DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and LOC101884430

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_021325136.1	Gene:	LOC101884430 / 101884430	-ID:	-	Length:	635	Species:	Danio rerio

Alignment Length:	495	Identity:	138/495 - (27%)
Similarity:	216/495 - (43%)	Gaps:	69/495 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 TKSFTCW--NTNLKSVPVTQVIPMN-MVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLP 221
            ||:|...  :||:|.:.......:: ::.:.::.:.|.|:..:.|.|...|:.:.:|.|.|..:|
Zfish    47 TKTFLLLLNDTNIKVLKDRSFQQLSLLLRVMITHSTLDTIQPEAFHGAPQLRSIKMSSNALAVVP 111

  Fly   222 FDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCD 286
            ..:|.:..:|..|::..||:..:....|..|.::..||||||.|..|...:|....:|..:|:..
Zfish   112 PKVFIEQRNLEQLQLDGNQIVSVSSELFEGLVSMTELDLSKNRISQLDAGVFQSLTKLIYLNLAG 176

  Fly   287 NQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSL 351
            ||::|.|..:..:...|:.|.::.|.:..|.|||..:|:.|..|....|||.:|....|..:.||
Zfish   177 NQLRNLPKTVFHNLGNLQTLVLTSNHLEILESGSFDHLSNLLVLMLQKNQIREIPPRLFWHMPSL 241

  Fly   352 RTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADL 416
            .|||:.||::..:....|..|.||..|.|..|.:..:.......:..|.||:|.:.::.::|::|
Zfish   242 LTLSMSNNQLQHIPPESFYYLPNLTKLTLYKNPLIFLPDQLIGHMPRLQELYLYETNLVTVPSNL 306

  Fly   417 FLNVS-------------------------ALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNI 456
            |.|.:                         .|.:|:|..|||..|..:.|..||.|:||.|:.|.
Zfish   307 FANTTNLQYLNVHLNSNLTLLPKDVFCCLPNLRKLSLKHNNLRELHPEIFSNLNRLQILTLDGNK 371

  Fly   457 LKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIRE- 520
            .::..:..|...|:||.|.::.|.|.|||.........|..:.|..|.|.|||..|..|.|||:
Zfish   372 FESLPSTIFLNTSRLEILNLNQNHLRFLPGDVFVHAGALKVLTLSDNRWMCDCSILGFAEWIRDN 436

  Fly   521 --FVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLCDG----QWASM-----------LSLSPRL- 567
              .:..|.:|  ..|..|..|..|.:..|.|.||..|    |...|           :|..|||
Zfish   437 WRMISDLDNG--VACYEPNYLQNHLLQTLTYKDLQCGLSVLQTTLMTNINTFTVPILMSTIPRLI 499

  Fly   568 --------------PVRKHQISTPMNY------TDYFNLY 587
                          ||...|:|...||      .||:|.|
Zfish   500 STTSREATETTSPFPVVTSQVSPTSNYIFIKEGIDYYNDY 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	13/59 (22%)
		leucine-rich repeat	187..206	CDD:275380	4/18 (22%)
		LRR_RI	<201..386	CDD:238064	58/184 (32%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	6/22 (27%)
		LRR_8	253..313	CDD:290566	18/59 (31%)
		leucine-rich repeat	255..278	CDD:275380	9/22 (41%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	22/57 (39%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	18/57 (32%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	4/22 (18%)
		LRR_8	398..>443	CDD:290566	16/69 (23%)
		leucine-rich repeat	399..422	CDD:275380	8/47 (17%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	20/53 (38%)
LOC101884430	XP_021325136.1	LRR_8	52..107	CDD:316378	10/54 (19%)
		leucine-rich repeat	52..72	CDD:275380	3/19 (16%)
		leucine-rich repeat	73..96	CDD:275380	4/22 (18%)
		NEL	<92..>362	CDD:330839	75/269 (28%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		leucine-rich repeat	193..216	CDD:275380	8/22 (36%)
		leucine-rich repeat	217..240	CDD:275380	7/22 (32%)
		leucine-rich repeat	241..264	CDD:275380	8/22 (36%)
		leucine-rich repeat	265..288	CDD:275380	4/22 (18%)
		leucine-rich repeat	289..312	CDD:275380	8/22 (36%)
		leucine-rich repeat	313..335	CDD:275380	0/21 (0%)
		LRR_8	336..396	CDD:316378	21/59 (36%)
		leucine-rich repeat	338..359	CDD:275380	8/20 (40%)
		leucine-rich repeat	362..385	CDD:275380	6/22 (27%)
		leucine-rich repeat	386..406	CDD:275380	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D595054at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.970