DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and tlr13

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_002935047.2	Gene:	tlr13 / 100485164	XenbaseID:	XB-GENE-5873547	Length:	948	Species:	Xenopus tropicalis

Alignment Length:	620	Identity:	144/620 - (23%)
Similarity:	239/620 - (38%)	Gaps:	192/620 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RNCSLNA-------CESLGIVSQLLMLINSMPNGTQSAANDKKPPKSKANGHNDGDVNGGEINAM 109
            |.|||..       |....:|: |...|..:|..|: ..|..:...||.:|:           ..
Frog    29 RKCSLEGIHTEYANCVGQSVVT-LADAIQDLPYQTR-VLNISENEISKIDGY-----------TF 80

  Fly   110 SHLANF-DLVKRVRQIESRLRSVEQPVWHLATG---SQIEWNHCTSGVCRCNPDTKSFTCWNTNL 170
            |||... :||.|    ::::..|:...:|....   ..:.:|...|      .||...    |:|
Frog    81 SHLPKLQELVLR----KNKVNGVDTWAFHNLNDLLILDLSYNLIQS------LDTVDL----TDL 131

  Fly   171 KSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGLTVLKELDIS-HNVLDF---------LP---- 221
            |.:.:          .|||.|.:.|:...|...|..|:|||:| :||.||         ||
Frog   132 KHLQI----------FDLSHNRIHTIQMGTLGPLGALQELDLSFNNVSDFRSVANAVSQLPDFLR 186

  Fly   222 --------FDLFQD-----LDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIF 273
                    .||..:     |.||..|.::||.:..:|. ||:.:.:|..|::::|.:..:.:|.|
Frog   187 LSLSSNFITDLKSEQSVTVLSSLQSLNLRNNSISVLDF-TFYSMPSLIELNVTRNNLSAVNKSSF 250

  Fly   274 YHAQRLTVINMCDNQIQNFP-------PNL-----------LRDQLM-----------LEELDMS 309
            .:...|..:...:|.: |..       |||           |:.:|:           |:.||:.
Frog   251 SNLPMLAKVTFDENSL-NISQLLGLVLPNLTEFHWSSMRPALQHELVSACQVFQTFPKLQLLDIK 314

  Fly   310 RNKISELSSGSIRYLTKLKTL----------------DFGWNQIAKID--------DDFFAGLRS 350
            .:||:..:...|...|.|.:|                ||.:.::..:|        :..:.||.:
Frog   315 HSKIAVTNLSIIGRCTNLTSLILSTSPLPRLQEKDLQDFKYLEVLYLDKCKLRRIANSSWRGLNN 379

  Fly   351 LRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFVEL------------------- 396
            |.||.|..|::|.|...:|:.|.:|..|||:.|.::|::..||..|
Frog   380 LHTLILERNQLSDLEDKLFSPLTSLQYLDLSKNYLTHLNEKAFSGLRRLNYLSLKGCKITAATRN 444

  Fly   397 -----NNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKIL-LLNNN 455
                 :||..|.|..||:|.|.::..:.:..|..|.|..|.:.|::.:..:||.:||.| |.|||
Frog   445 NFRYFSNLRVLDLQDNSISLIKSNAHIYLRKLETLLLSGNKILTIQKNGLKGLVSLKELSLANNN 509

  Fly   456 ILKNFDARAFEPLSQLEKLRIDSNKL------------------------------MFLPHGALH 490
            |.|..| ..|:.:..|..|.:..|:|                              :::|.....
Frog   510 IYKITD-NTFKFVKSLRSLDLSRNQLWPLHKFQSPTPFLNLTQLEYLDASYQAEGNIYIPASLFQ 573

  Fly   491 GLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKL 525
            ||::|..::|..||      :.:......||:|.|
Frog   574 GLQSLKVLRLQGNP------SAFFRNVSFEFLLNL 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	26/85 (31%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	64/264 (24%)
		leucine-rich repeat	207..230	CDD:275380	14/49 (29%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	16/88 (18%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		leucine-rich repeat	279..302	CDD:275380	7/40 (18%)
		LRR_8	303..361	CDD:290566	19/81 (23%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	7/46 (15%)
		LRR_8	349..407	CDD:290566	22/81 (27%)
		LRR_4	350..390	CDD:289563	15/39 (38%)
		leucine-rich repeat	351..374	CDD:275380	9/22 (41%)
		leucine-rich repeat	375..398	CDD:275380	9/46 (20%)
		LRR_8	398..>443	CDD:290566	13/44 (30%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	7/52 (13%)
		LRRCT	503..554	CDD:214507	6/23 (26%)
tlr13	XP_002935047.2	LRR_RI	<29..220	CDD:238064	55/227 (24%)
		leucine-rich repeat	62..85	CDD:275380	8/34 (24%)
		LRR_8	63..144	CDD:290566	23/116 (20%)
		leucine-rich repeat	86..133	CDD:275380	11/60 (18%)
		LRR_8	132..192	CDD:290566	19/69 (28%)
		leucine-rich repeat	134..157	CDD:275380	7/32 (22%)
		leucine-rich repeat	158..208	CDD:275380	14/49 (29%)
		LRR_8	186..242	CDD:290566	14/56 (25%)
		leucine-rich repeat	209..231	CDD:275380	7/22 (32%)
		leucine-rich repeat	232..307	CDD:275380	13/75 (17%)
		LRR_RI	253..534	CDD:238064	69/282 (24%)
		leucine-rich repeat	308..331	CDD:275380	6/22 (27%)
		leucine-rich repeat	332..355	CDD:275380	4/22 (18%)
		leucine-rich repeat	356..379	CDD:275380	3/22 (14%)
		LRR_8	379..438	CDD:290566	18/58 (31%)
		leucine-rich repeat	380..403	CDD:275380	9/22 (41%)
		leucine-rich repeat	404..427	CDD:275380	9/22 (41%)
		leucine-rich repeat	428..451	CDD:275380	0/22 (0%)
		leucine-rich repeat	452..475	CDD:275380	7/22 (32%)
		LRR_8	474..534	CDD:290566	21/60 (35%)
		leucine-rich repeat	476..499	CDD:275380	7/22 (32%)
		LRR_8	499..587	CDD:290566	20/88 (23%)
		leucine-rich repeat	500..523	CDD:275380	11/23 (48%)
		leucine-rich repeat	524..577	CDD:275380	7/52 (13%)
		leucine-rich repeat	578..631	CDD:275380	8/31 (26%)
		LRR_8	631..685	CDD:290566
		leucine-rich repeat	632..655	CDD:275380
		leucine-rich repeat	656..676	CDD:275380
		TIR	792..935	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910