DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lrrc15

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_031758235.1	Gene:	lrrc15 / 100496322	XenbaseID:	XB-GENE-990725	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	440	Identity:	117/440 - (26%)
Similarity:	187/440 - (42%)	Gaps:	60/440 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 WNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMN---------MVNID-------------- 187
            :..|.|. |.| |......|      |.|...|||.|         :||.:
Frog    20 YGQCPSD-CIC-PRPGQVDC------SGPEVLVIPDNIPQNIRTLQIVNTEVTELPNGILQNMTA 76

  Fly   188 -----LSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHR 247
                 :.:|.|||:....|..|..|:.|.:::|.|..|..:||:||..|..|.:.|||:..|...
Frog    77 LLILRIEKNELSTVGSTAFHNLISLRYLSLANNKLQELHGNLFKDLAKLETLILSNNQINQIHPS 141

  Fly   248 TFWKLRNLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNK 312
            .|..|.|:..|.:..|.:..:|...|.....|..:|:..|.|:..||........|:.|.:..|:
Frog   142 LFTALSNVKDLQMVGNNLESIPVGAFDQMSGLLKLNLAKNSIKYLPPQAFDKLAKLQTLRLYENQ 206

  Fly   313 ISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVT 377
            :.::.:|.::.|:.|:.:....|::.::..|.|:|...|:.:.|.||.|.||...||.||..:..
Frog   207 LQDIPAGFLKKLSSLQEVALHSNKLIELSTDTFSGNPYLQKVFLSNNEIDSLPRGIFLNLPEITK 271

  Fly   378 LDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQ 442
            |.|..|.:..:....|..:..|.||:|..|.:..:..::|.|::....|.:..|.:.::....|.
Frog   272 LTLYGNALRELTTGVFGPMPKLKELWLYDNQLEQLTDNVFSNLTETVLLVISKNKIRSISTHAFC 336

  Fly   443 GLNNLKILLLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFL----------------------- 484
            ||..|:.|.|:.|:|...|....:.|.:|:.:.:.|||:.:|
Frog   337 GLEELQELSLHTNLLTTLDQDVLKCLPKLQNISLHSNKIQYLPGDLFKNMDTVMNIQLQNNSLED 401

  Fly   485 -PHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMC 533
             ||.....|..|..|||.:|||.||...|.|..|:.|.:.||.:..|.:|
Frog   402 IPHDFFDSLVQLNEVKLYENPWKCDHNLLSLKNWLSENMNKLGNLSQLVC 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	22/86 (26%)
		leucine-rich repeat	187..206	CDD:275380	6/37 (16%)
		LRR_RI	<201..386	CDD:238064	54/184 (29%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	14/59 (24%)
		leucine-rich repeat	255..278	CDD:275380	4/22 (18%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	14/57 (25%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	19/57 (33%)
		LRR_4	350..390	CDD:289563	14/39 (36%)
		leucine-rich repeat	351..374	CDD:275380	11/22 (50%)
		leucine-rich repeat	375..398	CDD:275380	4/22 (18%)
		LRR_8	398..>443	CDD:290566	10/44 (23%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	3/19 (16%)
		leucine-rich repeat	471..494	CDD:275380	8/46 (17%)
		LRRCT	503..554	CDD:214507	13/31 (42%)
lrrc15	XP_031758235.1	leucine-rich repeat	35..51	CDD:275380	7/21 (33%)
		LRR_8	51..111	CDD:404697	11/59 (19%)
		leucine-rich repeat	54..76	CDD:275380	2/21 (10%)
		leucine-rich repeat	77..100	CDD:275380	6/22 (27%)
		internalin_A	98..>449	CDD:380193	96/350 (27%)
		leucine-rich repeat	101..124	CDD:275380	9/22 (41%)
		leucine-rich repeat	125..148	CDD:275380	8/22 (36%)
		leucine-rich repeat	149..172	CDD:275380	4/22 (18%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		leucine-rich repeat	197..220	CDD:275380	5/22 (23%)
		leucine-rich repeat	221..244	CDD:275380	5/22 (23%)
		leucine-rich repeat	245..268	CDD:275380	11/22 (50%)
		leucine-rich repeat	269..292	CDD:275380	4/22 (18%)
		leucine-rich repeat	293..316	CDD:275380	7/22 (32%)
		leucine-rich repeat	317..340	CDD:275380	5/22 (23%)
		leucine-rich repeat	341..362	CDD:275380	6/20 (30%)
		leucine-rich repeat	365..388	CDD:275380	5/22 (23%)
		leucine-rich repeat	389..410	CDD:275380	2/20 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D595054at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47585
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010