DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and slitrk2

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_004916940.1	Gene:	slitrk2 / 100497153	XenbaseID:	XB-GENE-964776	Length:	846	Species:	Xenopus tropicalis

Alignment Length:	608	Identity:	142/608 - (23%)
Similarity:	220/608 - (36%)	Gaps:	178/608 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 VWHLATGS-----QIEWNHCTSGVC--RC-----------NPDTKSFTC---------------W 166
            :|.|:..|     :.|.......:|  ||           |.:.|.||.               .
Frog     5 IWLLSVISLTGILKTESRKTAKDICKIRCVCEEKENVLNINCENKGFTSVSLLLPPQSRIYQLFL 69

  Fly   167 NTNLKS--VPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLD 229
            |.||.|  .|...|...|.|.:.|..|.|..:....|.||..||.|.:::|.|:.|..:.||.|:
Frog    70 NGNLLSRLYPNEFVNYSNAVTLHLGNNELQEIKTGAFNGLKTLKRLHLNNNKLEVLREETFQGLE 134

  Fly   230 SLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFP- 293
            ||..|:...|.:..|:...|.||..|.:|.|:.|.:..||.::|... .||.:::..|:::..|
Frog   135 SLEYLQADYNFISIIEAGAFSKLNKLKVLILNDNLLLSLPNNVFRFV-LLTHLDLRGNRLKMLPF 198

  Fly   294 PNLLRD-----QLMLEE---------------LDMSRNKISE--------LSSGSIRYLTKLKTL 330
            ..:|..     ::.|||               ||.....:.|        |....:..||:....
Frog   199 AGVLEHIGGIMEIQLEENPWNCTCDLIPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDLC 263

  Fly   331 D------------FGWNQIAKIDDDFFAGL---------RSLRTLSLHNNRI------------- 361
            .            |...:|.:|...|...:         |..:|.:....|:
Frog   264 PRKSSSDTNQRPAFSDPRIHRIPPTFNPAIIPTRVPKASRPPKTRNRPTPRVTVSKDRQIFGPIM 328

  Fly   362 ---------------------SSLSGTIFN-------NLANLV-------TLDLTTNRISHIDGN 391
                                 :|.||...|       |:::|.       .|.||.|.:..:...
Frog   329 VYQTKSPVPLTCPESCVCTSQNSDSGLNINCQERKISNISDLQPKPTHPRKLYLTGNYLQTVYKA 393

  Fly   392 AFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNNNI 456
            ..:|..:|:.|.||.|.::.|....|.|:::|.||.|..|.|..|....|.||.:|:.|.|..|:
Frog   394 DLLEFGSLDLLHLGNNRIAMIQEGAFSNLTSLRRLYLNGNYLEILYPSIFDGLYSLQYLYLEYNV 458

  Fly   457 LKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHG-------LKN-----------------LVA 497
            :|:...|.|:.||.|:.|.:::|.|..||.....|       |:|                 .:.
Frog   459 IKDILPRTFDALSNLQLLFLNNNLLRSLPENVFEGTALTRLNLRNNHFSSLPAKGVLDQLTVFIQ 523

  Fly   498 VKLDKNPWHCDCRALYLARWIRE----FVLKLWDGQQPMCRGPGDLGGHEVGLLRYDDLC----D 554
            :.|.:|||.|:|..|.|..||.:    .|:     |:..|..|....|..:.||..|.:|    :
Frog   524 IDLQENPWDCNCDILGLKNWIEQSSSTVVV-----QEVTCDSPLKHAGEHLRLLSKDVICPDYPN 583

  Fly   555 GQWASMLSLSPRLPVRKHQISTP 577
            ...|::||.:       |:..||
Frog   584 MSDATLLSYN-------HKSFTP 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	21/58 (36%)
		leucine-rich repeat	187..206	CDD:275380	6/18 (33%)
		LRR_RI	<201..386	CDD:238064	58/282 (21%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	17/80 (21%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		leucine-rich repeat	279..302	CDD:275380	5/28 (18%)
		LRR_8	303..361	CDD:290566	15/101 (15%)
		leucine-rich repeat	303..326	CDD:275380	8/45 (18%)
		leucine-rich repeat	327..350	CDD:275380	4/43 (9%)
		LRR_8	349..407	CDD:290566	18/105 (17%)
		LRR_4	350..390	CDD:289563	12/87 (14%)
		leucine-rich repeat	351..374	CDD:275380	7/63 (11%)
		leucine-rich repeat	375..398	CDD:275380	6/29 (21%)
		LRR_8	398..>443	CDD:290566	16/44 (36%)
		leucine-rich repeat	399..422	CDD:275380	8/22 (36%)
		leucine-rich repeat	423..443	CDD:275380	8/19 (42%)
		leucine-rich repeat	471..494	CDD:275380	8/29 (28%)
		LRRCT	503..554	CDD:214507	18/58 (31%)
slitrk2	XP_004916940.1	LRR	<44..>197	CDD:227223	45/153 (29%)
		leucine-rich repeat	66..87	CDD:275380	6/20 (30%)
		leucine-rich repeat	90..111	CDD:275380	6/20 (30%)
		LRR_8	111..170	CDD:338972	21/58 (36%)
		leucine-rich repeat	112..135	CDD:275380	9/22 (41%)
		leucine-rich repeat	136..159	CDD:275380	7/22 (32%)
		leucine-rich repeat	160..182	CDD:275380	7/22 (32%)
		leucine-rich repeat	183..207	CDD:275380	5/23 (22%)
		leucine-rich repeat	208..369	CDD:275380	21/160 (13%)
		TPKR_C2	216..>252	CDD:387596	4/35 (11%)
		leucine-rich repeat	370..400	CDD:275380	6/29 (21%)
		LRR_8	400..459	CDD:338972	22/58 (38%)
		leucine-rich repeat	401..424	CDD:275380	8/22 (36%)
		leucine-rich repeat	425..448	CDD:275380	10/22 (45%)
		leucine-rich repeat	449..468	CDD:275380	6/18 (33%)
		leucine-rich repeat	496..509	CDD:275378	2/12 (17%)
		leucine-rich repeat	521..533	CDD:275378	4/11 (36%)
		LRRCT	529..579	CDD:214507	17/54 (31%)
		Thioredoxin_like	728..>822	CDD:381987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910