DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and Chadl

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_038936217.1	Gene:	Chadl / 100910434	RGDID:	6504353	Length:	747	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	128/502 - (25%)
Similarity:	179/502 - (35%)	Gaps:	126/502 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 MPNGTQSAANDKKPPKSKANGHNDGDVNGGEINAMSHLANFDLVKRVRQIESRLRSVEQPVWHLA 139
            ||:|.|.:.:..:|                        .:|.|:        .|.....|.|::|
  Rat     1 MPHGQQLSLSSPRP------------------------QSFTLL--------LLMMFLSPAWNVA 33

  Fly   140 TGSQIEWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGL 204
            .      ..|.. .|.|:...:..||.:.||..||                        ||...|
  Rat    34 A------QRCPQ-TCVCDNSRRHVTCQHQNLTEVP------------------------DTIPEL 67

  Fly   205 TVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLP 269
            |  :.||:..|:|..:|...||||..|..|.:|:.|:|.:                        .
  Rat    68 T--QRLDLQGNMLKVIPPAAFQDLPYLTHLDLQHCQVEQV------------------------A 106

  Fly   270 ESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGW 334
            |..|....||..:|:..|::.:.|...|.....|..|::.||.:.||..|:
  Rat   107 EGAFRGLGRLLFLNLASNRLSSLPQEALDGLGSLRRLELERNMLEELRPGT-------------- 157

  Fly   335 NQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVELNNL 399
                      |..|.||.||:|.:|.:..|....|..|.....|.|:.|.:|.:...|...|..|
  Rat   158 ----------FGALGSLATLNLAHNALVYLPAMAFQGLMRTRWLQLSHNALSVLAPEALAGLPVL 212

  Fly   400 NELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARA 464
            ..|.|..|.:.::|........:|.||.|..|.||....:|...|..|:.|.|::..|:....||
  Rat   213 RRLSLHHNELQALPGAALSQARSLARLELGHNPLTYTGEEDGLALPGLRELALDHGSLQALGPRA 277

  Fly   465 FEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARW-IREFVLKLWDG 528
            |....:|..|.:..|:|..||...:.|  .|..::|..||..|.|.|..|..| :|..|..  ||
  Rat   278 FAHCPRLHTLDLRGNQLTTLPPLQVPG--QLRRLRLQGNPLWCACHARPLLEWLVRARVRS--DG 338

  Fly   529 QQPMCRGPGDLGGHEVGLLRYDDL-CDGQWA----SMLSLSPRLPVR 570
               .||||..|.|..:..||..|| |.|..|    ......||.|.|
  Rat   339 ---ACRGPRRLRGETLDTLRPSDLRCPGDAAEDEDEDRPAGPRSPPR 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	16/58 (28%)
		leucine-rich repeat	187..206	CDD:275380	3/18 (17%)
		LRR_RI	<201..386	CDD:238064	45/184 (24%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR_8	253..313	CDD:290566	12/59 (20%)
		leucine-rich repeat	255..278	CDD:275380	2/22 (9%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	15/57 (26%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	2/22 (9%)
		LRR_8	349..407	CDD:290566	18/57 (32%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	8/22 (36%)
		leucine-rich repeat	375..398	CDD:275380	6/22 (27%)
		LRR_8	398..>443	CDD:290566	13/44 (30%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	21/52 (40%)
Chadl	XP_038936217.1	PLN00113	30..>555	CDD:215061	119/441 (27%)
		leucine-rich repeat	48..66	CDD:275380	8/41 (20%)
		leucine-rich repeat	68..91	CDD:275380	10/24 (42%)
		leucine-rich repeat	92..115	CDD:275380	7/46 (15%)
		leucine-rich repeat	116..139	CDD:275380	5/22 (23%)
		leucine-rich repeat	140..163	CDD:275380	9/46 (20%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..211	CDD:275380	6/22 (27%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..259	CDD:275380	9/22 (41%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		leucine-rich repeat	306..345	CDD:275380	17/43 (40%)
		leucine-rich repeat	425..448	CDD:275380
		PPP1R42	446..603	CDD:411060
		leucine-rich repeat	449..472	CDD:275380
		leucine-rich repeat	473..496	CDD:275380
		leucine-rich repeat	497..520	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..568	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		LRR_8	591..653	CDD:404697
		leucine-rich repeat	593..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	643..665	CDD:275380
		leucine-rich repeat	666..677	CDD:275378
		LRRCT	673..721	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840