DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lrfn4a

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_005161420.1	Gene:	lrfn4a / 101882983	ZFINID:	ZDB-GENE-091113-56	Length:	892	Species:	Danio rerio

Alignment Length:	345	Identity:	85/345 - (24%)
Similarity:	140/345 - (40%)	Gaps:	67/345 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 MCDNQIQNF-PPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAG 347
            :|.|:...| |||:.|..:   ||.::.|.|.|:....                        ||.
Zfish    97 LCVNKGLLFVPPNIDRRTV---ELRLADNYILEVGGAD------------------------FAN 134

  Fly   348 LRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSI 412
            :..|..|:|..|.|.:|....|.:|.:|.:|.|.|||::.:.......|.||..|.:..|.::.:
Zfish   135 MTGLVDLTLSRNTIHALKPLAFADLESLRSLHLDTNRLTVVGPQDLTGLVNLQHLIINNNQLTDV 199

  Fly   413 PADLFLN-VSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPLSQLEKLRI 476
            .||.|.: :..|..|.|..|||..:..:..|.:.:|..|.|::|::......:|..|.:|.:|.:
Zfish   200 SADAFDDFLLTLEDLDLSYNNLRRVPWESIQNMASLHTLNLDHNLIDQIAEGSFGELYKLSRLDM 264

  Fly   477 DSNKLMFLPHGALHG-----------LKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQ 530
            .||:|..||...|..           ..::.::....||.||:|..|:|.|.|||       ...
Zfish   265 TSNRLQTLPPDPLFSRSQIGVVSPTPYNSITSLNFGGNPLHCNCELLWLRRLIRE-------DDM 322

  Fly   531 PMCRGPGDLGGHEVGLLRYDD----------------LCDGQWASM--LSLSPRLPVRKHQISTP 577
            ..|..|..|.|.....:..::                :.:||.|::  .::....|| .|.:| |
Zfish   323 ETCATPAHLAGRYFWSIPEEEFTCEPPLITRNTNKLWVLEGQRATLKCRAIGDPEPV-IHWVS-P 385

  Fly   578 MNYTDYFNLYLKHIYNGTTD 597
            .:.....:..::..||||.|
Zfish   386 DDRIVANSSRIRSYYNGTLD 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566
		leucine-rich repeat	187..206	CDD:275380
		LRR_RI	<201..386	CDD:238064	28/102 (27%)
		leucine-rich repeat	207..230	CDD:275380
		leucine-rich repeat	231..254	CDD:275380
		LRR_8	253..313	CDD:290566	10/29 (34%)
		leucine-rich repeat	255..278	CDD:275380
		leucine-rich repeat	279..302	CDD:275380	7/18 (39%)
		LRR_8	303..361	CDD:290566	11/57 (19%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	2/22 (9%)
		LRR_8	349..407	CDD:290566	18/57 (32%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	13/45 (29%)
		leucine-rich repeat	399..422	CDD:275380	6/23 (26%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	8/33 (24%)
		LRRCT	503..554	CDD:214507	15/66 (23%)
lrfn4a	XP_005161420.1	LRR_RI	102..>269	CDD:238064	51/193 (26%)
		leucine-rich repeat	114..137	CDD:275380	7/49 (14%)
		LRR_8	136..196	CDD:290566	19/59 (32%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	185..245	CDD:290566	18/59 (31%)
		leucine-rich repeat	186..210	CDD:275380	6/23 (26%)
		leucine-rich repeat	211..234	CDD:275380	7/22 (32%)
		LRR_8	234..304	CDD:290566	15/69 (22%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		leucine-rich repeat	259..282	CDD:275380	8/22 (36%)
		LRRCT	302..346	CDD:214507	15/50 (30%)
		IG_like	358..436	CDD:214653	13/50 (26%)
		Ig	363..436	CDD:299845	13/45 (29%)
		fn3	501..579	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000