DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and slitrk4

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_004916941.2	Gene:	slitrk4 / 100497316	XenbaseID:	XB-GENE-983538	Length:	851	Species:	Xenopus tropicalis

Alignment Length:	621	Identity:	142/621 - (22%)
Similarity:	234/621 - (37%)	Gaps:	205/621 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 PVWHLATGSQIEWNHCTSGVCRC----------------------NPDTKSFTCWN--TNLKSV- 173
            |:......|::....|  .||.|                      .|...:|...|  .||..:
Frog    27 PISSTNPDSELSLEIC--NVCSCLSVENVMYVNCEKVALYRPNQLKPPPSNFYHLNFQNNLLIIL 89

  Fly   174 -PVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQ 237
             |.|.:...:.|::.|..|.|..:....|:||:.||:|.:::|.|..|..|.|..:::|..|:..
Frog    90 YPNTFLNFTHAVSLQLGNNKLQNIEGGAFQGLSALKQLHLNNNELKVLRADTFLGIENLEYLQAD 154

  Fly   238 NNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFP--------- 293
            .|.::.|:...|.||..|.:|.|:.|.|..||::||..|. ||.:::..|:||..|
Frog   155 YNLIKYIERGAFNKLHKLKVLILNDNLISALPDNIFRFAS-LTHLDIRGNRIQKMPYIGVLEHIG 218

  Fly   294 ----------P-----NLLRDQLMLEEL-----------------------DMSRNKISELSSGS 320
                      |     :||..:..||.:                       :.::.::..:.:||
Frog   219 RVVELQLEDNPWNCTCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLLKETNKQELCSMGTGS 283

  Fly   321 ---------------------------IRYLTKL-KTLDFGWNQIAKIDDDFFAGLRSLRTLSLH 357
                                       .|.:||. ||.:...|          :|:.|.:::|.|
Frog   284 DFDVRILPPSMETTFTTPGGQPAQTSLHRLVTKAPKTTNPSKN----------SGIVSGKSVSNH 338

  Fly   358 N--------NRISSLS---------------GTIFN-------NLANLV-------TLDLTTNRI 385
            :        .||...|               |...|       ::|.|:       .|.:..|.|
Frog   339 SLSQIVSFQTRIPPFSPCPSPCMCKTYPSDLGLSVNCQERNIKSMAELIPKPLNAKKLHVNGNYI 403

  Fly   386 SHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLN----- 445
            .|::.:.||:...|:.|.||.|.:::|..::|.|::.|.||.|..|.:..|..:.|.||:
Frog   404 KHVEQSDFVDFEGLDLLHLGSNQLTNIQGNVFCNLTNLRRLYLNGNQIERLSPEIFAGLHNLQYL 468

  Fly   446 -------------------NLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLP-HGALH 490
                               ||::|.||||:|::..|..|..: .|.:|.|.:|..|:|| .|.|.
Frog   469 YLEYNIIKEILGGTFESMPNLQLLYLNNNLLRSLPAYIFSGV-PLARLNIRNNHFMYLPVSGVLD 532

  Fly   491 GLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDG---QQPMCRGPGDLGGHEVGLLRYDDL 552
            .|::|..:.|:.|||.|.|..:.|..|:.    ||.:|   ::..|..|......|:..|:.:.|
Frog   533 QLRSLTQIDLEGNPWDCTCDLVALKLWLE----KLSEGIVMKEVKCETPVQFANIELRSLKNEIL 593

  Fly   553 CDGQWASMLSLSPRL----------PVRKHQISTPM 578
            |           |:|          ||.....:||:
Frog   594 C-----------PKLINKPPTQYTSPVPAVTFTTPL 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/58 (31%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	60/296 (20%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	21/106 (20%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		leucine-rich repeat	279..302	CDD:275380	9/46 (20%)
		LRR_8	303..361	CDD:290566	14/116 (12%)
		leucine-rich repeat	303..326	CDD:275380	5/72 (7%)
		leucine-rich repeat	327..350	CDD:275380	4/23 (17%)
		LRR_8	349..407	CDD:290566	20/94 (21%)
		LRR_4	350..390	CDD:289563	14/76 (18%)
		leucine-rich repeat	351..374	CDD:275380	7/52 (13%)
		leucine-rich repeat	375..398	CDD:275380	7/29 (24%)
		LRR_8	398..>443	CDD:290566	15/44 (34%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	10/23 (43%)
		LRRCT	503..554	CDD:214507	15/53 (28%)
slitrk4	XP_004916941.2	internalin_A	<30..>268	CDD:380193	55/240 (23%)
		leucine-rich repeat	78..99	CDD:275380	5/20 (25%)
		LRR_8	102..158	CDD:404697	17/55 (31%)
		leucine-rich repeat	102..123	CDD:275380	6/20 (30%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR_8	147..205	CDD:404697	20/58 (34%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..194	CDD:275380	9/21 (43%)
		leucine-rich repeat	195..219	CDD:275380	6/23 (26%)
		leucine-rich repeat	220..312	CDD:275380	7/91 (8%)
		leucine-rich repeat	313..416	CDD:275380	22/112 (20%)
		leucine-rich repeat	372..392	CDD:275380	3/19 (16%)
		PPP1R42	373..546	CDD:411060	48/173 (28%)
		LRR_8	416..473	CDD:404697	17/56 (30%)
		leucine-rich repeat	417..440	CDD:275380	8/22 (36%)
		leucine-rich repeat	441..464	CDD:275380	9/22 (41%)
		leucine-rich repeat	465..486	CDD:275380	0/20 (0%)
		leucine-rich repeat	489..510	CDD:275380	9/20 (45%)
		leucine-rich repeat	512..536	CDD:275380	10/23 (43%)
		TPKR_C2	545..>577	CDD:417692	11/35 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910