Protein Alignment RhoGEF64C and plekhg5a

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_009304320.1
• Gene: plekhg5a / 562861
• ZFINID: ZDB-GENE-060503-766
• Length: 1157
• Species: Danio rerio
• Alignment Length: 644
• Identity: 147/644 - (22%)
• Similarity: 252/644 - (39%)
• Gaps: 149/644 - (23%)

  Fly  1386 MDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEK--KAARSIFEGASKYDI 1448
            :||: .|.....:|:.|..|       |.    |.:.|.|..|..:|:  |..||:
Zfish   220 LDQS-NTPLSLGFEAYRFGG-------HY----LRVRARPGEDLRVERCVKDPRSL--------- 263

  Fly  1449 LSYLVDAKERGLAREESFDYGNNPKIIEEEAADTLSDL-------DKRQAEERER---------D 1497
              .|...:........|.|...:..:...||||.|..|       .|...:.|.|         .
Zfish   264 --SLPIMRSSSNTHSSSTDRAEHGSLGRREAADLLVGLVGHAAYIQKNGGQTRRRKNMPEFLGDS 326

  Fly  1498 RDSGQSSMSSLSPPPHNFICG-------GAGKSSGSDVERQDSG-VGSETSKTS--RSK-YQAT- 1550
            ..|.|.|:|.||......|.|       .|.:.||.......:| :|.|..:..  :|| |..|
Zfish   327 SISNQDSLSQLSGSLPGSITGPDRWRNRAASRFSGLFSSNSGNGSLGKECDRVEQLQSKLYSYTM 391

  Fly  1551 ------PTVLHLCEDC---DGAVEMQVGDNGILYAP--LVCRKCGKKRVERKEIITEIVETEEKY 1604
                  |..|....|.   :..:|::.....:|..|  |..|:|     .::|.|.|:::||..|
Zfish   392 FGLPKMPPQLSFHRDSWEEEPNLELEESWKQLLENPEILTRRQC-----HQQEAIWELLQTESDY 451

  Fly  1605 GRDLQIILEEFCHPML---VAGLLTQEQLSAIFLNTEDLLENNQTL-AERMRDALDMSLEQGDDD 1665
            .:.|.:|.:.|...:|   .:||||:.:.:.:|.|.:|:::.:.:| .|.|..||:.:.::
Zfish   452 IKKLHVITDLFLCGLLNLQESGLLTEVEPTRLFSNIQDIVQLHSSLWTEVMLPALEKARQK---- 512

  Fly  1666 LLTVNIGRIFLDFTQMLHAFES----------YCVRQAGASLLLANLEKEKELLRIFLKVSQMEN 1720
                   |..|:.|::...|.:          ||:.:.|....:..|.|:.||.||::..::...
Zfish   513 -------RTMLNPTELHQGFSTFGFRFKPYIRYCMEEEGCMEYMRTLLKDNELFRIYVTWAETHK 570

  Fly  1721 AVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVT---PSHLEGRELLKQAQEKIELHLNHI----- 1777
            . ..|:.|...|:.|.||:|||||||..:.|.|   |:    ||.:.:....:|..:|.:
Zfish   571 Q-CNRLKLTDMLVKPHQRLTKYPLLLKSVLKKTDDPPT----REAINRMVAAVECFINSVDSQMR 630

  Fly  1778 NQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTD 1842
            ::|.|.....:..||.:......||.|::.|          :.|:|:    |.:...::...|.:
Zfish   631 HREEKQKLAAIAGRIEAYEAVEGASEEVERI----------LKEYNN----FDLMAPVMGAPPEE 681

  Fly  1843 SNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASLLLVK--EKCGRYTL 1905
                   |.:|....||.:..||.|             ....:..:....||:.|  ::..:..:
Zfish   682 -------TRQLLLEGALKMKEGKES-------------RMDVYCFLFTDVLLITKPVKRVEKVKV 726

  Fly  1906 IREPLYLDRCVVCSEADWDDYFEVQEIS----SKDTFIFKAEDGVRTKQWYTQLQYHAQ 1960
            ||:||.:.. |||.|......|.:..::    :..::.|:|..|.:.:.|...: |:||
Zfish   727 IRQPLVIHN-VVCRELKDPGSFLLIYLNEFGCAVASYCFQANSGAQGRSWIEAI-YNAQ 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	54/207 (26%)
plekhg5a	XP_009304320.1	UNC-79	<52..>126	CDD:291442
		RhoGEF	440..626	CDD:279015	54/201 (27%)
		PH_PLEKHG5_G6	683..781	CDD:270064	22/112 (20%)
		PH	685..779	CDD:278594	22/107 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810