Protein Alignment RhoGEF64C and arhgef3l

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_005162130.1
• Gene: arhgef3l / 553761
• ZFINID: ZDB-GENE-050522-85
• Length: 532
• Species: Danio rerio
• Alignment Length: 621
• Identity: 133/621 - (21%)
• Similarity: 232/621 - (37%)
• Gaps: 156/621 - (25%)

  Fly  1411 EIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNNPKII 1475
            |..|....|..|..|:....|...|..|.|.|             |:|  .::.|.|..|:.:|:
Zfish     7 EPEETEVDLSSSWSPITRERLLTCANLSDFAG-------------KKR--KQDPSSDAENSARIL 56

  Fly  1476 EEEAADTLSDLDKRQAEE-----RERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGV 1535
            |:...|.....|..|..|     |.:..|.|.|....::|     :...|.|..|..::|   .:
Zfish    57 EDCEEDDFPISDHMQDSEGPCNKRVKPVDKGASVTGIITP-----VKTPALKRLGQSIQR---SI 113

  Fly  1536 GSETS-------KTSRSKYQATP----------TVLHLCEDCDGAVEMQVGDNGILYAPLVCRKC 1583
            ...|.       ..||.|..:.|          ||                ||       :..:.
Zfish   114 SFRTEARPLPPMPRSRQKASSFPRRRSSQLWSDTV----------------DN-------MSHEL 155

  Fly  1584 GKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLA 1648
            ..|.::|:|:|.|:.:.|::...||.::.:.:..|||...::|:.:|..||...:.|:..::.|.
Zfish   156 STKEIKRQEVIYELTQGEKQLIEDLSLVKKVYYEPMLKLDIMTESELGQIFGTLDSLIPLHEDLL 220

  Fly  1649 ERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLANLEKEKELLRIFL 1713
            .|:...      :|.:..:. .:|...:|:...|.|:.:||..|.||..||...:::|.:.: ||
Zfish   221 VRLEGL------RGAEKTVQ-EVGPTMMDWFPCLEAYITYCCNQVGAKALLDQKKQDKRVEQ-FL 277

  Fly  1714 KVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHIN 1778
            ::.| |::..|:::|.:||.:|..|:.||||||..:.|.||......:.|.||.|.|:..:..:|
Zfish   278 RLCQ-ESSFSRKLDLWNFLDLPRSRLVKYPLLLKEIQKSTPLDHPDEDALPQAMELIQRIITEVN 341

  Fly  1779 QEAKDVPTKLWR----------RISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEG 1833
            .:..:...:.:|          |::....:|...|..::.:.|.:|:.:           |..|.
Zfish   342 LKTGEAECQFYRRGLCYAEDSQRVAEIQASRFLYCHGELKSTKGQKLHV-----------FLFEL 395

  Fly  1834 RLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASLLLVKE 1898
            .|:.|:|...:       :..||...:.....|:|:...|.....:   |..:|...
Zfish   396 VLVLTRPVAQD-------REGPVQFQVYRQPMPAAHLHLEDLPDGE---PSSSGSFR-------- 442

  Fly  1899 KCGRYTLIREPLYLDRCVVCSEADWDDYFEVQEI--SSKDTFIFKAEDGVRTKQWYTQLQYHAQG 1961
              |.:|      ..|:...|        |.|...  |...:...:|.|....:||.:.|:   |.
Zfish   443 --GAFT------GNDKVKNC--------FRVSTTGRSKSQSHSLQANDSFNKQQWISCLR---QA 488

  Fly  1962 MGAWRKRR-------------------NALANIMIN 1978
            |...|.|:                   |.:|.:.||
Zfish   489 MVQSRDRQAQSSPCNPNERLSPEPALYNNIAELTIN 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	52/185 (28%)
arhgef3l	XP_005162130.1	RhoGEF	165..341	CDD:279015	52/184 (28%)
		PH_RhoGEF3_XPLN	355..489	CDD:269976	30/181 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940