DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF64C and Akap13

DIOPT Version :9

Sequence 1:NP_001261425.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_036009413.1 Gene:Akap13 / 75547 MGIID:2676556 Length:2817 Species:Mus musculus


Alignment Length:2158 Identity:401/2158 - (18%)
Similarity:696/2158 - (32%) Gaps:749/2158 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 GGTGGTVRLPAVSGSSSSRRPMAATMRVVSATKKSRPSILDPQK--DPYDLMRRTRLLSPEPSS- 243
            |..|||     .|..||...|.||....|...::...||....|  .|.|      |..|.||| 
Mouse   572 GCEGGT-----TSDQSSPVLPAAAIENKVLGGQEPDTSIAGFCKTASPLD------LTMPGPSSD 625

  Fly   244 --KEADSKSRSR-SETVANQPRGRTRTRAPPPPAPIQKSPAVAVPT-----------AVPDPTD- 293
              .|.:|:|.:| :::::.|....:...|..|.|.....|:....:           ::|:.|. 
Mouse   626 GMPEQNSESHARPAQSLSGQALLCSTAEAGTPSAEATHQPSTVTSSGRLEECGSGKASLPESTMV 690

  Fly   294 -------CWLM--EDNESLLQSSGLASRANSRRSILRCHVNPYDLISSENG-------------- 335
                   |..:  ||.::...:|....  |:::|:..||:...|..:..||              
Mouse   691 QPSTQELCTTLCPEDPQADTVTSDTVK--NTQKSVGVCHLCVSDAKNQGNGLKQDTPLTNVLEDV 753

  Fly   336 -KLHS------------NLRKPNDHFDVA-----DAQLNDDELG---ERKSKGTSKFYSGNVAAI 379
             :|.|            .:..|...|.:|     ::...||.|.   .:|.|||:........|.
Mouse   754 PRLPSVVSQTEKELAPDQVSPPASSFSLASSPESESVTKDDALSLVPSQKEKGTATPQLHRTTAC 818

  Fly   380 A----GQRISLGDKSGD-SSDPGDSYERIIMVSGGESTASNGPRRPPRNKKADEPAEMPAAA--- 436
            .    |:.:|..||.|| ::||..|....:..|.|.::        |.....::....|.|.   
Mouse   819 RDGPDGRDLSDTDKVGDGATDPPPSSAVELRTSMGNTS--------PVGIGGEQEGSSPTATLEV 875

  Fly   437 -------GAAGAAGAAATSPPAAAVT-----AATAV----KPKAVTLAKVE------KIEKDNES 479
                   ....||..:..:.|...|:     ::||:    |.:|::.:.|:      ::.::::.
Mouse   876 LSDSLLHNVDKAALVSDFTLPEEGVSVVVPESSTALGQDGKDRAMSCSSVKEDVHSSEMSREDQR 940

  Fly   480 AYTVLTVTPTSPAIKSILKRPTTLELPGVGMSPLPLPPVNNSGLVTPAGKSQFYIPTPTGTAATP 544
                   ||           |:..|:||:...|:       |.|.......|.   ||:....|.
Mouse   941 -------TP-----------PSGQEIPGLCEKPM-------SALCAEEKAQQH---TPSACLKTE 977

  Fly   545 TSSSTPMATSTPTPNASITATTAAAGAAITPGSRKKVQFMVEDKIIATTATAATTDDSDAS---- 605
            |.....:|     |..|:.....||.:.:.|    :.....:.|     ..|::|:.|.:|    
Mouse   978 TKDIKEVA-----PQVSLLTEGGAAKSLVPP----RTSLSADSK-----QKASSTEQSGSSLLPS 1028

  Fly   606 ------------------AVATKTNYEYYNRKRNAATATAAAATAASAAAASPPTAATSTDQQEA 652
                              .|...|.::   .:.||...:.:|....:.|.|||.||  ...:::|
Mouse  1029 GLPGASEALHCNQPSALDVVVENTQFQ---GETNACEVSRSAMEDVTVADASPATA--EPRKKDA 1088

  Fly   653 TLFAADI------DDEHNFTTS-------------GEAAPPFIKPDSLHYEDVLPGPQIFDSSES 698
            :....||      :.|...|.|             .|...|.|:|.....| .|.|..:..::.:
Mouse  1089 SHCIKDIPISELLNQEKQMTPSLPEAFLDKGVTDLQEVITPEIEPLDCKRE-TLEGTDLNCATSN 1152

