DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and arhgef3

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_005161924.1	Gene:	arhgef3 / 570228	ZFINID:	ZDB-GENE-050208-773	Length:	537	Species:	Danio rerio

Alignment Length:	550	Identity:	119/550 - (21%)
Similarity:	215/550 - (39%)	Gaps:	133/550 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1467 DYGNNPKIIEEEAADTLSDLDK-----RQAEERERDRD--------------------SGQSSMS 1506
            |..:.|.:..:|:...||..:|     ::.::|:||.|                    |..:|::
Zfish    18 DEASGPMVQGKESFSLLSTSEKWLFKGKKRKQRKRDVDSLSLCSLDINEPSTKRVKPLSRVTSLA 82

  Fly  1507 SLSPPPHNFICGGAGKSSGSDVERQ---DSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQV 1568
            ||.||    :.....|..|..::|.   .|....|.........|..||:   .:..|..:..:.
Zfish    83 SLIPP----VKAAPLKRIGQTLQRSISFRSDCRPEIMAPRPWSRQVVPTI---TKRRDSKLWSET 140

  Fly  1569 GDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAI 1633
            .|.|:.:      ....|.::|:|.|.|:.:.|:....||::..:.:..|||...::|:.:|:.|
Zfish   141 FDVGLGH------MLSSKEIKRQEAIFELSQGEQDLIEDLKLAKKAYHDPMLKLCIMTEHELNQI 199

  Fly  1634 FLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLL 1698
            |...:.|:..::.|..|:||.       .:.|..|.::|.|.:.:...|..:.|||..|..|..|
Zfish   200 FGTLDSLIPLHEDLLSRLRDV-------RNPDGSTDHMGHILVHWLPCLETYNSYCSNQVAAKAL 257

  Fly  1699 LANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELL 1763
            |.: :|:...:..||: ..:|:...|:::|.:||.:|..|:.||||||..:.|.||:....|:.|
Zfish   258 LDH-KKQDHRVHDFLQ-RCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILKHTPNEHPDRQHL 320

  Fly  1764 KQAQEKIELHLNHINQEAKDVPTKLWRR-------------ISSSSPNRRASCEIDMINIKLRKM 1815
            .:|...|:..:..||.:..:...:.::.             |.||   |...|..::.|.:..|:
Zfish   321 DEAINMIQSIVAGINTQTGESECRYYKERLLYLESGQRDLLIESS---RILICHGELKNNRGVKL 382

  Fly  1816 AI----DVL----EWNHDEVRFAMEGRLLYTQP---TDSNWKKARTIKLTPVNALLVTNGKPSAN 1869
            .:    |||    ..:|:|..:..    ||.||   .|..|:..:..::....::   .|..|.|
Zfish   383 HVFLFQDVLVITRAISHNEQLWYQ----LYRQPIPVRDLEWEDLQDGEMRVGGSI---RGAFSNN 440

  Fly  1870 YRAEKAMSEKLNFPKHTGIREASLLLVKEKCGRYTLIREPLYLDRCVVCSEADWDDYFEVQEISS 1934
            .|.:       ||           ..|..:||..|.:.          |
Zfish   441 ERTK-------NF-----------FRVMFRCGGQTQMH----------C---------------- 461

  Fly  1935 KDTFIFKAEDGVRTKQWYTQLQYHAQGMGA 1964
                 |:|.|....:||...::...:.:|:
Zfish   462 -----FQASDTFNKQQWLNCIRQAKEAVGS 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	53/185 (29%)
arhgef3	XP_005161924.1	RhoGEF	159..335	CDD:279015	52/184 (28%)
arhgef3	XP_005161924.1	PH_RhoGEF3_XPLN	349..481	CDD:269976	34/190 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.900