DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and LRRN2

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_006329.2	Gene:	LRRN2 / 10446	HGNCID:	16914	Length:	713	Species:	Homo sapiens

Alignment Length:	480	Identity:	119/480 - (24%)
Similarity:	174/480 - (36%)	Gaps:	132/480 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 PV--WHLATGSQIEWNHCTSGVCRCNP---------DTKSFTCWNTNLKSVPV-----TQVIPM- 181
            ||  ||:....|     |   .|:..|         :..:..|.:..|.:||.     ||.:.:
Human    21 PVVPWHVPCPPQ-----C---ACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQTLLLQ 77

  Fly   182 ----------------NMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDS 230
                            |:..:|||:|..|......|..|..|..|.:..|.|..|....|..|.|
Human    78 SNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLAS 142

  Fly   231 LLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPN 295
            |..|.:.:|||..|..|.|..|.||..|.|:.|                 ::...|::.....||
Human   143 LQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSN-----------------LLRAIDSRWFEMLPN 190

  Fly   296 LLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNR 360
                   ||.|.:..||:..:...:.|.|..|::|......:.:|.|....||:||.:||.::|:
Human   191 -------LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQ 248

  Fly   361 ISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMS---SIPADLFLNVSA 422
            ::.:.......:..|..|||..|.:..:....|..:.:|.|  ||.|:|.   ||.....:|:..
Human   249 LARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKE--LGLNNMEELVSIDKFALVNLPE 311

  Fly   423 LTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHG 487
            ||:|.                       :.||..|.....|||..|.|:|.|.:::|.|..|...
Human   312 LTKLD-----------------------ITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQ 353

  Fly   488 ALHGLKNLVAVKLDKNPWHCDCRALYLARWIR------EFVLKLWDGQQPMCRGPGDLGGHEVGL 546
            .:..|.||..|.|..||..|||    :.||..      .|:    :.|..:|..|.||
Human   354 TVESLPNLQEVGLHGNPIRCDC----VIRWANATGTRVRFI----EPQSTLCAEPPDL------- 403

  Fly   547 LRYDDLCDGQWASMLSLSPRLPVRK 571
                              .|||||:
Human   404 ------------------QRLPVRE 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	19/58 (33%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	50/184 (27%)
		leucine-rich repeat	207..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	12/59 (20%)
		leucine-rich repeat	255..278	CDD:275380	4/22 (18%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	303..361	CDD:290566	18/57 (32%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR_8	349..407	CDD:290566	15/57 (26%)
		LRR_4	350..390	CDD:289563	10/39 (26%)
		leucine-rich repeat	351..374	CDD:275380	4/22 (18%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	12/47 (26%)
		leucine-rich repeat	399..422	CDD:275380	9/25 (36%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		LRRCT	503..554	CDD:214507	13/56 (23%)
LRRN2	NP_006329.2	leucine-rich repeat	51..69	CDD:275380	4/17 (24%)
		LRR_RI	62..288	CDD:238064	61/249 (24%)
		LRR 1	70..91		2/20 (10%)
		leucine-rich repeat	71..94	CDD:275380	2/22 (9%)
		LRR 2	94..115		7/20 (35%)
		leucine-rich repeat	95..118	CDD:275380	7/22 (32%)
		LRR_8	117..177	CDD:290566	22/76 (29%)
		LRR 3	118..139		6/20 (30%)
		leucine-rich repeat	119..142	CDD:275380	7/22 (32%)
		LRR 4	142..163		9/20 (45%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR_8	165..222	CDD:290566	17/80 (21%)
		LRR 5	166..187		6/37 (16%)
		leucine-rich repeat	167..190	CDD:275380	5/39 (13%)
		LRR 6	190..211		6/27 (22%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		LRR_RI	209..>372	CDD:238064	51/187 (27%)
		LRR_8	214..273	CDD:290566	16/58 (28%)
		LRR 7	214..235		4/20 (20%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		LRR 8	238..259		5/20 (25%)
		leucine-rich repeat	239..262	CDD:275380	4/22 (18%)
		LRR 9	262..283		6/20 (30%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		LRR 10	286..305		8/20 (40%)
		leucine-rich repeat	287..311	CDD:275380	9/25 (36%)
		LRR_8	310..371	CDD:290566	22/83 (27%)
		LRR 11	311..333		9/44 (20%)
		leucine-rich repeat	312..334	CDD:275380	9/44 (20%)
		LRR 12	336..357		6/20 (30%)
		leucine-rich repeat	337..360	CDD:275378	6/22 (27%)
		leucine-rich repeat	361..373	CDD:275378	5/11 (45%)
		TPKR_C2	369..412	CDD:301599	18/75 (24%)
		I-set	430..514	CDD:254352
		Ig	438..514	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910