DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and net1

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001072884.2	Gene:	net1 / 780346	XenbaseID:	XB-GENE-487220	Length:	585	Species:	Xenopus tropicalis

Alignment Length:	483	Identity:	105/483 - (21%)
Similarity:	202/483 - (41%)	Gaps:	100/483 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1410 EEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAK---ERGLAREESFDYGNN 1471
            ||:  :.||..|:.|..|..:.::|       |..:...:|.|...:   |.|.:|..|...|::
Frog     4 EEV--MAPPAALTPPSENVKDKKRK-------GVKRKSSVSSLAGGQSTPEGGSSRRYSLRRGSS 59

  Fly  1472 PKII----------------EEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGA 1520
            ...:                :::.|.:|...|.::...:.....|..:|:::|..|..|    ||
Frog    60 FTFLTPGSQWDFTLKRKRREKDDDALSLCSFDFKEPSTKRVRPLSRVTSLANLISPVRN----GA 120

  Fly  1521 GKSSGSDVE----RQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPL--- 1578
            .:..|..::    |.::.....|.|........||....               |.:|::.:
Frog   121 VRRFGQTIQSFTMRAENKSPGGTQKACSKVAAPTPPKRR---------------NSVLWSEMLDI 170

  Fly  1579 -VCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLE 1642
             :......|.::|:|.|.|:.:.|:....||::..:.:..|||...::::|:|:.||.:.:..:.
Frog   171 NMKESLSTKEIKRQEAIFEMTKGEQDLIDDLKLARKAYHDPMLKLSIMSEEELTQIFGDLDSYIP 235

  Fly  1643 NNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKE 1707
            .::.|..::.:|.......|       .||.|.:::...|:|::.||..|..|..|   |:|:|.
Frog   236 LHEELLAKLGEATKADGTVG-------QIGPILINWLPRLNAYKEYCSNQLAAKAL---LDKKKL 290

  Fly  1708 LLRI--FLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTP-SHLEGREL------- 1762
            ..|:  ||: ..:|:...|:::|.|||.:|..|:.||||||..:.:.|| .|.:.:.|
Frog   291 DRRVQDFLQ-RCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHTPKDHPDTKGLHEALCLI 354

  Fly  1763 --------LKQAQEKIELH---LNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMA 1816
                    ||:.:.:.:.:   |.:::.:.||:      ||.||   :...|..::.|....|:.
Frog   355 QGVLTDINLKKGESECQYYIDKLEYLDDKQKDL------RIESS---KALLCHGELKNKNGHKLF 410

  Fly  1817 I----DVLEWNHDEVRFAMEGRLLYTQP 1840
            :    |||......:|...:...:|.||
Frog   411 LFLFQDVLVLTRPVIRNEHQHFQVYRQP 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	52/206 (25%)
net1	NP_001072884.2	RhoGEF	186..362	CDD:366202	49/186 (26%)
net1	NP_001072884.2	PH_Net1	376..510	CDD:270044	17/72 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940