DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and LOC100495962

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_004912402.2	Gene:	LOC100495962 / 100495962	-ID:	-	Length:	1055	Species:	Xenopus tropicalis

Alignment Length:	618	Identity:	146/618 - (23%)
Similarity:	225/618 - (36%)	Gaps:	205/618 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 IVSQLLMLINSMPNGTQSAANDKKPPKSKANGHNDGDVNGGEINAMSHLANFDLVKRVRQ----- 123
            :|..:|:..||:.....:..|...|.|...||.:               .:||...|..|
Frog    23 LVLVVLITCNSLECSDTNPNNRTIPCKIAENGSS---------------VSFDCSARWLQMVPYP 72

  Fly   124 IESRLRSVEQPV---------------WHLATGSQIEWNH-----------CTSG---------- 152
            |:....|||..:               ||..|...:.|||           |..|
Frog    73 IKYSSDSVELLLSQNLILTINNESFHSWHNLTKIDLNWNHYPKSRLDNADICKRGLEIENGTFSY 137

  Fly   153 -------------VCRCN---PDTKSFTCWN-TNLKSVPVTQVIPM-NMVNIDLSRNI------- 192
                         :|:..   |.|.:|...: .|:.||....:.|: |:.|:.||.|.
Frog   138 LTKLEKLFIDHNYLCKIPQGIPSTLTFLSLSYNNIFSVKKQILSPLINLKNLFLSNNCYFGNECG 202

  Fly   193 -LSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLN 256
             :..:.:.||.|||.|.||.:|.|.|..:|..|   ..||..|.:.||.::.|:...|..|.||.
Frog   203 QVLDIEEGTFSGLTELTELSLSFNNLTHVPSKL---PASLKQLYLSNNNIQIINRNDFHNLVNLE 264

  Fly   257 ILDLS-------------KNEIGMLPES-------IFYHAQRLTVINMCDNQIQNFPPNLLRDQL 301
            :|.||             ||   :.|.:       .|.:.:.||.:::....::..||...::..
Frog   265 VLYLSGNCPRCFNANYPCKN---LCPNTSITIDHFAFQNLKNLTELHLSSTSLKTIPPTWFQNTT 326

  Fly   302 MLEELDMSRN-KISELSSGS-IRYLTKLKTLDFGWNQIAK-----ID-DDFFAGLRSLRTLSLHN 358
            .|::|.:.|| .::|::|.. :..|..|:.||..:|...:     |: .|.|:.|.||:  .||
Frog   327 QLKKLYLERNYLVNEIASADFLLNLPFLEVLDLSFNYDLRSYTNNINISDHFSKLVSLK--ELH- 388

  Fly   359 NRISSLSGTIF-----NNLANLVT------LDLTTNRISHIDGNAFVELNNLNELFLGQNSMS-- 410
                 :.|.:|     ||||.|:.      |:|.||.|..:|...|.:...|..::|.:|.::
Frog   389 -----IQGYVFKHIAANNLAPLLNLSKLKILNLGTNFIRQVDFKIFQQFTGLELIYLSENRITPF 448

  Fly   411 -------------------------SIPA-------------------------DLFLN------ 419
                                     |.|.                         ||.||
Frog   449 SEKNNKMKLVEGYEDKHSRVSSPGVSFPTQFNFQMTKTFSEVVKPQCSSRGKTLDLSLNSIFFID 513

  Fly   420 ------VSALTRLTLFSNNL-TTLEADDFQGLNNLKILLLNNNILKNFDA-RAFEPLSQLEKLRI 476
                  .|.::.|.|.||.: ..|...:|..|.||..|.|:.|.| :||: .||:.|..||.|.:
Frog   514 PKEFRSFSDVSCLNLSSNGIGQDLNGTEFIYLKNLTYLDLSFNKL-DFDSINAFQELPSLEVLDL 577

  Fly   477 DSNKLMFLPHGALHGLK---NLVAVKLDKNPWH 506
            ..|...|:..|.:|.||   ||..:|:....|:
Frog   578 SYNSHYFIVDGVIHSLKFIENLQHLKVLNLSWN 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	23/66 (35%)
		leucine-rich repeat	187..206	CDD:275380	7/26 (27%)
		LRR_RI	<201..386	CDD:238064	63/223 (28%)
		leucine-rich repeat	207..230	CDD:275380	8/22 (36%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	17/80 (21%)
		leucine-rich repeat	255..278	CDD:275380	8/42 (19%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	19/65 (29%)
		leucine-rich repeat	303..326	CDD:275380	7/24 (29%)
		leucine-rich repeat	327..350	CDD:275380	8/28 (29%)
		LRR_8	349..407	CDD:290566	20/68 (29%)
		LRR_4	350..390	CDD:289563	16/50 (32%)
		leucine-rich repeat	351..374	CDD:275380	8/27 (30%)
		leucine-rich repeat	375..398	CDD:275380	8/28 (29%)
		LRR_8	398..>443	CDD:290566	16/109 (15%)
		leucine-rich repeat	399..422	CDD:275380	9/86 (10%)
		leucine-rich repeat	423..443	CDD:275380	6/20 (30%)
		leucine-rich repeat	471..494	CDD:275380	9/25 (36%)
		LRRCT	503..554	CDD:214507	1/4 (25%)
LOC100495962	XP_004912402.2	LRR_8	81..151	CDD:404697	9/69 (13%)
		leucine-rich repeat	81..102	CDD:275380	2/20 (10%)
		leucine-rich repeat	103..140	CDD:275380	6/36 (17%)
		leucine-rich repeat	141..160	CDD:275380	1/18 (6%)
		PLN00113	153..>580	CDD:215061	110/441 (25%)
		leucine-rich repeat	162..185	CDD:275380	5/22 (23%)
		leucine-rich repeat	186..217	CDD:275380	8/30 (27%)
		leucine-rich repeat	218..262	CDD:275380	16/46 (35%)
		leucine-rich repeat	263..303	CDD:275380	8/42 (19%)
		leucine-rich repeat	304..327	CDD:275380	4/22 (18%)
		leucine-rich repeat	328..353	CDD:275380	7/24 (29%)
		leucine-rich repeat	354..383	CDD:275380	8/28 (29%)
		leucine-rich repeat	384..410	CDD:275380	10/33 (30%)
		leucine-rich repeat	411..434	CDD:275380	7/22 (32%)
		leucine-rich repeat	500..522	CDD:275380	4/21 (19%)
		leucine-rich repeat	526..547	CDD:275380	7/20 (35%)
		PPP1R42	545..788	CDD:411060	25/67 (37%)
		leucine-rich repeat	548..571	CDD:275380	10/23 (43%)
		leucine-rich repeat	572..601	CDD:275380	11/28 (39%)
		leucine-rich repeat	602..624	CDD:275380	2/9 (22%)
		leucine-rich repeat	625..655	CDD:275380
		leucine-rich repeat	656..679	CDD:275380
		leucine-rich repeat	680..703	CDD:275380
		leucine-rich repeat	704..727	CDD:275380
		leucine-rich repeat	728..751	CDD:275380
		leucine-rich repeat	752..770	CDD:275380
		TPKR_C2	786..>825	CDD:417692
		TIR_2	893..1030	CDD:419986
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910