DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF64C and ITSN1

DIOPT Version :9

Sequence 1:NP_001261425.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_003015.2 Gene:ITSN1 / 6453 HGNCID:6183 Length:1721 Species:Homo sapiens


Alignment Length:1804 Identity:324/1804 - (17%)
Similarity:552/1804 - (30%) Gaps:601/1804 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   495 SILKRPTTLELPGVGMSPLPLPPVNNSGLVTPAGKSQFYIPTPTGTAATPT------SSSTPMAT 553
            ||..:...|:|.|..: |..||||.         |.|     |...::.|.      :|..|:..
Human    79 SIAMKLIKLKLQGYQL-PSALPPVM---------KQQ-----PVAISSAPAFGMGGIASMPPLTA 128

  Fly   554 STPTPNASI-------TATTAAAGAAITP---GSRKKVQFMVEDKIIATTATAATTDDSDASAVA 608
            ..|.|..||       |..::...||:.|   |:...:|     .:.|....|||...|.:    
Human   129 VAPVPMGSIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQ-----PLPAFAHPAATLPKSSS---- 184

  Fly   609 TKTNYEYYNRKRNAATATAAAATAASAAAASPPTAATSTDQQEATLFAADIDDEHNFTTSGEAAP 673
                   ::|....:........|.|...||.|..|.....|.:.|....:.:.|:.|.||....
Human   185 -------FSRSGPGSQLNTKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTG 242

  Fly   674 PFIKPDSLHYEDVLPGPQI-----FDSSESSAKLS------------LPADGSPHVTTSPVSVLP 721
            |  :..::..:..||..|:     ....:...||:            :...|.|.....|...:|
Human   243 P--QARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIP 305

  Fly   722 TGTSNGVGGAGLGPGPAGVSGEEAPATAAATAAATQKTTAANRDYDDDDEHNDK-------DESH 779
            ........|:|:               :..::.:..:........:|:.:..:|       |:..
Human   306 PSFRRVRSGSGI---------------SVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTFEDKKR 355

  Fly   780 DNKPNDLAEREQDREG-----DKEQGRAGELGISRQEKKDAGGKPAASQKRAAQ----------- 828
            :|......|.|:.|:.     .|||.|..:|..:.||:|:   :....|:|..|           
Human   356 ENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKE---RERQEQERKRQLELEKQLEKQR 417

  Fly   829 -TTQSRNPIRRAHSERHLSTAPLAAHGHASSACAAGRNCHSIPMTPPASGPQNVILNFKDTMALR 892
             ..:.|...||...||..               ||.|...                     ...:
Human   418 ELERQREEERRKEIERRE---------------AAKRELE---------------------RQRQ 446

  Fly   893 IKSNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLPHEIN--KSPLSPQRTVVRVAPFKPQQQQV 955
            ::..|:..::|..:|..|.......|...|.||.....:|  |..|..:...:| .....|:|::
Human   447 LEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIR-CRLTTQRQEI 510

  Fly   956 GGSGDGFTHEVHRLKISHSEEDADLGVELRRRPNLFLSSPGEEDAAPKKTSILISGDDCYSTMNL 1020
            ..:..  :.|:...:|:|.::......::..|            ..|:|.   |..|........
Human   511 ESTNK--SRELRIAEITHLQQQLQESQQMLGR------------LIPEKQ---ILNDQLKQVQQN 558

  Fly  1021 SANAAQPLYQSSVVVNSHSATSVCISVSSAEEQEQEL---------------NQLNTLRSQQMGM 1070
            |      |::.|:|....:..:..::.....:|..|:               |||..||.     
Human   559 S------LHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELRE----- 612

  Fly  1071 GIAIIPIRGASEVNLQRSVSCISSTSSSSTSSSSSSSGRGRTLIRLD------------------ 1117
                  |....::..|:|:.          :.......:.|.:|.|:                  
Human   613 ------IHNKQQLQKQKSME----------AERLKQKEQERKIIELEKQKEEAQRRAQERDKQWL 661

  Fly  1118 -----------------------------YDRERKGSATSSTPINTPPVISSTPATPPPTDLPIE 1153
                                         .|.|.||...:...:.........|| .|....|..
Human   662 EHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPA-KPAVQAPWS 725

  Fly  1154 NA--NPLVPHETELLKIL----RNPVEAVKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKD 1212
            .|  .||.....|.:|::    ..|.|:...:.:         |.:.|....::.|.|..:...:
Human   726 TAEKGPLTISAQENVKVVYYRALYPFESRSHDEI---------TIQPGDIVMVKGEWVDESQTGE 781

  Fly  1213 PGFIAKLLQDPMLGQVAEGLETETVAELI-ENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQR 1276
            ||::...|:    |:.  |......||.| ||.:.           :..|...|..   ||...:
Human   782 PGWLGGELK----GKT--GWFPANYAEKIPENEVP-----------APVKPVTDST---SAPAPK 826

  Fly  1277 IRLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDC-------YQS 1334
            :.|...||...:::::.....:|....||....::....|..::|..|.......       .:|
Human   827 LALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRS 891

