DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7509 and lingo4a

DIOPT Version :9

Sequence 1:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001076447.1	Gene:	lingo4a / 100005227	ZFINID:	ZDB-GENE-060503-275	Length:	618	Species:	Danio rerio

Alignment Length:	450	Identity:	123/450 - (27%)
Similarity:	196/450 - (43%)	Gaps:	67/450 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 IEW--NHCTSGVCR----CNPDTKSFTCWNTNLKSVP-----VTQVIPMNMVNIDLSRNILSTLH 197
            ::|  ...|||.|.    |:|......|.:..|.:||     .|||       ::|:.|.|.||.
Zfish    30 LQWVVGVATSGPCAQRCDCSPKLPLVDCSSQQLSAVPEGVPDATQV-------LNLTYNHLKTLS 87

  Fly   198 KDTFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSK 262
            ...|..|..|:|||:|.|:|..:..:.|..|.:|:.||:..|:|:.|....|..|.|:..||:|:
Zfish    88 SRQFFSLRQLRELDLSANMLTVIEVEAFVGLQNLITLRLSRNRLKIIPVGAFSGLPNVQFLDISE 152

  Fly   263 NEIGMLPESIFYHAQRLTVINMCDNQI-----QNFP--PNLLRDQLMLEELDMSRNKISELSSGS 320
            |||.:|.:.:|.....|..:...:|.:     :.|.  ||||       ||.:.|..::.:.|.:
Zfish   153 NEILVLLDDMFGEMPSLQKLEASENDLVFISNRAFSGLPNLL-------ELRLERCNLTTVPSEA 210

  Fly   321 IRYLTKLKTLDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRI 385
            ...||.|:.|.|....:..:.::.|..|:.|:  .||.:|...|.....|:|..|
Zfish   211 FSRLTGLQHLRFCRLGLTALPNNSFRQLQRLQ--DLHVSRCPWLHTLAVNSLIGL---------- 263

  Fly   386 SHIDGNAFVELNNLNELFLGQNSMSSIPADLFLNVSALTRLTLFSNNLTTLEADDFQGLNNLKIL 450
                        ||..|.|...::|::|.....::..|..|.|..|.:||:.:.....|..|:.|
Zfish   264 ------------NLTSLTLSHCNLSAVPYAPLHHLVYLRYLDLSYNPITTVLSGLLGDLLRLQEL 316

  Fly   451 LLNNNILKNFDARAFEPLSQLEKLRIDSNKLMFLPHGALHGLKNLVAVKLDKNPWHCDCRALYLA 515
            .|.:..|.:.::.||..|:....|.:..|:|:.|...|.|.:.:|..::||.||..||||.|
Zfish   317 HLVSTGLLHVESGAFRNLAFFRLLNVSDNRLVTLEESAFHAVGSLEVLRLDGNPLACDCRLL--- 378

  Fly   516 RWIREFVLKL-WDGQQPMCRGPGDLGGHEVGLLRYDDLCDGQWASMLSL-SPRLPVRKHQ 573
             |:....|:| :.|..|.|..|..:.|.     .:.|..:.:.|...:. ..|:..||.|
Zfish   379 -WVMRRRLRLRFAGHAPSCVSPVQVQGR-----MFQDFAESEVARTFTCRQARILTRKPQ 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	20/58 (34%)
		leucine-rich repeat	187..206	CDD:275380	7/18 (39%)
		LRR_RI	<201..386	CDD:238064	54/191 (28%)
		leucine-rich repeat	207..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	231..254	CDD:275380	8/22 (36%)
		LRR_8	253..313	CDD:290566	19/66 (29%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		leucine-rich repeat	279..302	CDD:275380	7/29 (24%)
		LRR_8	303..361	CDD:290566	14/57 (25%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR_8	349..407	CDD:290566	12/57 (21%)
		LRR_4	350..390	CDD:289563	8/39 (21%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..398	CDD:275380	1/22 (5%)
		LRR_8	398..>443	CDD:290566	12/44 (27%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	423..443	CDD:275380	6/19 (32%)
		leucine-rich repeat	471..494	CDD:275380	6/22 (27%)
		LRRCT	503..554	CDD:214507	16/51 (31%)
lingo4a	NP_001076447.1	LRRNT	41..70	CDD:214470	7/28 (25%)
		leucine-rich repeat	52..72	CDD:275380	4/19 (21%)
		leucine-rich repeat	73..96	CDD:275380	10/29 (34%)
		LRR_RI	88..380	CDD:238064	90/326 (28%)
		LRR_8	95..155	CDD:290566	22/59 (37%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		leucine-rich repeat	145..168	CDD:275380	8/22 (36%)
		leucine-rich repeat	169..192	CDD:275380	3/22 (14%)
		LRR_8	191..250	CDD:290566	19/67 (28%)
		leucine-rich repeat	193..216	CDD:275380	7/29 (24%)
		leucine-rich repeat	217..240	CDD:275380	5/22 (23%)
		leucine-rich repeat	241..288	CDD:275380	14/70 (20%)
		LRR_8	264..323	CDD:290566	16/58 (28%)
		leucine-rich repeat	289..310	CDD:275380	6/20 (30%)
		LRR_8	312..371	CDD:290566	17/58 (29%)
		leucine-rich repeat	313..336	CDD:275380	7/22 (32%)
		leucine-rich repeat	337..356	CDD:275380	5/18 (28%)
		I-set	428..512	CDD:254352	2/4 (50%)
		Ig	439..512	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960