Protein Alignment RhoGEF64C and Arhgef16

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: NP_001121063.1
• Gene: Arhgef16 / 687105
• RGDID: 1588981
• Length: 709
• Species: Rattus norvegicus
• Alignment Length: 585
• Identity: 125/585 - (21%)
• Similarity: 217/585 - (37%)
• Gaps: 157/585 - (26%)

  Fly  1336 SSELTASGILEEDSVSPIKDP------------ETELDAATRAKFYQLLVDATLAEIEHSTHMDQ 1388
            |.:..|:...|.|:...::.|            .|:..||.:....||        |..|..:..
  Rat    41 SLKARANAAFEPDAPESLQPPPPGDEEPRPIILSTQSPAALKMGTQQL--------IPKSLAVAS 97

  Fly  1389 TLGTDSEHHYESIRHSGDPIY--EEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSY 1451
            ...|.|...::|.   |..:.  |.....|..||..:..|:|.:::     ::..|..|.::.:.
  Rat    98 KAKTKSPARHQSF---GAAVLSKEAARRTPQLLPAPSFSLDDMDMD-----AVTGGNLKRNLRNQ 154

  Fly  1452 LVDAKERGL----AREESFDYGNNPKIIEEEAAD-------------------TLSDLDKRQAEE 1493
            ...|..:||    ::|:|...|...:.:.||||.                   :..|..:...|.
  Rat   155 SYRAAMKGLGPPSSKEDSVRLGPKLQALAEEAAQPPARHPAKNKKTWKRANKGSFKDDPQLYQEI 219

  Fly  1494 RERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCE 1558
            |||..::...|...:...|          ||....:|.|:.:..:|.:.::..:...|.||
  Rat   220 RERGLNTSHESDDDILDEP----------SSSGGTQRGDTTIVVKTYRPAQLTWSQLPEVL---- 270

  Fly  1559 DCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAG 1623
                       ::|||....|      :..:|:|.|.||:.:|..|...|:|::.||.....:..
  Rat   271 -----------ESGILDTLSV------EERKRQEAIFEILTSEFSYLHSLKILVNEFLQSQELKT 318

  Fly  1624 LLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTV-NIGRIFLDFTQ-MLHAFE 1686
            .:||.:...:|.|..|:|..:|...|        ||||.....:.| :|..|..|..: ..|.:.
  Rat   319 TMTQTEHHHLFSNISDVLAASQKFFE--------SLEQRHKAQVCVEDISDILEDHAENHFHPYI 375

  Fly  1687 SYCVRQAGASLLLANLEKE----KELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLA 1747
            :||..:......|..|...    :|:||...|:.....     :.:.|||::|:||||:.|||..
  Rat   376 AYCSNEVYQQRTLQKLSNSNTAFREVLREIEKLPACGG-----LPMISFLILPMQRVTRLPLLTD 435

  Fly  1748 RLYKVTPSHLEG-----------RELLKQAQE---KIE-------LHLNHINQEAKDVP------ 1785
            .|...|..|.|.           .:|:||..|   |:|       ||:.....:.|.:|
  Rat   436 TLCLKTQGHPERYKAASRALKAISKLVKQCNEGAHKMERTEQMYTLHMQLDFGKVKSLPLISASR 500

  Fly  1786 -------------TKLWRRISSSSPNRRASCEI----DMINIKLRK-----MAIDVLEWNHDEVR 1828
                         :.::|:|:|     |.:|.:    |::.:..:|     :..|..:.:|.:||
  Rat   501 WLLKRGELLLLEESSIFRKIAS-----RPTCYLFLFNDVLVVTKKKSEESYLVQDYAQLDHVQVR 560

  Fly  1829  1828
              Rat   561  560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	57/212 (27%)
Arhgef16	NP_001121063.1	RhoGEF	288..466	CDD:395496	52/190 (27%)
		PH_ephexin	489..622	CDD:269929	13/77 (17%)
		SH3_ARHGEF16_26	633..684	CDD:212871

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810