  Fly   699 SAKLSLPADGSPHVTTSPVSVLPTGTS---NGVGGAGLGP-GPAGVSGEEAPATAAATAAATQKT 759
            |.:..:.....|.....|..   ||.|   |.|..|.:.. ..|.:..||:.||..:|.||...|
Mouse  1153 SKETPIEKPMQPLARDLPTE---TGLSVINNNVPQADMKQVAQASIPAEESNATTVSTQAADVPT 1214

  Fly   760 TAANRDYDDDDEHNDKDESHDNKPNDLAEREQDREGDKEQGRAGELGISRQEKKDAGGKPAASQK 824
            .|               :|.:.....:.|                 .:.||.:        ||..
Mouse  1215 RA---------------DSIEETATRIVE-----------------AVIRQVR--------ASNA 1239

  Fly   825 RAAQTTQSRNPIRRAHSERHLSTAPLAAHGHASSACAAGRNCHSIPMTPPASGPQNVILNFKDTM 889
            ..|: .:::||...:...:.|..|      :..||||          ..|...||          
Mouse  1240 LMAK-VETQNPSLSSPETKQLENA------YTESACA----------FLPGETPQ---------- 1277

  Fly   890 ALRIKSNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLPHEINKSPLSPQRTVVRVAPFKPQQQQ 954
               |:....|:.........||.....|:.                          ||..|..: 
Mouse  1278 ---IEKTHEDTTGQCGAETEEPEKIILPES--------------------------APEMPDTR- 1312

  Fly   955 VGGSGDGFTHEVHRL-KIS-HSEEDADLGVELRRRPNLFLSSPGEEDAAPK-KTSILISGDDCYS 1016
               :||    ||..| :|| .|||:|                .|...|.|| |.......:||..
Mouse  1313 ---TGD----EVDLLSRISAASEEEA----------------VGNGAATPKMKQGPGTQANDCTR 1354

  Fly  1017 TMNLSANAAQPLYQSSVVVNSHS--ATSVCISVSS--AEEQEQELNQ-----LNTLRSQQMGMGI 1072
            .:...........:||..:|..|  |...|...:|  |.:|..|...     |.|..:.:.||  
Mouse  1355 VIPSCCEEKNQRNKSSPKINRESWCAIEPCPEAASLLASKQSSECRSFIDVGLGTECASKEGM-- 1417

  Fly  1073 AIIPIRGASEVNLQRSVS-----------------CISSTSSSSTSSSSSSSGRGRTLIRLDYDR 1120
             :..:.| ||.:|..|.|                 |.::.|||||..::|            .||
Mouse  1418 -LQRVSG-SESDLFHSPSDEMDSIIFPKPEEEQLLCDTTGSSSSTDDTAS------------LDR 1468

  Fly  1121 ERKGSATSSTPINTPPVISSTPATPPPTDLPIENANPLVPHETELLKILRNPVEAVKLNLVPHVC 1185
            .....:..|.|                              :|..|...||...|         .
Mouse  1469 HSSHGSDVSLP------------------------------QTSKLNRSRNHQSA---------N 1494

  Fly  1186 GLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETETVAEL------IENS 1244
            |..:|..|:.:|:: .|.|.:|:                 |::.|. |.:::.|:      :.:|
Mouse  1495 GFFSPGVEAPESRE-SESEPAGS-----------------GEMEEE-EMDSITEVPANCSFLRSS 1540

  Fly  1245 LQRLQQARR---GIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLSNRGSIS-- 1304
            ::.|...||   |...:...|.:...|....:|..: :.|.|.              :|.|:|  
Mouse  1541 MRSLSPFRRHSWGPGKNAASDAEMNQRSSMRALGHV-VRRPPI--------------HRRSMSWC 1590

  Fly  1305 -SANSFASAHN-------YELFDFDGGAGGNES----DCYQSCSSEL--TASGILEEDSVSPIKD 1355
             |...:::|.|       :.|....||..||:.    :...:.||||  ...|..:.:|:..:.:
Mouse  1591 PSGVQYSAALNADFNIRSFSLEGLTGGGVGNKPSSSLEMSSANSSELRNPFGGEEQRNSLMSLSE 1655

  Fly  1356 PETELDAATRAKFYQ----------------------LLVDATLAEIEHSTHMDQTLGTDSEHHY 1398
            ...|.|.....:.:.                      |....:|..|.|.       |.||...:
Mouse  1656 EHLEPDQRQHHRMFDQQTCYRSKQQGFNYCTSAISSPLTKSISLMTISHP-------GLDSSRPF 1713

