DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and nrros

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001231915.1	Gene:	nrros / 100498580	XenbaseID:	XB-GENE-986206	Length:	679	Species:	Xenopus tropicalis

Alignment Length:	463	Identity:	119/463 - (25%)
Similarity:	181/463 - (39%)	Gaps:	127/463 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 CWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLD 229
            |.:..|.|||  |.:|.::..:.|..|.:..|||::|.....|..|.:..|.::|:....|..:.
Frog    43 CSHLQLLSVP--QNLPTDIQELLLDFNQIRFLHKNSFLRYHDLTNLSLRSNRMEFVEPGAFNGIR 105

  Fly   230 SLLVLRIQNNQLEDIDHRTFWKLR---NLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQN 291
            ||.||.:|||.:......|...||   :|..||||:|.:.|...|:.:  |.||
Frog   106 SLKVLSLQNNTISMEYELTSAALRLTPSLKELDLSRNMLTMDMVSVLH--QNLT----------- 157

  Fly   292 FPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSL 356
                      .||.|.:..|.|..|.......|..||.|...||.|.:|:|..|.||..|:.|.|
Frog   158 ----------SLERLFLDNNIIMRLDQTVFEGLVHLKELSLQWNYIYEIEDGTFEGLVKLKKLDL 212

  Fly   357 HNN--------RISSLS--GTIFNNLA-----------NLVTLDLTTNRISHIDGNAFVEL---- 396
            ..|        |::.:.  ...||||.           :|..||::.|::      .|..|
Frog   213 AYNLLPCIGDFRLTQIQMLNLSFNNLEWFQSQETDVEFHLEILDISNNQL------LFFPLLPRQ 271

  Fly   397 NNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFD 461
            :.|:.|.|..|.| ....|:|...::.....:..||:|::...|          |.:::|..|
Frog   272 HRLHTLLLSNNRM-RFYGDIFGTNTSRADFLIVENNITSVTTVD----------LWSDDIHSN-- 323

  Fly   462 ARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREF----- 521
                  ||.|..|.:..|:..|.|||....:.:|..:||:   |:|          ::.|
Frog   324 ------LSTLHYLDMSHNQFAFFPHGFFSNMSSLAYLKLN---WNC----------LQVFSVSPS 369

  Fly   522 -VLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLCDGQWASMLSLSPRLPVRKHQISTPMNYTDYFN 585
             :..|.|..        ||..:|:..|:.|::..|    :||||                  |||
Frog   370 NITSLLDEL--------DLSNNELLELQADNISPG----ILSLS------------------YFN 404

  Fly   586 LYLKHIYN 593
            |...::||
Frog   405 LSSNNLYN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/58 (31%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	58/208 (28%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		leucine-rich repeat	231..254	CDD:275380	9/25 (36%)
		LRR_8	253..313	CDD:290566	16/62 (26%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	2/22 (9%)
		LRR_8	303..361	CDD:290566	22/65 (34%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	11/22 (50%)
		LRR_8	349..407	CDD:290566	18/82 (22%)
		LRR_4	350..390	CDD:289563	13/60 (22%)
		leucine-rich repeat	351..374	CDD:275380	9/43 (21%)
		leucine-rich repeat	375..398	CDD:275380	6/26 (23%)
		LRR_8	398..>443	CDD:290566	11/44 (25%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	4/19 (21%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		LRRCT	503..554	CDD:214507	10/56 (18%)
nrros	NP_001231915.1	leucine-rich repeat	39..58	CDD:275380	7/16 (44%)
		leucine-rich repeat	59..82	CDD:275380	6/22 (27%)
		LRR_8	60..115	CDD:404697	16/54 (30%)
		leucine-rich repeat	83..106	CDD:275380	5/22 (23%)
		leucine-rich repeat	107..133	CDD:275380	9/25 (36%)
		internalin_A	108..>495	CDD:380193	99/396 (25%)
		leucine-rich repeat	134..158	CDD:275380	11/46 (24%)
		leucine-rich repeat	159..182	CDD:275380	7/22 (32%)
		leucine-rich repeat	183..206	CDD:275380	11/22 (50%)
		leucine-rich repeat	207..227	CDD:275380	5/19 (26%)
		leucine-rich repeat	228..251	CDD:275380	4/22 (18%)
		leucine-rich repeat	274..326	CDD:275380	15/70 (21%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		leucine-rich repeat	351..374	CDD:275380	6/35 (17%)
		leucine-rich repeat	375..399	CDD:275380	7/35 (20%)
		leucine-rich repeat	400..421	CDD:275380	8/31 (26%)
		leucine-rich repeat	424..457	CDD:275380
		leucine-rich repeat	458..480	CDD:275380
		leucine-rich repeat	481..503	CDD:275380
		leucine-rich repeat	504..526	CDD:275380
		leucine-rich repeat	527..548	CDD:275380
		leucine-rich repeat	574..586	CDD:275378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910