DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lingo1

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001093719.1	Gene:	lingo1 / 100101739	XenbaseID:	XB-GENE-921957	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	416	Identity:	114/416 - (27%)
Similarity:	187/416 - (44%)	Gaps:	40/416 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 PVWHLATGSQIEWNHCTSGV---CRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRNILST 195
            |:..:..||.:..:  .||.   |.|:|..:|..|.......||  :.||.:...:|||:|.:..
Frog    11 PILLIVVGSILSGS--ASGCPQRCDCSPQDRSVLCHRKRYLDVP--EGIPTDTRLLDLSKNRIKA 71

  Fly   196 LHKDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDL 260
            |::|.|.....|:||:::.|::..:....|..|.:|..|.:::|:|:.|....|..|.||..||:
Frog    72 LNQDEFSAFPYLEELELNENIVSIIEPGAFNGLFNLRSLGLRSNRLKLIPLGVFTGLSNLTQLDI 136

  Fly   261 SKNEIGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLT 325
            |:|:|.:|.:.:|.....|..:.:.||.:........|....||||.:.:..::.:.:.::.:|.
Frog   137 SENKIVILLDDMFQDLYNLKSLEVGDNDLVYISHRAFRGLNSLEELTLEKCNLTSVPTEALSHLH 201

  Fly   326 KLKTLDFGWNQIAKIDDDFFAGLRSLRTLSL-HNNRISSLSGTIFNNLANLVTLDLTTNRISHID 389
            .|.||...:..|..|.|..|..|..|:.|.: |...:.:::......| ||.:|.:|.:.:|.|.
Frog   202 GLITLKLRYLNINVIRDYSFKRLYRLKNLEIAHWPYLDTMTSNGLYGL-NLTSLSITHSNLSSIP 265

  Fly   390 GNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKILLLNN 454
            ..|...|..|..|.|..|.::::...:...:..|....|....|:.:|...|:|||:||:
Frog   266 YVAIRHLVYLRFLNLSYNPITAVEGSMLYELLRLQEFHLVGGQLSVVEPYAFRGLNHLKV----- 325

  Fly   455 NILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYL--ARW 517
                               |.:.||.|..|...:.|.:.||..:.|||||..||||.|::  .||
Frog   326 -------------------LNVSSNYLSTLEESSFHSVGNLETLILDKNPLACDCRLLWIFRRRW 371

  Fly   518 IREFVLKLWDGQQPMCRGPGDLGGHE 543
            ...|     ..|||.|..|..:.|.|
Frog   372 RLNF-----SRQQPSCSSPEYVQGKE 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	16/58 (28%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	48/185 (26%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR_8	253..313	CDD:290566	17/59 (29%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	16/58 (28%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR_8	349..407	CDD:290566	15/58 (26%)
		LRR_4	350..390	CDD:289563	10/40 (25%)
		leucine-rich repeat	351..374	CDD:275380	4/23 (17%)
		leucine-rich repeat	375..398	CDD:275380	7/22 (32%)
		LRR_8	398..>443	CDD:290566	9/44 (20%)
		leucine-rich repeat	399..422	CDD:275380	4/22 (18%)
		leucine-rich repeat	423..443	CDD:275380	5/19 (26%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		LRRCT	503..554	CDD:214507	17/43 (40%)
lingo1	NP_001093719.1	LRRNT	27..61	CDD:214470	10/35 (29%)
		LRR 1	58..79		7/20 (35%)
		leucine-rich repeat	59..82	CDD:275380	7/22 (32%)
		PLN00113	62..>381	CDD:215061	95/348 (27%)
		LRR 2	82..103		5/20 (25%)
		leucine-rich repeat	83..106	CDD:275380	6/22 (27%)
		LRR_8	106..165	CDD:338972	19/58 (33%)
		LRR 3	106..127		6/20 (30%)
		leucine-rich repeat	107..130	CDD:275380	7/22 (32%)
		LRR 4	130..151		9/20 (45%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR 5	154..175		3/20 (15%)
		leucine-rich repeat	155..178	CDD:275380	4/22 (18%)
		LRR 6	178..199		4/20 (20%)
		leucine-rich repeat	179..250	CDD:275380	17/71 (24%)
		LRR 7	202..223		7/20 (35%)
		leucine-rich repeat	203..226	CDD:275380	8/22 (36%)
		LRR 8	250..271		7/20 (35%)
		leucine-rich repeat	251..274	CDD:275380	7/22 (32%)
		LRR 9	274..295		4/20 (20%)
		leucine-rich repeat	275..298	CDD:275380	4/22 (18%)
		LRR 10	298..319		5/20 (25%)
		leucine-rich repeat	299..322	CDD:275380	7/22 (32%)
		LRR 11	322..343		7/44 (16%)
		leucine-rich repeat	323..343	CDD:275380	7/43 (16%)
		Ig	425..500	CDD:386229
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910