DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and arhgef16

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_012822093.1	Gene:	arhgef16 / 549614	XenbaseID:	XB-GENE-1015007	Length:	715	Species:	Xenopus tropicalis

Alignment Length:	945	Identity:	170/945 - (17%)
Similarity:	297/945 - (31%)	Gaps:	357/945 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1099 STSSSSSSSGRGRTLI--RLDYDRERKGSATSSTPINTPPVISSTPATPPPTDL------PIENA 1155
            |..:|.||.|...:|:  |..|..|.|.|||..            ||....||:      |::||
Frog     2 SQRNSDSSLGEKSSLLFDRKKYASEFKKSATLG------------PAVTRRTDVSRRTLEPVDNA 54

  Fly  1156 NPLVPHETELLKILRNPVEAVKLNLVPHVCGLRAP-TRESGKSKKIQEEEVSGTPVKDP---GFI 1216
            : .:|.:      :.:||||.::     :...::| ..:.|..:.|.:.....|..|.|   .|.
Frog    55 S-YIPEQ------IPSPVEASRV-----ILSTQSPAAHKLGTQQMIPKGLAVATKTKVPRHHSFA 107

  Fly  1217 AKLLQDPMLGQVAEGLETETVAELIENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLER 1281
            |                |....||..|..:|:......:|:|    .||::  ...:|:|
Frog   108 A----------------TTFTKELARNDPKRISAPDICLDLS----EDDLD--TGGTLKR----- 145

  Fly  1282 QPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSELTASGILE 1346
                          .|.|:...::...|   .|:|           :|:..:..|:.:..|   |
Frog   146 --------------NLRNQSYRAAMKGF---QNFE-----------DSEPQKPVSTLMPVS---E 179

  Fly  1347 EDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSG----DP 1407
            :.||.|.:.|       .|:|                    :|.|.....     ||:|    ||
Frog   180 DASVPPPRSP-------GRSK--------------------KTFGRKRMQ-----RHAGSFKDDP 212

  Fly  1408 -IYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNN 1471
             :|:|.                                           :||||       ..||
Frog   213 RLYQEF-------------------------------------------RERGL-------NSNN 227

  Fly  1472 PKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVG 1536
                 :|:.|.|.| :|.:||:                |.|                   |.|:.
Frog   228 -----QESDDDLLD-EKGEAEQ----------------PVP-------------------DDGIV 251

  Fly  1537 SETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETE 1601
            .:..:.::..:...|               :|.::|||      .|...:..:|:|.|.||:.:|
Frog   252 VKNYRPAQLIWSQLP---------------EVQESGIL------NKISPEERKRQEAIFEIITSE 295

  Fly  1602 EKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDL 1666
            ..|...|.|::..|.....:...:|..:...:|.|..::.|.::...|      |:.....::..
Frog   296 YSYQHSLGILVRLFKKSEELKQTITNTEHHHLFSNIAEIQEVSKRFFE------DLEKRHKENPF 354

  Fly  1667 LTVNIGRIFLDFTQ-MLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNS 1730
            :. ||..|.....| ....:.|||..:......|..|.......:..||..:|: |....:.:.|
Frog   355 ID-NISDIVEHHAQNKFQPYVSYCSNEMYQQRTLQRLMSTNGTFKDTLKQIEMK-AECGGLPMFS 417

  Fly  1731 FLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQ--EAKDVPTKLWRRIS 1793
            ||::|:||||:.|||:..:.                 :|:::......:  .|....:||
Frog   418 FLILPMQRVTRLPLLMDTIC-----------------QKMDMRTKEYGETTHALKALSKL----- 460

  Fly  1794 SSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNA 1858
                       :...|...|||.               ....:||..|...:.|.:...|...:.
Frog   461 -----------VKQCNEGARKME---------------RTEQMYTLQTQLEFGKIKPFPLISASR 499

  Fly  1859 LLVTNGKPSANYRAEKAMSEKLNFPKHTGI-----REAS---------LLLVKEKCGRYTLIREP 1909
            .|:..|              :||..:.:|:     .:.|         |::.|:|.....::.:.
Frog   500 WLLKRG--------------ELNLVEESGVFWKGFGKTSCYLFLFNDILIITKKKSEENYIVTDY 550

  Fly  1910 LYLDRCVVCSEADWDD--------------------YFEVQEIS-----SKDTFIFKAEDGVRTK 1949
            :.:|:..|....:.|.                    .|:: .||     .:|..:..|:......
Frog   551 VMMDQFAVAKIENGDPQLSPPAKTGTSGPRSPNGPFLFQI-HISKNSEGKQDEIVLAADSLSDRA 614

  Fly  1950 QWYTQLQYHAQGMGAWRKRRNALANI-MINGMLAR 1983
            :|...|:.........|.||..|..: :|...||:
Frog   615 RWVAALERKEDNKENSRSRRGGLRQVEIIKAYLAK 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	39/186 (21%)
arhgef16	XP_012822093.1	RhoGEF	287..465	CDD:366202	42/218 (19%)
		PH_ephexin	488..627	CDD:269929	21/153 (14%)
		SH3_ARHGEF16_26	639..692	CDD:212871	3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030