  Fly  1335 CSSELTASGILEEDSVSPIKDPETELDAAT-------RAK------------------------- 1367
            ..:..||:|    .|.||:.....:::...       |||                         
Human   892 AFTPATATG----SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFG 952

  Fly  1368 --------FYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAP 1424
                    |.:..|......|..||.||                ||.      .|.|..|...|.
Human   953 EVQGQKGWFPKSYVKLISGPIRKSTSMD----------------SGS------SESPASLKRVAS 995

  Fly  1425 PLNDAELEKKAARSIFEGASKYDILSYLVDAKERG----------LAREESFDY----------- 1468
            |         ||:.:..|  :..|..|..::.|:|          |..::..|:           
Human   996 P---------AAKPVVSG--EEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGDKAGV 1049

  Fly  1469 -----------------------GNNPKIIEEEAADTLSDLD----------------------- 1487
                                   |..|:|.:..|:.|.:..:                       
Human  1050 FPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEG 1114

  Fly  1488 KRQAEERERD-----------RDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVGSETSK 1541
            :.||..::|.           ...|.|.::...||          ||:......|..|:...|::
Human  1115 ELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPP----------KSTALAAVCQVIGMYDYTAQ 1169

  Fly  1542 TSRSKYQATPTVLHLC--EDCD---GAVEMQVGDNGILYAPLVC------RKCGKKRV------- 1588
            ...........::::.  ||.|   |.|..|||.....|..|..      :.|....:       
Human  1170 NDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPT 1234

  Fly  1589 ERKE--IITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERM 1651
            |||.  .|.|::.|||.|..|||::.|.|..|::.:.|||:::::.||:|.::|:..|..|.:.:
Human  1235 ERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKAL 1299

  Fly  1652 RDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVS 1716
            |....||.|:    :....||.|.......:..:..:|.||...:.|:.....|....:.|:|..
Human  1300 RVRKKMSGEK----MPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRL 1360

  Fly  1717 QMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEA 1781
            .|:.. .:.|.|:||::.|:||||:|||::..:.:.||.:......||.|.||.|...:.:|:..
Human  1361 AMDPR-CKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGV 1424

  Fly  1782 KDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEG---RLLYTQPTD- 1842
            ::                              |...|.|||....|:  .||   :|::...|: 
Human  1425 RE------------------------------KENSDRLEWIQAHVQ--CEGLSEQLVFNSVTNC 1457

  Fly  1843 ---------SNWKKARTIK-----LTPVNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASL 1893
                     ....||::.|     |.....||....||..:...:|..|.|.|.           
Human  1458 LGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNL----------- 1511

  Fly  1894 LLVKEKCGRYTLIREPLYLDRCVVCSEAD-----------------------------WDDYFEV 1929
                    :|.:.:.|::|:..:|....|                             |     |
Human  1512 --------QYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAW-----V 1563

  Fly  1930 QEISSKDTFIFKAEDGVRTKQWYTQLQYHAQGMGAWRKRRNALANIMIN 1978
            |:|.:......:.|...|.|.:..:.| .|.|:|          .:|:|
Human  1564 QKIKAASELYIETEKKKREKAYLVRSQ-RATGIG----------RLMVN 1601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_001261425.1 RhoGEF 1593..1779 CDD:279015 56/185 (30%)
ITSN1NP_003015.2 EH 14..108 CDD:197477 13/43 (30%)
EH 26..90 CDD:238009 3/10 (30%)
EH 214..309 CDD:197477 16/96 (17%)
EH 225..291 CDD:238009 10/67 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..348 2/25 (8%)
KLERQ 326..702 69/459 (15%)
GBP_C <331..414 CDD:303769 18/85 (21%)
COG1340 372..686 CDD:224259 58/397 (15%)
coiled coil 383..394 CDD:293879 3/10 (30%)
coiled coil 403..414 CDD:293879 2/10 (20%)
AAA_23 <509..636 CDD:290211 22/170 (13%)
GBP_C <616..686 CDD:303769 5/79 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..701 4/50 (8%)
SH3_Intersectin1_1 744..803 CDD:212920 12/73 (16%)
INTAP 803..917 CDD:293223 23/131 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..868 4/31 (13%)
SH3_Intersectin1_2 917..968 CDD:212922 5/50 (10%)
SH3_Intersectin1_3 1006..1057 CDD:212924 6/50 (12%)
SH3_Intersectin1_4 1074..1138 CDD:212926 7/63 (11%)
Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 1074..1138 7/63 (11%)
Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 1104..1127 3/22 (14%)
SH3_Intersectin1_5 1158..1211 CDD:212928 12/52 (23%)
RhoGEF 1242..1422 CDD:279015 56/184 (30%)
PH_ITSN 1448..1579 CDD:270084 24/154 (16%)
PH 1465..1571 CDD:278594 21/129 (16%)
C2_Intersectin 1582..1716 CDD:176021 7/31 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 87 1.000 Domainoid score I8015
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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