Protein Alignment RhoGEF64C and arhgef12a

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_009290006.1
• Gene: arhgef12a / 562455
• ZFINID: ZDB-GENE-121017-3
• Length: 1357
• Species: Danio rerio
• Alignment Length: 1265
• Identity: 247/1265 - (19%)
• Similarity: 435/1265 - (34%)
• Gaps: 379/1265 - (29%)

  Fly   894 KSNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLP----HEINKSPLSPQRTVVRVAPFKPQ--- 951
            :|..||....|..|  :.||...||.     :.||    ||.:.:.:..|::...||..:|:
Zfish     5 RSTVSDRTSSFLSR--DHPPDKRPKS-----DKLPGTPTHEFDPTDVLVQKSGCVVADRRPESCG 62

  Fly   952 --------QQQVGG-----SGDG--FTHEVHR---------------LKI--------SHSE--- 975
                    |:...|     |||.  |...|.:               :|:        :|.|
Zfish    63 LVQRCVIIQKDENGFGLTVSGDNPVFVQLVKQDGAAMRAGVQTGDRIIKVNGTLVTQSNHVEVVK 127

  Fly   976 ------------------------EDADLGVELRRRPNL----FLSSPGEEDAAPKKTSILISGD 1012
                                    .:.|:|:|   .|::    |::||...:||.:.:|.|:|.:
Zfish   128 LIKSGSYVALTVLGRPPGLPQIPLPEVDVGLE---SPDVFGDPFITSPNSYNAAERTSSPLVSWE 189

  Fly  1013 DCYSTMNLSANA-------AQPLYQSSVVVNSHSATSVCISVSSAEEQEQELNQLNTLRSQQMGM 1070
            :..:..|...::       .|...:|..:.||...       |.|||.:.:    .....:....
Zfish   190 ENSALHNQRMDSRRTGLKDQQDTQESPCLRNSEDG-------SWAEEDQYK----RDFSPEAFWS 243

  Fly  1071 GIAIIPIRG---ASEVNLQRSVSCISSTSSSSTSSSSSSSGRGRTLIRLDY--DRERKGSATSST 1130
            |.::..:..   .:....||..:|.|..|:...|.:|..|.      .:||  |.:.:..:|..:
Zfish   244 GNSVPSVHRRFYPASPESQRDSNCSSPKSTPRDSFNSCPSP------EVDYGSDLDSRFPSTVGS 302

  Fly  1131 PINTPPVISSTPATPPPTDLPIENANP----------LVPHETELLKILRNPVEAVKLNLVPHVC 1185
            |.....:|:   |.....|...|..|.          |......|...|.:.:.  :.:..|.:|
Zfish   303 PRLVSEIIA---AEDDDFDSEQEQVNGQCSCFQSIQLLKTRPAHLAAFLHHVIS--QFDPAPLLC 362

  Fly  1186 GLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETE-TVAELIENSLQRLQ 1249
            .|.|...:...||:.:                ::..|.:...:..|...: ||.|.|.:.|:|
Zfish   363 YLYADLYKQTNSKETR----------------RIFTDFLTFFIDRGANLKVTVPESISSELER-- 409

  Fly  1250 QARRGIDMSGTKDHDDMNRLISASLQR--IRLERQPATPGISATKEEDRLSNRGSISSANSFASA 1312
              ||             ..||...|.|  |:..::...|.:....|:.|......::.|::..|.
Zfish   410 --RR-------------PELIPEELHRQYIQTMQETLFPDVQRNLEDFRQKRSMGLTLADTELSR 459

  Fly  1313 HNYELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPETELDAAT------------- 1364
            .:.|....|     .|..|.:|..|::        |.|.....|..|...:|
Zfish   460 LDSEQLAVD-----RERACAESILSKI--------DDVLLTSQPTEEEKCSTIQYVIFMYMKHLG 511

