Protein Alignment RhoGEF64C and Arhgef11

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_006232821.1
• Gene: Arhgef11 / 78966
• RGDID: 619705
• Length: 1577
• Species: Rattus norvegicus
• Alignment Length: 1198
• Identity: 240/1198 - (20%)
• Similarity: 403/1198 - (33%)
• Gaps: 378/1198 - (31%)

  Fly   778 SHDNKPNDLAER-----------EQDREGDKEQG--RAGELGISRQEKKDAGGKPAASQKRAAQT 829
            ||..:|:|.:|.           ::|:.|   .|  .:|:..:..|..:..|....|..|...:.
  Rat    45 SHHRQPSDTSETTAGLVQRCVIIQKDQHG---FGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRI 106

  Fly   830 TQSRNPIRRAHSERHLSTAPLAAHGHASSACAAGRNCHSIPMTPPASGPQNVILNFKDTMALRIK 894
            .:....:  ..:..||....|...|..::....|       .:||:.|...:..|.......|:
  Rat   107 IKVNGTM--VTNSSHLEVVKLIKSGAYAALTLLG-------SSPPSVGVSGLQQNPSVAGVPRV- 161

  Fly   895 SNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLPHEINKSPLSPQRTVVRVAPFK-PQQQQVGGS 958
                        .|..|||||||                 ||.|.:.:....|.: |:.|:
  Rat   162 ------------NPIIPPPPPPP-----------------PLPPPQHITGPKPLQDPEVQK---- 193

  Fly   959 GDGFTHEVHRLKISHSEEDADLGVELRRRPNLFLSSPGEEDAAPKKTSILISGDDCYSTMNLSAN 1023
                 |....|:....:|:.:|
  Rat   194 -----HATQILRNMLRQEEKEL------------------------------------------- 210

  Fly  1024 AAQPLYQSSVVVNSHSATSVCISVSSAEEQ----EQELNQLNTLRSQQMGMGIAIIP-------- 1076
              |.:|:    |.|.:..|:      .|||    .:.:.||.....|:.|..:.|:|
  Rat   211 --QRIYE----VYSRNPASL------LEEQMEGARRRVTQLQLKIQQETGGLVDILPPCGETSQR 263

  Fly  1077 -IRGASEVNLQRSVSCISSTSSSSTSSSSSSSGRGRT---------------LIRLDYDRERKGS 1125
             ..|...|:.|.:.|.:.|.:....|.|.|...|...               |.|:.....|:||
  Rat   264 TCEGRLSVDSQEADSGLDSGTERFPSISESLMNRNSVLSDPGLDSPQTSPVILARVAQHHRRQGS 328

  Fly  1126 ATSSTPIN--------TPPVISSTPATPP-----PTDLPIENANPLVPHETELLKILR------- 1170
            ..:..|:|        .|.:|.......|     .:|:..::...|..|...|:..||
  Rat   329 DAALLPLNHQGIDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSHPAYLVVFLRYIFSQAD 393

  Fly  1171 -NPVEAVKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQD-------PMLGQ 1227
             .|       |:.::|                .|....|..||...:.|.:.:       |:..:
  Rat   394 PGP-------LLFYLC----------------SEVYQQTNPKDSRSLGKDIWNIFLEKNAPLRVK 435

  Fly  1228 VAEGLETE-------------TVAELIENSLQRLQQ------ARRGIDMSGTKDHDDMNRLISAS 1273
            :.|.|:.|             .:.|..|..:..:|:      ::|.:.:......:|:..|....
  Rat   436 IPEMLQAEIDLRLRNNEDPRNVLCEAQEAVMLEIQEQINDYRSKRTLGLGSLYGENDLLGLDGDP 500

  Fly  1274 L-QRIRLERQPATPG-ISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDCYQSCS 1336
            | :|...|:|.|..| |.:..||||       |:...||      :..|...||....:...||:
  Rat   501 LRERQMAEKQLAALGDILSKYEEDR-------SAPMDFA------VNTFMSHAGIRLRESRSSCT 552

  Fly  1337 SELTASGILEEDSVSPIKD------PETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSE 1395
            :|.|.|        :|.||      |:|:..::...|....|.|.....|
  Rat   553 AEKTQS--------APDKDKWLPFFPKTKKQSSNSKKEKDALEDKKRNPI--------------- 594

  Fly  1396 HHYESIRHSGDP---IYEEIHEVPPPLPLSAPPLNDAELEKKAARSI---FEGASKYDIL----- 1449
                 :|:.|.|   .....|          .||:..|::....|:|   ||.:.:||:.
  Rat   595 -----LRYIGKPKSSSQSTFH----------IPLSPVEVKPGNVRNIIQHFENSHQYDVPEPGTQ 644

  Fly  1450 -----SYLVDAKERG-------LAREESFDYGNNPKIIE--EEAADTLSDLDKRQAEERERDRDS 1500
                 |:..|..|..       |.|.||.......|...  |....:.||:|...|.|..|...|
  Rat   645 RLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEAARLHQS 709

  Fly  1501 GQSSMSSLS-------PPPHNFICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVL-HLC 1557
            ..||.||||       .||.      ..|.....:|..:.|.             .|..:| ||.
  Rat   710 ASSSASSLSTRSLENPTPPF------TPKMGRRSIESPNLGF-------------CTDVILPHLL 755

  Fly  1558 EDCDGAV-------EMQ-----VGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQI 1610
            ||..|.:       |:|     ||.:       |.....::.::|:|:|.|:..||..:.|.|::
  Rat   756 EDDLGQLSDLEPEPEVQNWQHTVGKD-------VVANLTQREIDRQEVINELFVTEASHLRTLRV 813

  Fly  1611 ILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERM----------RDALDMSLEQGDDD 1665
            :...|...|....|:.:|:|:.:|.|..:|:|.:.:..|.|          ||..|:.|.:.|
  Rat   814 LDLIFYQRMRKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIRDISDLMLARFD-- 876

  Fly  1666 LLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNS 1730
                  |....:..|:...|.||   |:.|..|:...::::...::|::.:: .:...||:.|..
  Rat   877 ------GPAREELQQVAAQFCSY---QSVALELIRTKQRKESRFQLFMQEAE-SHPQCRRLQLRD 931

  Fly  1731 FLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVPTK-----LWR 1790
            .::..:||:|||||||..:.|.|.......|.|.:|:::....|..:|:..|....:     ..:
  Rat   932 LIVSEMQRLTKYPLLLENIIKHTEGGTSEHEKLCRARDQCREILKFVNEAVKQTENRHRLEGYQK 996

  Fly  1791 RISSSSPNRRA---SCEIDMINIKLRKM 1815
            |:.:::..|.:   :.|...:::..|||
  Rat   997 RLDATALERASNPLAAEFKSLDLTTRKM 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	49/195 (25%)
Arhgef11	XP_006232821.1	PDZ_signaling	63..128	CDD:238492	11/69 (16%)
		DegQ	<78..154	CDD:223343	14/84 (17%)
		flgC	269..>358	CDD:139220	17/88 (19%)
		RGS_PDZRhoGEF	347..491	CDD:188707	24/166 (14%)
		RhoGEF	796..980	CDD:279015	49/195 (25%)
		PH_PRG	997..1139	CDD:275426	6/28 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810