290566	19/57 (33%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	17/45 (38%)
		leucine-rich repeat	399..422	CDD:275380	10/22 (45%)
		leucine-rich repeat	423..443	CDD:275380	6/20 (30%)
		leucine-rich repeat	471..494	CDD:275380	7/23 (30%)
		LRRCT	503..554	CDD:214507	7/14 (50%)
AgaP_AGAP011229	XP_309414.4	leucine-rich repeat	62..84	CDD:275380	6/25 (24%)
		leucine-rich repeat	85..108	CDD:275380	7/43 (16%)
		LRR_RI	<108..289	CDD:238064	53/180 (29%)
		LRR_8	109..167	CDD:290566	21/57 (37%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		leucine-rich repeat	133..156	CDD:275380	6/22 (27%)
		LRR_8	155..239	CDD:290566	23/83 (28%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		leucine-rich repeat	181..206	CDD:275380	5/24 (21%)
		leucine-rich repeat	207..230	CDD:275380	4/22 (18%)
		LRR_8	229..289	CDD:290566	20/59 (34%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		LRR_8	278..337	CDD:290566	21/58 (36%)
		leucine-rich repeat	279..302	CDD:275380	10/22 (45%)
		leucine-rich repeat	303..324	CDD:275380	6/20 (30%)
		leucine-rich repeat	353..366	CDD:275378	3/12 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910