Protein Alignment RhoGEF64C and ROM2

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: NP_013475.1
• Gene: ROM2 / 851086
• SGDID: S000004363
• Length: 1356
• Species: Saccharomyces cerevisiae
• Alignment Length: 1208
• Identity: 218/1208 - (18%)
• Similarity: 380/1208 - (31%)
• Gaps: 396/1208 - (32%)

  Fly   768 DDDEHND--------KDESHDNK--------PNDLAEREQDREGDKE-------------QGRAG 803
            |.|.|.|        :.|:..|.        .||:...:|.|....|             :|::.
Yeast    33 DSDSHGDISSQLLPNRIENIQNLNVLLSEDIANDIIIAKQRRRSGVEAAIDDSDIPNNEMKGKSS 97

  Fly   804 ELGISRQEK----------KDAGGKPAASQKRAAQTTQSRNPIRRAHSERHLSTAPLAAHGHASS 858
            ...:|:|..          ..|...|.:|.|:|...|.| :||..|.|..|:       :..::|
Yeast    98 NYILSQQTNIKEVPDTQSLSSADNTPVSSPKKARDATSS-HPIVHAKSMSHI-------YSTSNS 154

  Fly   859 ACAAGRNCHSIPMTPPASGPQNVILNFKDTMALRIKSNRSDSRDLFQRRPTEPPPPPPPKGAGKG 923
            |....::.:..|: ||.| |:|.:          .:.|:|.:..:.:|:|:      .|:.|..|
Yeast   155 ASRQAKHYNDHPL-PPMS-PRNEV----------YQKNKSTTAFVPKRKPS------LPQLALAG 201

  Fly   924 LE-----------PLPHEINKSPLSPQRTVVRVAPFKPQQQQVGGSGDGF--------THEVHR- 968
            |:           ..|.:..||||                     .|.||        .||.|:
Yeast   202 LKKQSSFSTGSASTTPTQARKSPL---------------------QGFGFFSRPSSKDLHEQHQH 245

  Fly   969 -LKISHSEEDADLGVELRRRPNLFLSSPGEEDAAPKKTSILISGDDCYSTMNL-------SANAA 1025
             ..|.|:.                                 |:..:..:|.|.       |:|:.
Yeast   246 HQHIQHNN---------------------------------INNHNNNNTNNNGAHYQVGSSNSN 277

  Fly  1026 QPLYQSSVVVNSHSATSVCISVSSAEEQEQELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSVS 1090
            .|.:..|:...|.|..|..:...::..|.:..|.....:...:.......|.......:...|.|
Yeast   278 YPQHSHSISSRSMSLNSSTLKNIASSFQSKTSNSRKATQKYDITSNPFSDPHHHHHHHHSSNSHS 342

  Fly  1091 CIS----STSSSSTSSSSSSSGRG-RTLIRLDYDRERKGSATSSTPINTPPVISSTPATPPPTDL 1150
            .::    |.:|||...|||:.|.| :|.:.......::.::.|.|.:::|...|.||.:   ...
Yeast   343 SLNNVHGSGNSSSVMGSSSNIGLGLKTRVSSTSLALKRYTSVSGTSLSSPRRSSMTPLS---ASR 404

  Fly  1151 PIENANPLVP--HETELLKILRNPVEAVKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDP 1213
            |:.:|:...|  :...|.::......:::|                |:.||             .
Yeast   405 PVMSASSKKPQVYPALLSRVATKFKSSIQL----------------GEHKK-------------D 440

  Fly  1214 GFIAKLLQDPMLGQVAEGLETETVAELIENSLQRLQQA-RRGIDMSGTKDHDDMNRLISASLQRI 1277
            |.:   .:|...||.|    .:.:..:|..|.:.|... .|.:         |..:|....:...
Yeast   441 GLV---YRDAFTGQQA----VDVICAIIRTSDRNLALLFGRSL---------DAQKLFHDVVYEH 489

  Fly  1278 RLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSELTAS 1342
            ||...|..  :....:..|.:..||.::.:......|...|:     .||.|  |.:       |
Yeast   490 RLRDSPHE--VYEFTDNSRFTGTGSTNAHDPLMLLPNSSSFN-----SGNHS--YPN-------S 538

  Fly  1343 GILEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSE-HHYESIRHSGD 1406
            |::...|.|                               |.:.||...|.|. |...|:....:
Yeast   539 GMVPSSSTS-------------------------------SLNSDQATLTGSRLHMSSSLSQQKN 572

  Fly  1407 PIYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNN 1471
            |  ..||.|.....|.|              ..:......|.|.|.:..
Yeast   573 P--AAIHNVNGVFTLLA--------------ECYSPTCTRDALCYSISC---------------- 605

  Fly  1472 PKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVG 1536
            |:.:|::|                           .|:..|:    ||..::....::..|....
Yeast   606 PRRLEQQA---------------------------RLNLKPN----GGLKRNISMALDDDDEEKP 639

  Fly  1537 SETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETE 1601
            |.||..|:..::..|                                 ||.::|:|.|.|:..||
Yeast   640 SWTSSVSKEDWENLP---------------------------------KKEIKRQEAIYEVYITE 671

  Fly  1602 EKYGRDLQIILEEFCHPM----LVAGLLTQEQLSAIFLNTEDLLENN----QTLAERMRDALDMS 1658
            :.:.:.|:|..:.|...:    :::..:.:..:..:|.:..|:...|    :.|.:|.|.:   .
Yeast   672 KNFVKSLEITRDTFMKTLAETNIISADIRKNFIKHVFAHINDIYSVNRRFLKALTDRQRSS---P 733

  Fly  1659 LEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKV-SQMENAV 1722
            :.:|        ||.|.|.|......|.||...:..|..|   :|.::.:...|.:. ..|.::.
Yeast   734 VVRG--------IGDIVLRFIPFFEPFVSYVASRPYAKYL---IETQRSVNPYFARFDDDMMSSS 787

  Fly  1723 LRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVPTK 1787
            ||. .::|||...|.|..:|.||:..:.|.|....:     |...|.:        .:|.|....
Yeast   788 LRH-GIDSFLSQGVSRPGRYMLLVKEIMKSTDPEKD-----KSDYEDL--------SKAMDALRD 838

  Fly  1788 LWRRISSSSPNRRASCEIDMINIKLRKMAIDV------LEWNHDEVRFAMEGRLLYTQPTDSNWK 1846
            ..:||..:|     ....|..::||.|..|..      |..|.:..:...||.|...:.:.|:..
Yeast   839 FMKRIDQAS-----GAAQDRHDVKLLKQKILFKNEYVNLGLNDERRKIKHEGILSRKELSKSDGT 898

  Fly  1847 KARTIKLTPV-NALLVTNGKPSANYRAEKAMSEKLNFP 1883
            ....|:...: |.||....|....:...|.....:..|
Yeast   899 VVGDIQFYLLDNMLLFLKAKAVNKWHQHKVFQRPIPLP 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	41/194 (21%)
ROM2	NP_013475.1	ROM1	4..1356	CDD:227709	218/1208 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840