DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and ARHGEF1

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_945353.1	Gene:	ARHGEF1 / 9138	HGNCID:	681	Length:	927	Species:	Homo sapiens

Alignment Length:	833	Identity:	175/833 - (21%)
Similarity:	291/833 - (34%)	Gaps:	257/833 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1233 ETETVAELIENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRL 1297
            |.||.:|...:..|.|:|.:|      ...|      :.|.||.:.|:.:|..  :......|.|
Human    49 ELETNSEEQNSQFQSLEQVKR------RPAH------LMALLQHVALQFEPGP--LLCCLHADML 99

  Fly  1298 SNRGSISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPET---E 1359
            .:.|...:..:|.                   |.|.|         .||:.:|..:..|..   |
Human   100 GSLGPKEAKKAFL-------------------DFYHS---------FLEKTAVLRVPVPPNVAFE 136

  Fly  1360 LDAATRA---------KFYQLLVDATLAEI-------------------EHSTHMDQTLGTDSEH 1396
            || .|||         :|.|.:|.:....:                   :....::..:|.|...
Human   137 LD-RTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRAS 200

  Fly  1397 HYESIRHSGDPI---YEEI-HEVPPPLPLSAPPLNDAEL------------EKKAARSIF----- 1440
            :....||..:.:   .||: |.:......||..:|...|            :||:.|:.|
Human   201 YEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVM 265

  Fly  1441 ------EGASKYDILSYLVDAK--ERGLAREESFDYGNNPKIIEEEAADTLSDLDKRQAEERE-- 1495
                  |.|.....||.::||.  .||           .|::.:........|.:|..|.:|:
Human   266 GNRRSDEPAKTKKGLSSILDAARWNRG-----------EPQVPDFRHLKAEVDAEKPGATDRKGG 319

  Fly  1496 -----RDRD--------------------------------------SGQSSMSSLSPPPHNFIC 1517
                 |||:                                      .|..|:.||:||
Human   320 VGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPP------ 378

  Fly  1518 GGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRK 1582
              .....|::.|..:.|   :..:..||..:..|      |:..|..|        |..|.....
Human   379 --ESTDEGAETESPEPG---DEGEPGRSGLELEP------EEPPGWRE--------LVPPDTLHS 424

  Fly  1583 CGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTL 1647
            ..|.:|:|:|:|:|::.||..:.|.|:::.:.|..||........|:|..||.:.::|:|.:...
Human   425 LPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLF 489

  Fly  1648 AERMRDALDMSLEQGDDDLLTVNIGRIFL--------DFTQMLHAFESYCVRQAGASLLLANLE- 1703
            .:|:     |...| :...|...||.:.|        .:.|.:.:  .:|.||   |..|..|:
Human   490 LDRL-----MKRRQ-ESGYLIEEIGDVLLARFDGAEGSWFQKISS--RFCSRQ---SFALEQLKA 543

  Fly  1704 KEKELLRIFLKVSQMENAV-LRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQ 1767
            |:::..|....|.:.|:.. .||:.|...:...:||:|||||||..:.:.|....| ||.::.|.
Human   544 KQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-REKVELAA 607

  Fly  1768 EKIELHLNHINQEAKDVPTKL----WRRISSSSPNRRAS----CEIDMINIKLRKMAID-VLEWN 1823
            |.....|:|:||..:|:...|    ::|....|..|::|    .|...::|..:|:..: .|.|.
Human   608 ECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWR 672

  Fly  1824 HDEVR------FAMEGRLLYTQPTDSNW---KKARTIKLTPVNALLVTNGK---------PSANY 1870
            ..:.:      ..::..||..|..|...   ..:||:..||       :||         .||..
Human   673 VTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTP-------DGKTMLRPVLRLTSAMT 730

  Fly  1871 RAEKAMSEKLNFPKHTGIREASLLLVKEKCGRYTLIREPLYLDRCVVCSEADW 1923
            | |.|...|..:...|..:||.:         |.|:.:       .|....:|
Human   731 R-EVATDHKAFYVLFTWDQEAQI---------YELVAQ-------TVSERKNW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	53/195 (27%)
ARHGEF1	NP_945353.1	RGS_p115RhoGEF	67..259	CDD:188709	41/234 (18%)
		Trypan_PARP	<330..425	CDD:114603	17/119 (14%)
		RhoGEF	435..619	CDD:214619	53/195 (27%)
		PH_p115RhoGEF	653..777	CDD:275429	27/138 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810