Protein Alignment RhoGEF64C and arhgef16

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_005167338.1
• Gene: arhgef16 / 567180
• ZFINID: ZDB-GENE-081104-446
• Length: 662
• Species: Danio rerio
• Alignment Length: 825
• Identity: 160/825 - (19%)
• Similarity: 273/825 - (33%)
• Gaps: 277/825 - (33%)

  Fly  1236 TVAELIENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQ----RIRLERQPATPGISATKEEDR 1296
            ||.:|.::|    .::...|::|.....:|..|.:..|.|    |.|..:|.....::.|   .|
Zfish    24 TVLQLDQSS----GKSASSINLSRLDSPEDERRTVVLSTQSEAARKRGTQQLIPKSLAVT---SR 81

  Fly  1297 LSNRGSISSAN----SFASAHNYELFDFDGGAG-----GNESDCYQSCSSELTASGILEEDSVSP 1352
            ..||...:...    ..||...:|.:|.|.|.|     ...:..|::..:.|...|.|:.:|:||
Zfish    82 PKNRHHTTVVTLPVPLQASEIGWEDYDSDAGDGVSLRRNRRNKSYRAAITSLHLDGELQPESLSP 146

  Fly  1353 IKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSG----DP-IYEEI 1412
            :.|              :.:|....|   :.:...:|||     ...:.:|:|    :| .|:||
Zfish   147 VSD--------------EKVVSPKQA---NKSGRKRTLG-----RIRNRKHAGSFKDEPRFYQEI 189

  Fly  1413 HEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNNPKIIEE 1477
                                                       |||||
Zfish   190 -------------------------------------------KERGL----------------- 194

  Fly  1478 EAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVGSETSKT 1542
                   ::.....||.|         :|.:.||                  .:|.|:..:..:.
Zfish   195 -------NVSSLSTEEEE---------LSPVGPP------------------GEDQGIVVKNYRA 225

  Fly  1543 SRSKYQATPTVLHLCEDCDGAVEMQVGDNGIL--YAPLVCRKCGKKRVERKEIITEIVETEEKYG 1605
            :...:...|               ||.|.|||  ..|        :..:|:|:|.||:.:|..|.
Zfish   226 AYITWSQLP---------------QVKDLGILDFITP--------EERKRQEVIFEIITSEYSYQ 267

  Fly  1606 RDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMS------LEQGDD 1664
            ..|.|::..|...:.:...:|..:...:|.|...:    |.:::|..:.||..      :|:..|
Zfish   268 HSLSILVRHFKDSVDLRKTMTATEHHHLFSNISVI----QDVSKRFFEDLDKRHQANPVIERISD 328

  Fly  1665 DLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAV-LRRMNL 1728
            .:.|.        .|:....:..||..:......|..|.......|..||  |:|.:. ...:.:
Zfish   329 IVATY--------ATKHFEPYIVYCSNETFQQRTLQKLLSSNSAFRETLK--QIETSEDCGGLPM 383

  Fly  1729 NSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQ--AQEKIELHLNHINQEAKDVPTKLWRR 1791
            .|||::|:||||:.|||:..:.:.|..  |..|..|.  |.:.|...:...|..|        ||
Zfish   384 LSFLILPMQRVTRLPLLMDTICEKTTK--ETAEYYKACWAFKAISKLVKSCNDGA--------RR 438

  Fly  1792 ISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRL-LYTQPTDSNWKKARTIKLTP 1855
            :..:........:::...||...: :....|      ....|.| :||... |.::||.:.|...
Zfish   439 MERTEQMYTIQKQMEFGKIKPFPL-VSSSRW------LKKSGELAVYTDDL-SIFRKAFSFKSYY 495

  Fly  1856 V----NALLVTNGKPSANY-----------RAEKAMSE-KLNF-----PKHTGIREASLLLVKEK 1899
            :    :.|:||..|...:|           ..|:.||: |||.     |...|..|..:|:.:.|
Zfish   496 LFLFNDVLIVTKKKSEESYVVLDYATVEKVEVEEEMSDSKLNLKLMMNPNSDGRSEQLVLVAENK 560

  Fly  1900 CGR---YTLIREPLYLDRCVVCSEADWDDYFEVQEISSKDTFIFKAEDGVRTKQ----------- 1950
            ..|   .|.:|:      ....|..|.||   :.:..:...::.||.|.:..:|
Zfish   561 LVRAQWVTALRD------VKQTSSIDNDD---LPQYEATKAYLPKAPDELSLQQAEVVIVIQEVE 616

  Fly  1951 --------------WY-----------TQLQYHAQGMGAWRKRRN 1970
                          |:           |.::.:.|.|...||..|
Zfish   617 GWCYGERMRDGERGWFPASCATQITNRTAMENNIQRMERLRKETN 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	45/194 (23%)
arhgef16	XP_005167338.1	RhoGEF	255..434	CDD:279015	45/194 (23%)
		PH_ephexin	456..577	CDD:269929	30/134 (22%)
		PH	469..574	CDD:278594	27/111 (24%)
		SH3_ARHGEF16_26	586..639	CDD:212871	5/52 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030