DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lrrn1-like

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001106456.1	Gene:	lrrn1-like / 100127637	XenbaseID:	XB-GENE-492890	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	491	Identity:	124/491 - (25%)
Similarity:	206/491 - (41%)	Gaps:	94/491 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 SRLRSVEQPVWHLATGSQIEWNH----CTSGVC--RCNPDTKSFTCWNTNLKSVPVTQVIPMNMV 184
            :|.:.::.|:| :.|...:...|    .|.|||  :|..:|:.   |.|           |.
Frog     7 ARSQRMKPPLW-METCLFVIVLHSVFFSTLGVCPPQCVCETRP---WFT-----------PQ--- 53

  Fly   185 NIDLSRNILSTLHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTF 249
                     |..|:        .|.:|.:..:|..:|.:|..|:.   ||.:|:|:   |.|.|
Frog    54 ---------SVYHE--------AKTVDCNDLLLTHIPENLSTDIQ---VLLLQSNK---ISHLT- 94

  Fly   250 WKLR---NLNILDLSKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRN 311
            |:|:   ||..||||:|....:.:....:..:|..:.:.:||::..|...|:|...||||.::.|
Frog    95 WELQELSNLTELDLSQNHFQSIDDLGVSNLSQLITLYLEENQLRELPDYSLKDLGSLEELYINHN 159

  Fly   312 KISELSSGSIRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLV 376
            :||.:...:...|.:|..|....|::..||..:|..|.:|..|.:..|.:::|....|..|..|.
Frog   160 QISYIGPRAFSGLGRLLRLHLNANRLEIIDPRWFEDLPNLEILMVGENPVTALQSLNFQPLGRLH 224

  Fly   377 TLDLTTNRISHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDF 441
            :|.|....:.||..|||..|:.|..|....|.::.:|.:...|:..|..|.|..|.:..:...||
Frog   225 SLVLAGMELEHIPENAFQGLDYLESLSFFDNRLTEVPKEALKNLKLLKFLDLNKNPIPEIRGGDF 289

  Fly   442 QGLNNLKILLLNN-NILKNFDARAFEPLSQLEKLR--------------------------IDSN 479
            .|:.:|:.|.||: ..|:..:|.||:.|.:|.||.                          :::|
Frog   290 TGMEHLEELSLNSMEELERVEAEAFQDLPELIKLEMCNNPRLSYLDPEAFSSNLGALKTLLLNNN 354

  Fly   480 KLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLARWIREFVLKLWDGQQPMCRGPGDLGGH-- 542
            :|..:|......|..|:.:.|..||..|||:..    |.....|:|.:.|..:|..|..:.||
Frog   355 RLAMVPLKIFQALPGLLEISLYSNPIRCDCQNC----WKGLSKLRLIEAQATLCINPPLVSGHLF 415

  Fly   543 -----EVGLLRYDDLCDGQWASMLSLSPRLPVRKHQ 573
                 :..|.|...|.|..     .:.|:..:.:||
Frog   416 QEIQGQAWLNRCPPLIDTH-----LIPPQFQIARHQ 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	12/58 (21%)
		leucine-rich repeat	187..206	CDD:275380	2/18 (11%)
		LRR_RI	<201..386	CDD:238064	52/187 (28%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	9/25 (36%)
		LRR_8	253..313	CDD:290566	18/62 (29%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	303..361	CDD:290566	18/57 (32%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR_8	349..407	CDD:290566	17/57 (30%)
		LRR_4	350..390	CDD:289563	11/39 (28%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	9/22 (41%)
		LRR_8	398..>443	CDD:290566	11/44 (25%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	7/48 (15%)
		LRRCT	503..554	CDD:214507	16/57 (28%)
lrrn1-like	NP_001106456.1	NEL	<52..>262	CDD:330839	64/236 (27%)
		leucine-rich repeat	60..79	CDD:275380	5/18 (28%)
		leucine-rich repeat	80..102	CDD:275380	9/28 (32%)
		LRR_8	101..161	CDD:316378	18/59 (31%)
		leucine-rich repeat	103..126	CDD:275380	6/22 (27%)
		leucine-rich repeat	127..150	CDD:275380	6/22 (27%)
		leucine-rich repeat	151..174	CDD:275380	8/22 (36%)
		leucine-rich repeat	175..198	CDD:275380	7/22 (32%)
		leucine-rich repeat	199..222	CDD:275380	6/22 (27%)
		leucine-rich repeat	223..246	CDD:275380	9/22 (41%)
		leucine-rich repeat	247..294	CDD:275380	12/46 (26%)
		LRR_8	294..356	CDD:316378	13/61 (21%)
		leucine-rich repeat	295..319	CDD:275380	9/23 (39%)
		leucine-rich repeat	320..345	CDD:275380	3/24 (13%)
		leucine-rich repeat	346..367	CDD:275380	3/20 (15%)
		PCC	351..>412	CDD:188093	17/64 (27%)
		leucine-rich repeat	370..382	CDD:275378	4/11 (36%)
		Ig	448..515	CDD:319273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910