Protein Alignment RhoGEF64C and ROM1

DIOPT Version :10

• Sequence 1: NP_729032.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: NP_011584.2
• Gene: ROM1 / 852961
• SGDID: S000003302
• Length: 1155
• Species: Saccharomyces cerevisiae
• Alignment Length: 1160
• Identity: 198/1160 - (17%)
• Similarity: 358/1160 - (30%)
• Gaps: 445/1160 - (38%)

  Fly   893 IKSNRSDSR-----DLFQRRPTEPPPPPPPKGAGKGLEPLPHEI--------------NKSPLSP 938
            :.||..|.|     ::|.::.......|....:|..::...:||              ||:.|..
Yeast     1 MNSNELDLRNKYFYEIFGKKRKSDTSTPTQLFSGSKVQTNINEISITNDEDEDSTEDENKASLKD 65

  Fly   939 QR------TVVRVAPFKPQQQQVGGSGDGFTHEVHRLKISHSEEDADLGVELRRRPNLFLSSPGE 997
            ..      ...|:||            |..:|::....:.|      :...|...|..|..
Yeast    66 YTLGHDTGARYRIAP------------DCSSHQLKASPVLH------ISTNLNSSPQSFTG---- 108

  Fly   998 EDAAP--KKTSILIS-----GDDCYSTMNLSANAAQPLYQSSVVVNSHSATSVCISVSSAEEQEQ 1055
            :..:|  ||.||..|     |:.|.:|.:.|...:..|...   |..||:.|:.....::.....
Yeast   109 DQISPTNKKISINDSTRQDKGNSCTTTSSPSQKRSNVLLPH---VRKHSSPSLLSFSKNSGSHMG 170

  Fly  1056 ELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSVSCISSTSSSSTSS-------------SSSSS 1107
            :.|||:|..:          |......:.|..|.:  ...|||||||             ||:||
Yeast   171 DPNQLSTPPT----------PKSAGHTMELHSSFN--GKHSSSSTSSLFALESLKTQNRRSSNSS 223

  Fly  1108 GRGRTLIRLDYDRERKGSATSSTPINTPPVISSTPATPPPTDLPIENANPLVPHETELLKILRNP 1172
            .......|.....:|..|.:.|:|::.             |::.:....|||  ...||.::
Yeast   224 NHSSQYRRHTNQHQRHHSRSKSSPVSL-------------TEISMIKGTPLV--YPALLSLI--- 270

  Fly  1173 VEAVKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETETV 1237
              |:|..                ::.|:...:..|.          |.:|...|:.|    .:|:
Yeast   271 --AIKFK----------------QTIKLSTHKKMGL----------LYRDSFTGKQA----IDTL 303

  Fly  1238 AELIENSLQRLQQARRGIDMSGTK-------DH---DDMNRLISASLQRIRLERQPATPGISATK 1292
            . ||..||.|......|..:...|       ||   |.:..:...|.:.|.:..|
Yeast   304 C-LIIGSLDRNLGMLIGKSLEAQKLFHDVLYDHGVRDSVLEIYELSSESIFMAHQ---------- 357

  Fly  1293 EEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPE 1357
                  ::.|.|.||:|:|:                                  ..||:.::
Yeast   358 ------SQSSTSIANTFSSS----------------------------------SSSVNSLR--- 379

  Fly  1358 TELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLS 1422
                  |:.:.|.:.|..|                   |.|.|
Yeast   380 ------TKTEIYGVFVPLT-------------------HCYSS---------------------- 397

  Fly  1423 APPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNNPKIIEEEAADTLSDLD 1487
                 ...|||               |.|.:..                |..::::|
Yeast   398 -----TCSLEK---------------LCYSISC----------------PNRLQQQA-------- 418

  Fly  1488 KRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPT 1552
                               :|    |..:.||..::....::::|....|.|:...:|.:::
Yeast   419 -------------------NL----HLKLGGGLKRNISLALDKEDDERISWTNSVPKSVWES--- 457

  Fly  1553 VLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCH 1617
                                          ..|::::|:|.|.|:..||:|:.:.|:||.:.|..
Yeast   458 ------------------------------LSKQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMK 492

  Fly  1618 PMLVAGLLTQEQ----LSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDF 1678
            .:|...::..:.    :..:|.:..::...|:...:.:.....:|       .:...|..|||.:
Yeast   493 KLLETNIIPSDVRINFVKHVFAHINEIYSVNREFLKALAQRQSLS-------PICPGIADIFLQY 550

  Fly  1679 TQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKV-SQMENAVLRRMNLNSFLMVPVQRVTKY 1742
            ......|.||...:..|..|   :|.::.:...|.:. .::.|:.||. .::|||...|.|..:|
Yeast   551 LPFFDPFLSYIASRPYAKYL---IETQRSVNPNFARFDDEVSNSSLRH-GIDSFLSQGVSRPGRY 611

  Fly  1743 PLLLARLYKVTPSHLEGRELL---KQAQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRRASCE 1804
            .||:             ||::   ....:|.:|.:   ..:.:|:...|.:||     :|.:...
Yeast   612 SLLV-------------REIIHFSDPVTDKDDLQM---LMKVQDLLKDLMKRI-----DRASGAA 655

  Fly  1805 IDMINIKLRKMAIDV------LEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTN 1863
            .|..::|:.|..|..      |..|:::.:...||.|
Yeast   656 QDRYDVKVLKQKILFKNEYVNLGLNNEKRKIKHEGLL---------------------------- 692

  Fly  1864 GKPSANYRAEKAMSEKLNFPKHTGIREASLLLVKEKC----GRYTLIREPLYLDRCVVCSEADWD 1924
            .:...| :.:.:.|..:.|    .:.:..||.:|.|.    .::|:.:.|:.|....:|...|..
Yeast   693 SRKDVN-KTDASFSGDIQF----YLLDNMLLFLKSKAVNKWHQHTVFQRPIPLPLLFICPAEDMP 752

  Fly  1925 D---YF-------------EVQEISSKDTFIFKAEDGVRTKQWYTQLQYHAQGMG 1963
            .   |.             :.|..:.|:..:| |..|  |||.|....|..|..|
Yeast   753 PIKRYVTENPNCSAGVLLPQYQTSNPKNAIVF-AYYG--TKQQYQVTLYAPQPAG 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_729032.1	RhoGEF	1590..1778	CDD:238091	41/195 (21%)
ROM1	NP_011584.2	ROM1	1..1155	CDD:227709	198/1160 (17%)