DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7509 and tlr3

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_002934448.3	Gene:	tlr3 / 100486223	XenbaseID:	XB-GENE-491049	Length:	897	Species:	Xenopus tropicalis

Alignment Length:	543	Identity:	138/543 - (25%)
Similarity:	232/543 - (42%)	Gaps:	84/543 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LPLISSDTRNCSLNACESLGIVSQLLMLINSMPNGTQSAANDKKPPKSKANGHNDGDVNGGEIN- 107
            |.|.|:...|...|..|.|   ..||.|..|......:|..:|:    :.|...:..:|..:|:
Frog   126 LHLASNGISNIDGNPFEKL---ENLLFLDMSHNKMISTALGNKQ----QLNNLKELYLNSNKISK 183

  Fly   108 ----AMSHLANFDLVKRVRQIESRLRSVEQPVWHLATGS---------QIEWNHCTSGVCR--CN 157
                |...|||..|.|  ..:.|...:...|....|.||         |::... |..||.  .:
Frog   184 LNKEAFEFLANTSLQK--LDLSSNPLTEINPGCFQAIGSFAALVIQNTQLDPQR-TEQVCSELAH 245

  Fly   158 PDTKSFTCWNTNLKSVPVTQ---VIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDF 219
            ...::.|..|..|..:..|.   :...|:..:|||.|.||.:..|:|..|..|:.|::.:|.:..
Frog   246 TGVRNLTLNNIRLSKIRNTTFKGLADTNLTVLDLSGNSLSQIDNDSFVSLGALEILNLENNDISH 310

  Fly   220 LPFDLFQDLDSLLVLRIQ-----NNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQRL 279
            :....|..|..:.||.::     |.:|:|:   :|..|.|:..|::..|:|..:.|..|.....|
Frog   311 VNPKTFNGLSKVRVLNLRKSLSSNLKLDDL---SFQSLHNVQYLNMEANKIISITEHTFIGLTSL 372

  Fly   280 TVINMCDNQIQNFPPNLLRDQLMLE-------ELDMSRNKISELSSGSIRYLTKLKTLDFGWNQI 337
            |.:::.|:.:|.   :.|.::..|.       .|::::..::::.:|:...|..|:.||.|.|||
Frog   373 TNLSLSDSTLQQ---HTLTNRTFLSLSKSPLYHLNLTKTGLTKIENGAFLCLKHLQLLDMGLNQI 434

  Fly   338 -AKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGN--AFVELNNL 399
             .::..:...||.::..:.|..||..:|:...|....:|..|.|....::..|.|  .|..|.||
Frog   435 DQEVSGNELEGLANIEMIYLSYNRRITLTSNSFIFAPSLSKLYLRKTALTFRDLNPSPFKVLQNL 499

  Fly   400 NELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTL--EADD------FQGLNNLKILLLNNNI 456
            ..|.|..|::::|..|:|.::|.|..|:...|||..|  ||:.      .:||.||:.|.|.:|.
Frog   500 TVLDLSNNNIANIQEDVFESLSNLRILSFEHNNLARLWKEANPGGPVLFLKGLKNLEKLSLLSNG 564

  Fly   457 LKNFDARAFEPLSQLEKLRIDSNKLMFLPHGAL---HGL------KNLVA--------------- 497
            .....|.||:.|.:|:.|.|..|.:..||....   |.|      |||:.
Frog   565 FDEIPANAFKGLCKLKVLDIGENNVYILPPSVFDDQHSLTLLDLHKNLITSVEQDLFKNVFSSLK 629

  Fly   498 -VKLDKNPWHCDCRAL-YLARWI 518
             :.:..||:.|.|.:: :.|.|:
Frog   630 YLNMGGNPYDCTCESIAWFASWL 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	18/63 (29%)
		leucine-rich repeat	187..206	CDD:275380	9/18 (50%)
		LRR_RI	<201..386	CDD:238064	46/197 (23%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		leucine-rich repeat	231..254	CDD:275380	7/27 (26%)
		LRR_8	253..313	CDD:290566	13/66 (20%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	15/65 (23%)
		leucine-rich repeat	303..326	CDD:275380	4/29 (14%)
		leucine-rich repeat	327..350	CDD:275380	9/23 (39%)
		LRR_8	349..407	CDD:290566	16/59 (27%)
		LRR_4	350..390	CDD:289563	8/39 (21%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		leucine-rich repeat	375..398	CDD:275380	7/24 (29%)
		LRR_8	398..>443	CDD:290566	17/52 (33%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	8/27 (30%)
		leucine-rich repeat	471..494	CDD:275380	8/31 (26%)
		LRRCT	503..554	CDD:214507	6/17 (35%)
tlr3	XP_002934448.3	PLN00113	26..>507	CDD:215061	97/396 (24%)
		leucine-rich repeat	54..74	CDD:275380
		leucine-rich repeat	75..98	CDD:275380
		leucine-rich repeat	99..122	CDD:275380
		leucine-rich repeat	123..146	CDD:275380	7/22 (32%)
		leucine-rich repeat	147..170	CDD:275380	6/26 (23%)
		leucine-rich repeat	171..196	CDD:275380	6/24 (25%)
		leucine-rich repeat	197..230	CDD:275380	7/34 (21%)
		leucine-rich repeat	231..273	CDD:275380	7/42 (17%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		leucine-rich repeat	298..319	CDD:275380	4/20 (20%)
		leucine-rich repeat	322..347	CDD:275380	7/27 (26%)
		leucine-rich repeat	348..371	CDD:275380	5/22 (23%)
		leucine-rich repeat	424..448	CDD:275380	9/23 (39%)
		PPP1R42	446..637	CDD:411060	52/190 (27%)
		leucine-rich repeat	449..472	CDD:275380	5/22 (23%)
		leucine-rich repeat	473..498	CDD:275380	7/24 (29%)
		leucine-rich repeat	499..522	CDD:275380	7/22 (32%)
		leucine-rich repeat	523..554	CDD:275380	10/30 (33%)
		leucine-rich repeat	555..578	CDD:275380	8/22 (36%)
		leucine-rich repeat	579..602	CDD:275380	6/22 (27%)
		leucine-rich repeat	603..623	CDD:275380	4/19 (21%)
		PCC	607..>689	CDD:188093	9/46 (20%)
		Tlr3_TMD	691..720	CDD:407816
		TIR	746..890	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910