DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and Arhgef19

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001102162.1	Gene:	Arhgef19 / 362648	RGDID:	1304766	Length:	888	Species:	Rattus norvegicus

Alignment Length:	808	Identity:	155/808 - (19%)
Similarity:	253/808 - (31%)	Gaps:	325/808 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1109 RGRTLIRLDYDR--------ERKGSATSSTPINTPPVISSTPATP-------------------- 1145
            :|.:|.||...:        :|||......|....|.::..|.|.
  Rat    58 QGSSLPRLSTAQPGKCPGGWQRKGGMDCGPPATLQPHLAGPPGTARRPVAVCQQESLSFVELPTL 122

  Fly  1146 -PPTDLPIENANPLVPHETEL------------LKILRNPVEA---------------VKLNLVP 1182
             ||:.:.:: ..|:.|.|.:.            |:.|..|..:               .:....|
  Rat   123 HPPSPVCVD-LFPITPEELQAPGSRWSLATPAPLQGLLWPTSSGGPDTHISTTGGMRPSRAGSWP 186

  Fly  1183 HVCGLRAPT--------------------RESGKSKKIQ----EEEVSGTPVKDPGFIAKLLQDP 1223
            |..|.:.||                    .|....:|:|    ||...||            :.|
  Rat   187 HCPGAQPPTLVGPWSSQHMQPQRRASHGGSEKSAWRKMQVYHNEEATGGT------------EPP 239

  Fly  1224 M----LGQVAEG----LETETVAELIENSLQRLQ-QARRGIDMSGTKDHDDMNRLISASLQRIRL 1279
            |    .||..:|    .:.....||..|:...|: |.||....|     :.|.||.|:    :||
  Rat   240 MGLLETGQAVQGQALCAQEPRPQELSGNTRGGLEAQERRRFSAS-----ELMTRLHSS----LRL 295

  Fly  1280 ERQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSELTASGI 1344
            .|..|...:::                                |:|                :|:
  Rat   296 GRSTAPRALTS--------------------------------GSG----------------AGV 312

  Fly  1345 LEEDSVSPIKDP---ETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGD 1406
            :.|..: |.::|   ||.:|:.:      |.....|.|::...
  Rat   313 IREGKL-PGREPRRAETRMDSVS------LPAPVDLNEVQGGL---------------------- 348

  Fly  1407 PIYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNN 1471
                    |.|.|..:..|..|..                       .|.||   |:..|...:
  Rat   349 --------VEPRLDTNDKPTQDTN-----------------------SATER---RQSRFLLNS- 378

  Fly  1472 PKIIEEEAADTLSDLD-KRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGV 1535
              ::.:|.:|..|..: :||..|.|...|..:.:.....||..|.       |..|....|.|..
  Rat   379 --VLYQEYSDVASARELRRQQREEEGPGDGAEGAEEGPGPPRANL-------SPSSSFRAQRSTR 434

  Fly  1536 GSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVET 1600
            ||     :.|.:|..|               .|..:|:| |.|..|.|     :.:|...|::.:
  Rat   435 GS-----TFSLWQDIP---------------DVRGSGVL-ATLSLRDC-----KLQEAKFELITS 473

  Fly  1601 EEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTED------LLENNQTLAERMRDALDMSL 1659
            |..|...|.:.:..|         |...:||.. |.|:|      .|...::.:||....|:..|
  Rat   474 EASYIHSLSVAVGHF---------LGSVELSEC-LGTQDKQWLFSKLPEVKSTSERFLHDLEQRL 528

  Fly  1660 EQGDDDLLTVNI-----------GRIFLDF-TQMLHAFESYCVRQAGASLLLANLEKEKELLRIF 1712
            |.   |:|..::           .|::|.: |...:...:|      ..|||.|.:....|.|:
  Rat   529 EA---DVLRFSVCDVVLHHCPAFRRVYLPYVTNQAYQERTY------QRLLLENPKFPGILARL- 583

  Fly  1713 LKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYK-VTPSHLEG----------RELLKQA 1766
                 .|:.|.:|:.|.|||::|.||||:..:|:..:.| .||...:.          :||:::.
  Rat   584 -----EESPVCQRLPLTSFLILPFQRVTRLKMLVENILKRTTPGSQDEDMATKAFSALKELVQEC 643

  Fly  1767 QEKIE--------LHLN-HINQEAKDVP 1785
            ...::        :||: .|:.|.|..|
  Rat   644 NASVQSMKRTEELIHLSKKIHFEGKIFP 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	50/223 (22%)
Arhgef19	NP_001102162.1	RhoGEF	468..645	CDD:279015	47/201 (23%)
		PH_ephexin	666..792	CDD:269929	3/6 (50%)
		PH	679..786	CDD:278594
		SH3	805..859	CDD:302595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900