DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7509 and LRRK2

DIOPT Version :9

Sequence 1:NP_647931.1 Gene:CG7509 / 38579 FlyBaseID:FBgn0035575 Length:615 Species:Drosophila melanogaster
Sequence 2:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens


Alignment Length:381 Identity:97/381 - (25%)
Similarity:164/381 - (43%) Gaps:77/381 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   190 RNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDID--------- 245
            |.|||:  .|:.|...:...:..|.::     ..|..:.:.:..|.:..|:|.|||         
Human   950 RKILSS--DDSLRSSKLQSHMRHSDSI-----SSLASEREYITSLDLSANELRDIDALSQKCCIS 1007

  Fly   246 -HRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMS 309
             |     |.:|..|:|.:|.:...|:.:....:.||.:::..|:..:||..||: ...:..||:|
Human  1008 VH-----LEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLK-MSCIANLDVS 1066

  Fly   310 RNKI--SELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNL 372
            ||.|  |.:...:::..| ||..:..:||::.:.::....:..|..|.|..|:||.:...:  .|
Human  1067 RNDIGPSVVLDPTVKCPT-LKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPL--RL 1128

  Fly   373 ANLVTLDLTTNRISHIDGNAFVE-----------LN----------NLNELFLGQNSMSSIPADL 416
            ..|..|:|:.|.||.:..| |:|           :|          ::..|.|.||..|.|| :.
Human  1129 KELKILNLSKNHISSLSEN-FLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIP-EA 1191

  Fly   417 FLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPL-SQLEKLRIDSNK 480
            .||:..|..|.:.||::..|.........||:.||.::|.:...|......| |::|||.:..||
Human  1192 ILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNK 1256

  Fly   481 LMFLPH--GALHGLKNL-VAVKLDKNPWHCDCRALYLARWIREF------VLKLWD 527
            |..:|.  |.|..|.:| |:..|:                :|.|      :.|:||
Human  1257 LKEIPPEIGCLENLTSLDVSYNLE----------------LRSFPNEMGKL
SKIWD 1296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7509NP_647931.1 LRR_8 182..241 CDD:290566 10/50 (20%)
leucine-rich repeat 187..206 CDD:275380 6/15 (40%)
LRR_RI <201..386 CDD:238064 46/196 (23%)
leucine-rich repeat 207..230 CDD:275380 2/22 (9%)
leucine-rich repeat 231..254 CDD:275380 8/32 (25%)
LRR_8 253..313 CDD:290566 17/59 (29%)
leucine-rich repeat 255..278 CDD:275380 5/22 (23%)
leucine-rich repeat 279..302 CDD:275380 7/22 (32%)
LRR_8 303..361 CDD:290566 16/59 (27%)
leucine-rich repeat 303..326 CDD:275380 7/24 (29%)
leucine-rich repeat 327..350 CDD:275380 4/22 (18%)
LRR_8 349..407 CDD:290566 19/78 (24%)
LRR_4 350..390 CDD:289563 13/39 (33%)
leucine-rich repeat 351..374 CDD:275380 7/22 (32%)
leucine-rich repeat 375..398 CDD:275380 10/43 (23%)
LRR_8 398..>443 CDD:290566 14/44 (32%)
leucine-rich repeat 399..422 CDD:275380 9/22 (41%)
leucine-rich repeat 423..443 CDD:275380 5/19 (26%)
leucine-rich repeat 471..494 CDD:275380 10/24 (42%)
LRRCT 503..554 CDD:214507 5/31 (16%)
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969 6/20 (30%)
LRR 1 983..1004 6/20 (30%)
leucine-rich repeat 985..1012 CDD:275380 8/31 (26%)
LRR 1012..>1286 CDD:227223 78/295 (26%)
LRR 2 1012..1033 5/20 (25%)
leucine-rich repeat 1013..1036 CDD:275380 5/22 (23%)
LRR 3 1036..1057 7/21 (33%)
leucine-rich repeat 1037..1084 CDD:275380 14/47 (30%)
LRR 4 1059..1080 7/20 (35%)
LRR 5 1084..1105 5/21 (24%)
leucine-rich repeat 1085..1108 CDD:275380 4/22 (18%)
LRR 6 1108..1129 6/22 (27%)
leucine-rich repeat 1109..1130 CDD:275380 7/22 (32%)
LRR 7 1130..1150 8/20 (40%)
leucine-rich repeat 1131..1174 CDD:275380 10/43 (23%)
LRR 8 1174..1196 9/22 (41%)
leucine-rich repeat 1175..1197 CDD:275380 9/22 (41%)
LRR 9 1197..1218 5/20 (25%)
leucine-rich repeat 1198..1221 CDD:275380 5/22 (23%)
LRR 10 1221..1241 6/19 (32%)
leucine-rich repeat 1222..1246 CDD:275380 6/23 (26%)
LRR 11 1246..1267 8/20 (40%)
leucine-rich repeat 1247..1269 CDD:275380 9/21 (43%)
LRR 12 1269..1291 6/37 (16%)
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:318343
STKc_LRRK2 1884..2135 CDD:270970
WD 1 2139..2183
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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