  Fly  1399 ESI-RHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAR 1462
            .|. .:..:.|.||.....||.|      :....|:|:...:   :..:..:...:.:.::...:
Mouse  1714 HSTSANLTESITEENCNFLPPSP------SKKNFEEKSGTKV---SRTFSYIRNKMSSSKKSKEK 1769

  Fly  1463 EESFDYGNNPKIIEEEAADTLSDLDKRQAEERERDRDS------------GQSSMSSLSPPPHN- 1514
            |:..|     ||.|:|          :.::|:|:|:.:            |..|.|....|..| 
Mouse  1770 EKEKD-----KIKEKE----------KDSKEKEKDKKTLNGHTFSPIPIVGPISCSQCMKPFTNK 1819

  Fly  1515 --FICGGAG----------------------------------------KSSGSDVERQDS---- 1533
              :.|.|.|                                        ..|....||..|    
Mouse  1820 DAYTCAGCGAFVHKGCRENLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKSSQPKERPRSAVLL 1884

  Fly  1534 -------------------------------GVGSETSKTSRSKY--QATPTVLHLC---EDCDG 1562
                                           |||::.:.::..|:  .:|.::..:|   |..:.
Mouse  1885 ADEATAAPMFTNRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKICKVNESTES 1949

  Fly  1563 AVEMQVG--------------DNGILYAPLVCRKCGKK--------RVERKEIITEIVETEEKYG 1605
            ..:..||              |:..|.|....|....|        .|:|:|:|.|:::||..:.
Mouse  1950 LTDEGVGTDMNEGQLMGDFESDSKQLEAESWSRTVDSKFLKQQKKDVVKRQEVIYELMQTELHHI 2014

  Fly  1606 RDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENN----QTLAERMRDALDMSLEQGDDDL 1666
            |.|:|:.:.:...|:...|..|:.:..:|...::|:..:    |.:.||.:::|   :::.:.:.
Mouse  2015 RTLKIMSDVYSRGMMTDLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESL---VDKSEKNF 2076

  Fly  1667 LTVNIGRIFL-DFT-----QMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRR 1725
            |...||.:.: .|:     ::...:..:|.:...:.....:|..:.:..:.|:| .:|.::|:||
Mouse  2077 LIKRIGDVLVSQFSGESAERLKKTYGKFCGQHNQSVNYFKDLYTKDKRFQAFVK-KKMSSSVVRR 2140

  Fly  1726 MNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVPTKLWR 1790
            :.:...:::..||:||||:|..|:.:.|..                   |.:.||.......|.:
Mouse  2141 LGIPECILLVTQRITKYPVLFQRILQCTKD-------------------NEVEQEDLTQSLSLVK 2186

  Fly  1791 RISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTP 1855
            .:..:..::.||.|                    .:||...    :||: |||.           
Mouse  2187 DVIGAVDSKVASYE--------------------KKVRLGE----IYTK-TDSK----------- 2215

  Fly  1856 VNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASLLLVKEKCGRYTLIREPLYLDRCVVCSE 1920
                .:...|....:..|....:||       :|:.|:.| |...||...::..|..|..|...|
Mouse  2216 ----SIMRMKSGQMFAKEDLRRKKL-------VRDGSVFL-KSTTGRLKEVQAVLLTDILVFLQE 2268

  Fly  1921 ADWDDYFE---------------VQEISSKDTFIFKAEDGVRTKQWYTQLQYHAQGMGAWRKRRN 1970
            .|....|.               |:|::.::..:|....||:..:   .::.||..    |:.||
Mouse  2269 KDQKYVFASLDHKSTVISLKKLIVREVAHEEKGLFLISMGVKDPE---MVEVHASS----REERN 2326

  Fly  1971 ALANIM---INGM 1980
            :...|:   ||.:
Mouse  2327 SWIQIIQDTINSL 2339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_001261425.1 RhoGEF 1593..1779 CDD:279015 38/195 (19%)
Akap13XP_036009413.1 opacity_OapA <1150..>1298 CDD:411470 41/220 (19%)
C1_AKAP13 1792..1848 CDD:410428 8/55 (15%)
RhoGEF 1999..2193 CDD:238091 43/216 (20%)
PH_AKAP13 2236..2338 CDD:275427 25/116 (22%)
SMC_prok_B <2519..2674 CDD:274008
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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