DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and AgaP_AGAP007471

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_308401.2	Gene:	AgaP_AGAP007471 / 1269752	VectorBaseID:	AGAP007471	Length:	406	Species:	Anopheles gambiae

Alignment Length:	378	Identity:	82/378 - (21%)
Similarity:	154/378 - (40%)	Gaps:	76/378 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 PVTQVIPMN-MVNIDLSRNI-LSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQ--DLDSLLV- 233
            ||.|:...| :..|::...: |.:|...|.|.||   .|.:.:.:||.:|..|..  :|:.||:
Mosquito    58 PVFQLPADNTLTEIEIVNGVMLRSLVAGTNRHLT---RLYVENCLLDRIPPTLSNMIELEGLLIK 119

  Fly   234 ------LRIQ---NNQLEDIDHRTFWKLRNLNILDLSKNEIGML------PESIFYHAQRLTVIN 283
                  ||:.   ||.             .|..:||::|.|..|      |::    ...:|.::
Mosquito   120 QCALTALRLDVLVNNP-------------KLTAIDLTRNRIRQLFPITTPPKT----KLPVTFLS 167

  Fly   284 MCDNQIQNFPPNLLRDQLMLEELDMSRNKISEL-SSGSIRYLTKLKTLDFGWNQIAKIDDDFFAG 347
            :.:||:.....::......||..::..|:|... ::..:.|.:.::.| ...|.|.:.|.....
Mosquito   168 LAENQLDRLDMSMFAFMPDLERFNVEGNRIVRFEATAPVTYGSLIRLL-VSSNNITQFDTRNLT- 230

  Fly   348 LRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSI 412
            |..||:|.:::|.::.|. |.:..|.||:.:....|.:..||.:.|.:...|..:.:.:|::.||
Mosquito   231 LTELRSLYINDNALTELP-THWGKLPNLIYIGFDRNNLKRIDMSFFEKFPTLISITISENNVESI 294

  Fly   413 PADLFLNVSALTRLTLFSNNLTTLEADDFQGLN--NLKILLLNNNILKNFDARAFEPLSQLEKLR 475
            .....:.:..|..|....|.:.::   :|.|.|  |:.:....||.|     ....||.|    |
Mosquito   295 RTSTPITMPELEYLMFNGNQIVSV---NFTGCNFPNMYLFSFMNNRL-----TTIPPLFQ----R 347

  Fly   476 IDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDG 528
            ...::|                 .:|.||..|....::.:: |.::.|.:..|
Mosquito   348 FPDSRL-----------------AMDGNPIKCSSMTVFKSK-ITDYRLHVTTG 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/72 (28%)
		leucine-rich repeat	187..206	CDD:275380	5/19 (26%)
		LRR_RI	<201..386	CDD:238064	45/203 (22%)
		leucine-rich repeat	207..230	CDD:275380	6/24 (25%)
		leucine-rich repeat	231..254	CDD:275380	6/32 (19%)
		LRR_8	253..313	CDD:290566	13/65 (20%)
		leucine-rich repeat	255..278	CDD:275380	7/28 (25%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	14/58 (24%)
		leucine-rich repeat	303..326	CDD:275380	5/23 (22%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	14/57 (25%)
		LRR_4	350..390	CDD:289563	11/39 (28%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	8/44 (18%)
		leucine-rich repeat	399..422	CDD:275380	4/22 (18%)
		leucine-rich repeat	423..443	CDD:275380	4/19 (21%)
		leucine-rich repeat	471..494	CDD:275380	2/22 (9%)
		LRRCT	503..554	CDD:214507	6/26 (23%)
AgaP_AGAP007471	XP_308401.2	LRR_8	88..147	CDD:290566	19/74 (26%)
		leucine-rich repeat	90..112	CDD:275380	7/24 (29%)
		leucine-rich repeat	113..136	CDD:275380	7/35 (20%)
		LRR_8	135..197	CDD:290566	13/78 (17%)
		leucine-rich repeat	137..160	CDD:275380	7/26 (27%)
		leucine-rich repeat	161..186	CDD:275380	3/24 (13%)
		leucine-rich repeat	187..210	CDD:275380	5/22 (23%)
		leucine-rich repeat	211..233	CDD:275380	5/23 (22%)
		LRR_8	232..291	CDD:290566	15/59 (25%)
		leucine-rich repeat	234..256	CDD:275380	7/22 (32%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		leucine-rich repeat	281..304	CDD:275380	4/22 (18%)
		leucine-rich repeat	305..327	CDD:275380	6/24 (25%)
		leucine-rich repeat	328..350	CDD:275380	7/30 (23%)
		leucine-rich repeat	351..370	CDD:275380	5/35 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910