Sequence 1: | NP_001261425.1 | Gene: | RhoGEF64C / 38578 | FlyBaseID: | FBgn0035574 | Length: | 1984 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_003015.2 | Gene: | ITSN1 / 6453 | HGNCID: | 6183 | Length: | 1721 | Species: | Homo sapiens |
Alignment Length: | 1804 | Identity: | 324/1804 - (17%) |
---|---|---|---|
Similarity: | 552/1804 - (30%) | Gaps: | 601/1804 - (33%) |
- Green bases have known domain annotations that are detailed below.
Fly 495 SILKRPTTLELPGVGMSPLPLPPVNNSGLVTPAGKSQFYIPTPTGTAATPT------SSSTPMAT 553
Fly 554 STPTPNASI-------TATTAAAGAAITP---GSRKKVQFMVEDKIIATTATAATTDDSDASAVA 608
Fly 609 TKTNYEYYNRKRNAATATAAAATAASAAAASPPTAATSTDQQEATLFAADIDDEHNFTTSGEAAP 673
Fly 674 PFIKPDSLHYEDVLPGPQI-----FDSSESSAKLS------------LPADGSPHVTTSPVSVLP 721
Fly 722 TGTSNGVGGAGLGPGPAGVSGEEAPATAAATAAATQKTTAANRDYDDDDEHNDK-------DESH 779
Fly 780 DNKPNDLAEREQDREG-----DKEQGRAGELGISRQEKKDAGGKPAASQKRAAQ----------- 828
Fly 829 -TTQSRNPIRRAHSERHLSTAPLAAHGHASSACAAGRNCHSIPMTPPASGPQNVILNFKDTMALR 892
Fly 893 IKSNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLPHEIN--KSPLSPQRTVVRVAPFKPQQQQV 955
Fly 956 GGSGDGFTHEVHRLKISHSEEDADLGVELRRRPNLFLSSPGEEDAAPKKTSILISGDDCYSTMNL 1020
Fly 1021 SANAAQPLYQSSVVVNSHSATSVCISVSSAEEQEQEL---------------NQLNTLRSQQMGM 1070
Fly 1071 GIAIIPIRGASEVNLQRSVSCISSTSSSSTSSSSSSSGRGRTLIRLD------------------ 1117
Fly 1118 -----------------------------YDRERKGSATSSTPINTPPVISSTPATPPPTDLPIE 1153
Fly 1154 NA--NPLVPHETELLKIL----RNPVEAVKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKD 1212
Fly 1213 PGFIAKLLQDPMLGQVAEGLETETVAELI-ENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQR 1276
Fly 1277 IRLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDC-------YQS 1334
Fly 1335 CSSELTASGILEEDSVSPIKDPETELDAAT-------RAK------------------------- 1367
Fly 1368 --------FYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAP 1424
Fly 1425 PLNDAELEKKAARSIFEGASKYDILSYLVDAKERG----------LAREESFDY----------- 1468
Fly 1469 -----------------------GNNPKIIEEEAADTLSDLD----------------------- 1487
Fly 1488 KRQAEERERD-----------RDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVGSETSK 1541
Fly 1542 TSRSKYQATPTVLHLC--EDCD---GAVEMQVGDNGILYAPLVC------RKCGKKRV------- 1588
Fly 1589 ERKE--IITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERM 1651
Fly 1652 RDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVS 1716
Fly 1717 QMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEA 1781
Fly 1782 KDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEG---RLLYTQPTD- 1842
Fly 1843 ---------SNWKKARTIK-----LTPVNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASL 1893
Fly 1894 LLVKEKCGRYTLIREPLYLDRCVVCSEAD-----------------------------WDDYFEV 1929
Fly 1930 QEISSKDTFIFKAEDGVRTKQWYTQLQYHAQGMGAWRKRRNALANIMIN 1978 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
RhoGEF64C | NP_001261425.1 | RhoGEF | 1593..1779 | CDD:279015 | 56/185 (30%) |
ITSN1 | NP_003015.2 | EH | 14..108 | CDD:197477 | 13/43 (30%) |
EH | 26..90 | CDD:238009 | 3/10 (30%) | ||
EH | 214..309 | CDD:197477 | 16/96 (17%) | ||
EH | 225..291 | CDD:238009 | 10/67 (15%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 322..348 | 2/25 (8%) | |||
KLERQ | 326..702 | 69/459 (15%) | |||
GBP_C | <331..414 | CDD:303769 | 18/85 (21%) | ||
COG1340 | 372..686 | CDD:224259 | 58/397 (15%) | ||
coiled coil | 383..394 | CDD:293879 | 3/10 (30%) | ||
coiled coil | 403..414 | CDD:293879 | 2/10 (20%) | ||
AAA_23 | <509..636 | CDD:290211 | 22/170 (13%) | ||
GBP_C | <616..686 | CDD:303769 | 5/79 (6%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 650..701 | 4/50 (8%) | |||
SH3_Intersectin1_1 | 744..803 | CDD:212920 | 12/73 (16%) | ||
INTAP | 803..917 | CDD:293223 | 23/131 (18%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 836..868 | 4/31 (13%) | |||
SH3_Intersectin1_2 | 917..968 | CDD:212922 | 5/50 (10%) | ||
SH3_Intersectin1_3 | 1006..1057 | CDD:212924 | 6/50 (12%) | ||
SH3_Intersectin1_4 | 1074..1138 | CDD:212926 | 7/63 (11%) | ||
Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 | 1074..1138 | 7/63 (11%) | |||
Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 | 1104..1127 | 3/22 (14%) | |||
SH3_Intersectin1_5 | 1158..1211 | CDD:212928 | 12/52 (23%) | ||
RhoGEF | 1242..1422 | CDD:279015 | 56/184 (30%) | ||
PH_ITSN | 1448..1579 | CDD:270084 | 24/154 (16%) | ||
PH | 1465..1571 | CDD:278594 | 21/129 (16%) | ||
C2_Intersectin | 1582..1716 | CDD:176021 | 7/31 (23%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 1 | 1.000 | 87 | 1.000 | Domainoid score | I8015 |
eggNOG | 1 | 0.900 | - | - | E1_COG5422 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
3 | 2.810 |