DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and CHAD

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_011522516.1	Gene:	CHAD / 1101	HGNCID:	1909	Length:	440	Species:	Homo sapiens

Alignment Length:	394	Identity:	94/394 - (23%)
Similarity:	154/394 - (39%)	Gaps:	86/394 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 CRCNPDTKSFTCWNTNLKSVP-VTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVL 217
            |.|:.|.:...|....|:.:| |::...:    ::|.||....|..::||.
Human   108 CHCHSDLQHVICDKVGLQKIPKVSEKTKL----LNLQRNNFPVLAANSFRA-------------- 154

  Fly   218 DFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVI 282
                      :.:|:.|.:|:.|:.::....|..|:.|..|.||.|:|.:|....|.....||.:
Human   155 ----------MPNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYL 209

  Fly   283 NMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAG 347
            .:..|::...|..||...:.|..|.::.|||.||.:|:                        |.|
Human   210 YLDHNKVTELPRGLLSPLVNLFILQLNNNKIRELRAGA------------------------FQG 250

  Fly   348 LRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSI 412
            .:.||.|.|..|.:|||.....:::.||....:..|::|.....|..:|..:.||.|..|.:.||
Human   251 AKDLRWLYLSENALSSLQPGALDDVENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSI 315

  Fly   413 PADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRID 477
            |.:.|.:         |...|.|              |.|:|..|:.|...||..::.|:.:.::
Human   316 PDNAFQS---------FGRYLET--------------LWLDNTNLEKFSDGAFLGVTTLKHVHLE 357

  Fly   478 SNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQP--MCRGPGDLG 540
            :|:|..||..  ....:|..:.|..|||.|.|:...|.||:..      ...:|  .|..|....
Human   358 NNRLNQLPSN--FPFDSLETLALTNNPWKCTCQLRGLRRWLEA------KASRPDATCASPAKFK 414

  Fly   541 GHEV 544
            |..:
Human   415 GQHI 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	9/58 (16%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	43/184 (23%)
		leucine-rich repeat	207..230	CDD:275380	0/22 (0%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	17/59 (29%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	15/57 (26%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	2/22 (9%)
		LRR_8	349..407	CDD:290566	17/57 (30%)
		LRR_4	350..390	CDD:289563	12/39 (31%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	5/22 (23%)
		LRR_8	398..>443	CDD:290566	11/44 (25%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	5/22 (23%)
		LRRCT	503..554	CDD:214507	12/44 (27%)
CHAD	XP_011522516.1	LRRNT	104..130	CDD:279764	6/21 (29%)
		leucine-rich repeat	134..157	CDD:275380	6/50 (12%)
		LRR_8	156..216	CDD:290566	17/59 (29%)
		leucine-rich repeat	158..181	CDD:275380	6/22 (27%)
		LRR_RI	<171..363	CDD:238064	61/238 (26%)
		leucine-rich repeat	182..205	CDD:275380	8/22 (36%)
		LRR_8	204..264	CDD:290566	21/83 (25%)
		leucine-rich repeat	206..229	CDD:275380	6/22 (27%)
		leucine-rich repeat	230..253	CDD:275380	10/46 (22%)
		leucine-rich repeat	254..277	CDD:275380	8/22 (36%)
		leucine-rich repeat	278..301	CDD:275380	5/22 (23%)
		LRR_8	302..361	CDD:290566	20/81 (25%)
		leucine-rich repeat	302..325	CDD:275380	9/31 (29%)
		leucine-rich repeat	327..350	CDD:275380	9/36 (25%)
		leucine-rich repeat	351..373	CDD:275380	5/23 (22%)
		LRRCT	381..428	CDD:214507	12/44 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840