DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lrrc4c

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	XP_002938986.1	Gene:	lrrc4c / 100188921	XenbaseID:	XB-GENE-5772259	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	470	Identity:	120/470 - (25%)
Similarity:	179/470 - (38%)	Gaps:	147/470 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 CTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILSTLHKDTFRGL-TVLKELDI 212
            |.| ||.|:.......|...||:.||                           .|: |..::|::
Frog    47 CPS-VCSCSNQFSKVICTRRNLREVP---------------------------DGISTNTRQLNL 83

  Fly   213 SHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNEIGMLPESIFYHAQ 277
            ..|.:..:..|.|:.|..|.||::..|.:..|:...|..|.|||.|:|..|
Frog    84 HENQIQIIKVDSFKHLRHLEVLQLSRNHIRTIEIGAFNGLANLNTLELFDN-------------- 134

  Fly   278 RLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKTLDFGWNQIAKIDD 342
            |||.|           ||                       |:..||:|||.|   |
Frog   135 RLTTI-----------PN-----------------------GAFEYLSKLKEL---W-------- 154

  Fly   343 DFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDL-TTNRISHIDGNAFVELNNLNELFLGQ 406
                         |.||.|.|:....||.:.:|..||| ...|:|:|...||..|:||..|.||.
Frog   155 -------------LRNNPIESIPSYAFNRIPSLRRLDLGEMKRLSYISEGAFEGLSNLKYLNLGM 206

  Fly   407 NSMSSIPADLFLNVSALTR---LTLFSNNLTTLEADDFQGLNNLKILLLNNNILKNFDARAFEPL 468
            .::..||     |::.|.:   |.|..|:|:.|....||||.:|:.|.:.::.::..:..||:.|
Frog   207 CNLRDIP-----NLTPLVKLDELDLSGNHLSVLRPGSFQGLTHLQKLWIMHSQIQVIERNAFDDL 266

  Fly   469 SQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQ--P 531
            ..|.:|.:..|.|..|||.....|.||..::|..|||:|:|..|:|:.|::|.|.   .|..  .
Frog   267 QSLVELNLAHNNLTLLPHDLFTPLHNLQRIQLHHNPWNCNCDILWLSWWLKEIVT---TGSTCCA 328

  Fly   532 MCRGPGDLGGHEVGLLRYD----------------DLCDGQWASMLSLSPRLPVRKHQISTPMNY 580
            .|..|..|.|..:..|.::                ::.:|..|.:          |.:.||.:.|
Frog   329 RCSTPPSLKGTHIAELDHNYFTCYAPVIVEPPADLNVTEGMAAEL----------KCRASTSLTY 383

  Fly   581 TDYFNLYLKHIYNGT 595
            ..:..      .|||
Frog   384 VSWIT------PNGT 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	11/59 (19%)
		leucine-rich repeat	187..206	CDD:275380	1/19 (5%)
		LRR_RI	<201..386	CDD:238064	46/186 (25%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	12/59 (20%)
		leucine-rich repeat	255..278	CDD:275380	5/22 (23%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	303..361	CDD:290566	11/57 (19%)
		leucine-rich repeat	303..326	CDD:275380	3/22 (14%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		LRR_8	349..407	CDD:290566	22/58 (38%)
		LRR_4	350..390	CDD:289563	14/40 (35%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	10/23 (43%)
		LRR_8	398..>443	CDD:290566	15/47 (32%)
		leucine-rich repeat	399..422	CDD:275380	7/22 (32%)
		leucine-rich repeat	423..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	471..494	CDD:275380	8/22 (36%)
		LRRCT	503..554	CDD:214507	16/68 (24%)
lrrc4c	XP_002938986.1	LRRNT	47..78	CDD:214470	12/58 (21%)
		LRR	<77..302	CDD:227223	83/301 (28%)
		leucine-rich repeat	78..101	CDD:275380	5/22 (23%)
		leucine-rich repeat	102..125	CDD:275380	7/22 (32%)
		leucine-rich repeat	126..149	CDD:275380	14/70 (20%)
		leucine-rich repeat	150..173	CDD:275380	11/46 (24%)
		leucine-rich repeat	174..198	CDD:275380	10/23 (43%)
		leucine-rich repeat	199..220	CDD:275380	8/25 (32%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	5/22 (23%)
		leucine-rich repeat	269..290	CDD:275380	7/20 (35%)
		LRRCT	301..351	CDD:214507	16/52 (31%)
		Ig	354..443	CDD:416386	9/55 (16%)
		Ig strand A	354..357	CDD:409353	0/2 (0%)
		Ig strand A'	361..364	CDD:409353	0/2 (0%)
		Ig strand B	370..377	CDD:409353	2/16 (13%)
		Ig strand C	383..388	CDD:409353	1/4 (25%)
		Ig strand C'	391..393	CDD:409353	2/2 (100%)
		Ig strand D	402..406	CDD:409353
		Ig strand E	409..413	CDD:409353
		Ig strand F	423..430	CDD:409353
		Ig strand G	433..443	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910