  Fly  1365 -RAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLP--LSAPP- 1425
             ||| .|..:::....|.......:...|:.:.. |.::.|..||     .|||..|  |.:.|
Zfish   512 VRAK-EQRNLESKRVRINFLPSKLRKSKTEKDGE-EKLKKSRFPI-----RVPPRWPGRLDSVPS 569

  Fly  1426 --LNDA---ELEKKAARSIFEGASKYDILSYLVDA-KERGLAREESFDYGNNPKIIEEE----AA 1480
              :.|:   ..:|:.::....|       |.|:|| :.||....|..|..::|.:|...    ..
Zfish   570 GRVGDSIKQRPQKQMSQPALGG-------SELIDAGRLRGSQSSEGSDLLHSPGLITSSPFSAPY 627

  Fly  1481 DTLSDLDKRQAEER-------ERDRDSGQSS--MSSLSPP----PHNFICGGAGKSSGSDVERQD 1532
            .:.||...|.:|..       .|..|..||.  :.|:.||    |:|             |::.|
Zfish   628 SSPSDPSGRDSEFNMSPSAVVPRLSDGLQSGDPLDSIYPPCDYIPYN-------------VDQLD 679

  Fly  1533 SGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPL------------VCRKCGK 1585
                 |.....|.....||......||    ::.:......:|:.:            |......
Zfish   680 -----EDRDGDRPPDVGTPKPSRRFED----LQSEDDQGSDVYSDVDPPNWQQLVGRDVLAGLTP 735

  Fly  1586 KRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLE-------- 1642
            ..::|:|:|.|:..||..:.|.|:::.:.|...:....:|....:..||.|.|::::
Zfish   736 HEIKRQEVINELFYTERAHVRMLKVLDKVFYQKLNRDNILPPADIKYIFTNLEEIIQLHVRIVDQ 800

  Fly  1643 -------NNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLA 1700
                   |..::.:.:.|.|......|:::.:...:|              ::|..|..|..|:.
Zfish   801 MTAICKKNETSVIDHIGDELLSWFSSGEEEKIKQAVG--------------TFCSNQPFALELIK 851

  Fly  1701 NLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQ 1765
            :.:|:.:....|::.:: .|.:.||:.|...:...:||.||||||:..:.|.| ...|.::.:::
Zfish   852 SRQKKDQRFSSFMQEAE-SNRLCRRLQLKDIIPAEMQRFTKYPLLMDNIAKYT-DESEEKDKVRR 914

  Fly  1766 AQEKIELHLNHINQEAKDVPTK-----LWRRISSSSPNRRAS---CEIDMINIKLRKMAIDVLEW 1822
            |.|.....|||:||..|:...|     ..||:..||..:..:   .|...:::..|||.
Zfish   915 AAECCRQILNHVNQSVKESENKQRLEDYQRRLDLSSLKQSENPMISEFKNLDLTKRKMV------ 973

  Fly  1823 NHDEVRFAMEGRLLYTQPTDSNWK--KARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLNFPKH 1885
             |       ||.|        :||  |.:||:|                               :
Zfish   974 -H-------EGPL--------SWKINKDKTIEL-------------------------------Y 991

  Fly  1886 TGIREASLLLVKEKCGRYTL---------------IREPLY-LDRCVVCSEADWDDYFEVQEISS 1934
            |.:.|..|:|::::..|..|               |..|:. |...:|.|.|..:..|.|..:|.
Zfish   992 TLLLEDILVLLQKQDERLILRCHSKNLAGTAETKHIFSPIIKLSTVLVRSVATDNRSFFVISMSK 1056

  Fly  1935 KDTFIFK--AEDGVRTKQWYTQLQYHAQGM 1962
            ....|::  |:.....:.|..|:...|:.|
Zfish  1057 NGAQIYELMAQTVSEQRMWQRQITQRAEVM 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	43/200 (22%)
arhgef12a	XP_009290006.1	PDZ_signaling	66..140	CDD:238492	10/73 (14%)
		RGS	308..524	CDD:295367	49/267 (18%)
		RhoGEF	743..928	CDD:279015	43/200 (22%)
		PH-like	947..1083	CDD:302622	35/188 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810