DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and ARHGEF28

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001073948.2	Gene:	ARHGEF28 / 64283	HGNCID:	30322	Length:	1731	Species:	Homo sapiens

Alignment Length:	1006	Identity:	199/1006 - (19%)
Similarity:	351/1006 - (34%)	Gaps:	237/1006 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   922 KGLEP--LPHEINKSPLSPQRTVVRVAPFKPQQQQVGGSGDGFTHEVHRLK---ISHSEEDADLG 981
            |..||  .|.|....|.|...|...:      :..|.........::.|:|   :.|:|.:....
Human   280 KAFEPEARPEERTAMPSSGAETEEEI------KNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHS 338

  Fly   982 VELRRRPNLFLSS--PGEEDAAPKKTSILISGDDCYSTMNLSANAAQPLYQSSVVVNSHSATSVC 1044
            ::|.|..::...|  |....||.:.:.:|..||:.|:.. :..:....|..|.:.:...:||
Human   339 LDLDRSFDILKKSKPPSTLLAAGRLSDMLNGGDEVYANC-MVIDQVGDLDISYINIEGITAT--- 399

  Fly  1045 ISVSSAEEQEQELNQLNTLRSQQMGMGIAIIP----IRGASEVNLQRSVSCISSTSSSSTSSSSS 1105
               :|.|.:...|...::..:.......::.|    :.|.:....|:|   ..|.|||..|:.:.
Human   400 ---TSPESRGCTLWPQSSKHTLPTETSPSVYPLSENVEGTAHTEAQQS---FMSPSSSCASNLNL 458

  Fly  1106 SSG-------------RGRTLIRLDYDRERKGSATSSTPINTPPVISSTPATPPPTDLPIENANP 1157
            |.|             |..:|..||.|.|.:|.       :.|..|..||.:...:...|.:.:.
Human   459 SFGWHGFEKEQSHLKKRSSSLDALDADSEGEGH-------SEPSHICYTPGSQSSSRTGIPSGDE 516

  Fly  1158 LVPHETEL---LKILRNPVEAVKLNLVPH---VCGLR-------APTRESGKSKKIQEEEVSGTP 1209
            |...||..   ..|.|.....:..||...   :.|:|       :|....||::.::|..|..:.
Human   517 LDSFETNTEPDFNISRAESLPLSSNLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSS 581

  Fly  1210 VKDPGFIAKLLQDPMLGQVAEGLETETVAELIENSLQRLQQARRGIDMSGTKDHDDMNRLISASL 1274
            .:...:  .|.:.|.                 ||.:|..:..:..|......:...::|..|..:
Human   582 EEQRAY--SLSEPPR-----------------ENRIQEEEWDKYIIPAKSESEKYKVSRTFSFLM 627

  Fly  1275 QRIRLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAG---------GNESD 1330
            .|:...|..:.......|::::| ||            |.:....|.|...         |.||.
Human   628 NRMTSPRNKSKTKSKDAKDKEKL-NR------------HQFAPGTFSGVLQCLVCDKTLLGKESL 679

  Fly  1331 CYQSCSSELTASGILEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQT-LGTDS 1394
            ...:|::.:.             |..:....|.|: ||.:          :::.:..|| ||..|
Human   680 QCSNCNANVH-------------KGCKDAAPACTK-KFQE----------KYNKNKPQTILGNSS 720

  Fly  1395 EHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERG 1459
                             ..::|.| .||..|.:...:.....|.  |...:...||..|.
Human   721 -----------------FRDIPQP-GLSLHPSSSVPVGLPTGRR--ETVGQVHPLSRSVP----- 760

  Fly  1460 LAREESFDYGNNPKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSS 1524
                     |...:.....|....|:.|......|... |....||.| ||...:||.
Human   761 ---------GTTLESFRRSATSLESESDHNSCRSRSHS-DELLQSMGS-SPSTESFIM------- 807

  Fly  1525 GSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVE 1589
             .||  .||.:.|:.|                    ..|.|.:.....::..|..|.:..|..::
Human   808 -EDV--VDSSLWSDLS--------------------SDAQEFEAESWSLVVDPSFCNRQEKDVIK 849

  Fly  1590 RKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDA 1654
            |:::|.|:::||..:.:.|.|:.|.|...|.....|....:..||...::|||.::.....|::.
Human   850 RQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKER 914

  Fly  1655 LDMSLEQGDDDLLTVNIGRIFL------DFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFL 1713
            ...|....|.:.:...||.|.:      :.::|...:..:|.....|..|...|::.|: .:.|:
Human   915 RQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKK-FQNFI 978

  Fly  1714 KVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRE-------LLKQAQEKIE 1771
            |: :..|.:.||..:...:::..||:||||:|:.|:.:.|....|..:       |:|.....::
Human   979 KL-RNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVD 1042

  Fly  1772 LHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIK----LRKMAIDVLEWNHDEVRFAME 1832
            |.:|...:..|      |..|.:...|:..:      .:|    .||.|:      ..|.|..:.
Human  1043 LKVNEYEKNQK------WLEILNKIENKTYT------KLKNGHVFRKQAL------MSEERTLLY 1089

  Fly  1833 GRLLYTQPTDSNWKKARTIKLTPVNALLVTN 1863
            ..|:|       ||.| |.:...:.|||:|:
Human  1090 DGLVY-------WKTA-TGRFKDILALLLTD 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	46/198 (23%)
ARHGEF28	NP_001073948.2	ANK	<153..216	CDD:295348
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..316		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..524		15/57 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..649		2/18 (11%)
		C1	653..698	CDD:237996	8/57 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..800		24/125 (19%)
		RhoGEF	853..1042	CDD:214619	44/190 (23%)
		PH_p190RhoGEF	1087..1187	CDD:275430	10/34 (29%)
		PH	<1123..1188	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1187..1207
		Interaction with PTK2/FAK1, required for regulation of axonal branching and synapse formation. /evidence=ECO:0000250	1295..1304
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1312..1339
		Mediates cytoplasmic retention and interaction with YWHAH. /evidence=ECO:0000250	1372..1383
		RNA-binding. /evidence=ECO:0000250	1496..1527
		Mediates cytoplasmic retention and interaction with MAPK8IP1. /evidence=ECO:0000250	1566..1579
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810