Protein Alignment RhoGEF64C and arhgef2

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_021328624.1
• Gene: arhgef2 / 561276
• ZFINID: ZDB-GENE-030717-1
• Length: 872
• Species: Danio rerio
• Alignment Length: 686
• Identity: 130/686 - (18%)
• Similarity: 249/686 - (36%)
• Gaps: 142/686 - (20%)

  Fly  1271 SASLQRIRLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDCYQSC 1335
            |..|.:.|.||.......:..||..:...:.:....:.:::.|.:.....      :.:....:|
Zfish     5 SEPLPKARQERMKDNNAKNKEKERMKAREKETKERESRYSNGHLFTSLSV------SATTLCSAC 63

  Fly  1336 SSELTASGILEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQ--TLGTDSEHHY 1398
            :..:||.        ..:..|...:....|.:       .|||.........|  .||.::...:
Zfish    64 NKSITAK--------EALSCPTCNVTIHNRCR-------DTLANCAKMKQKQQRLALGRNTATLH 113

  Fly  1399 ESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAAR---SIFEGASKYDILSYLVDAKERGL 1460
            .....|.:||   :.|.|......:..|..:.|..:..|   |:.:..|..:|...|.|....||
Zfish   114 NVALRSKNPI---LKERPSSAIYPSETLRQSFLGSRKGRSSLSLNKSVSTNNIAGSLNDDSPIGL 175

  Fly  1461 AREESFDYGNNPKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSG 1525
            .|            |...:.|:|:  .:.:|...|...|.|::..:|:.
Zfish   176 RR------------ILSHSTDSLN--FRNRAMSMESLNDEGETYYTSMM---------------- 210

  Fly  1526 SDVERQDSGVGSET-SKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVE 1589
            .::||......::: |....|.|..:..                                |..::
Zfish   211 EELERDGKDFAADSWSLAVDSSYLQSQR--------------------------------KDVIK 243

  Fly  1590 RKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDA 1654
            |:::|.|:::||..:.|.|:|:...|...||...::....:.|||...:.||..:.....::...
Zfish   244 RQDVIYELIQTEFNHVRTLRIMEGVFRRGMLEEVMMEMGVVHAIFPCLDQLLLIHTNFLSQLLQR 308

  Fly  1655 LDMSLEQGDDDLLTV-NIGRIFLD-FT-----QMLHAFESYCVRQAGASLLLAN-LEKEKELLRI 1711
            ...||....:...|: .:|.|.:: |:     .|...:..:|.|...|..|... |.::|...:.
Zfish   309 RSNSLASNSNRNFTIQKLGDILVEQFSGQNAEDMRKCYVEFCSRHLKAVKLYKELLARDKRFQQF 373

  Fly  1712 FLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNH 1776
            ..:||:  .::|||..:...:::..||:||||:|:.|:...|..:.|..:.|.|:...|...|..
Zfish   374 IRRVSR--GSLLRRHGVQECILLVTQRITKYPVLMQRILDNTKGNEEESKSLAQSLTLIRELLCS 436

  Fly  1777 INQEAKDVPTKLWRRISSSSPNRRASCEIDMINI-----KLRKMAIDVLEWNHDEVRFAMEGRLL 1836
            ::|:.:::......:...|..:.||..::....:     .||:..|.             ||.||
Zfish   437 VDQQVQELERAQRLQEIQSRLDPRAETKVKGGGVFHGAELLRRGLIH-------------EGALL 488

  Fly  1837 YTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASLLLVKEKCG 1901
                    ||.|:..:|..|:.||:|:   ...:..||  .:|..||.   :.:.|:|     |.
Zfish   489 --------WKTAQGSRLKDVHVLLMTD---VLVFMQEK--DQKYVFPT---LDKPSVL-----CL 532

  Fly  1902 RYTLIREPLYLDR-CVVCSEADWDDYFEVQEISSKD 1936
            :..::|:.....| ..:.|.:...:.:|:...|..|
Zfish   533 QNLIVRDIANQQRGMFLISHSTPPEMYELHAASKDD 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	47/193 (24%)
arhgef2	XP_021328624.1	C1	47..92	CDD:237996	8/65 (12%)
		RhoGEF	244..438	CDD:238091	48/195 (25%)
		PH-like	478..595	CDD:327399	28/125 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900