Protein Alignment RhoGEF64C and ARHGEF35

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: NP_001003702.2
• Gene: ARHGEF35 / 445328
• HGNCID: 33846
• Length: 484
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 109/546 - (19%)
• Similarity: 172/546 - (31%)
• Gaps: 179/546 - (32%)

  Fly  1172 PVEAV-KLNLVPH---------VCGLRAPTRESGKSKKIQEEEVSGTPVKD------------PG 1214
            |:.|: :.:::|.         ..||.|...|....|..:|..:|.|...:            |.
Human    13 PISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQQSELRDVCDYAIETMPS 77

  Fly  1215 FIAKLLQDPMLGQ---VAEGLETETVAELIENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQR 1276
            |..:...|....|   |||..:|....|.:..||.. :|||....          ..|.:..:|.
Human    78 FPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAG-RQARTLAP----------PELWACPIQS 131

  Fly  1277 IRLERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSELTA 1341
            ..|:..|                                  |..|.|:...|.:.:...:|....
Human   132 EHLDMAP----------------------------------FSSDLGSEEEEVEFWPGLTSLTLG 162

  Fly  1342 SGILEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGD 1406
            ||..||:.       ||..|.:.:.::|....       ||....:|..|.:|    .:||...:
Human   163 SGQAEEEE-------ETSSDNSGQTRYYSPCE-------EHPAETNQNEGAES----GTIRQGEE 209

  Fly  1407 PIYEEIHEVPPPL-PLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGN 1470
            ...||:.|....| |.....|.:...::...|.  ||..:.|:.:       .||..||
Human   210 LPSEELQESQGLLHPQEVQVLEEQGQQEAGFRG--EGTLREDVCA-------DGLLGEE------ 259

  Fly  1471 NPKIIEEEAADTLSDLDKRQAEERERDRD---SGQSSMSSLSPPPHNFICGGAGKSSGSDVERQD 1532
              ::||:     ::|....|.:::|:.:|   ..|.....|:..|...   ..|:....|:||:.
Human   260 --QMIEQ-----VNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGL---NDGEWEQEDMERKA 314

  Fly  1533 SGVGSETSKTSRSKYQATP-------------TVLHLCEDCDG------------------AVEM 1566
            .|.|.......|.:....|             |.|...|:..|                  |.|.
Human   315 QGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQEAKEP 379

  Fly  1567 QVGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIIL--EEFCHPMLVAG---LLT 1626
            :..|.|.|.|      .|:.|...:|        .|.:|..:..::  |:..|..|..|   |:|
Human   380 ESWDGGRLGA------VGRARSREEE--------NEHHGPSMPALIAPEDSPHCDLFPGASYLVT 430

  Fly  1627 Q----------EQLSAIFLNTEDLLE 1642
            |          |:||...|:  .|||
Human   431 QIPGTQTESRAEELSPAALS--PLLE 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	16/65 (25%)
ARHGEF35	NP_001003702.2	ARHGEF5_35	1..478	CDD:317795	109/546 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..418		67/335 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900