DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and Y105E8A.25

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001300405.1	Gene:	Y105E8A.25 / 3564893	WormBaseID:	WBGene00013682	Length:	1619	Species:	Caenorhabditis elegans

Alignment Length:	1602	Identity:	289/1602 - (18%)
Similarity:	486/1602 - (30%)	Gaps:	591/1602 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   546 SSSTPMATSTPTPNASITATTAAAGAAITPGSRKKVQFMVEDKIIATTATAATTDDSDASAVATK 610
            :||.|...|:|.|.               |....::.|.:.::                   ::.
Worm     8 ASSLPPLPSSPPPE---------------PVDPTRITFTLSNE-------------------SSS 38

  Fly   611 TNYEYYNRKRNAATATAAAATAASAAAASPPTAATSTDQQEATLFAADIDDEHNFTTSGEAAPP- 674
            ..||:.|      ..|:::.:..|....:.|......|:::...|.||...|.:.:.:...:||
Worm    39 PRYEFNN------LVTSSSPSYFSYQPYTSPGIYLLPDREQQPYFGADFQTESSISWNSPTSPPP 97

  Fly   675 --------------FIKP----------DSL--------HYEDVLPGPQIFDSSESSAKL--SLP 705
                          ..:|          |||        |:.||:......|.|.|...|  :..
Worm    98 PPMIVEEEMRSGGGTARPVTPRSIANSLDSLSECAQHHHHHSDVVNANSNSDRSRSLGDLLAATM 162

  Fly   706 ADGS-PHVTTSPVSVLPTGTSNGVG--GAGLGPGPAGVSGEEAPATAAATAAATQKTTAANRDYD 767
            .||: ..:.......|.|.|:.|.|  .:|:|.|...:.||:                    :.|
Worm   163 QDGNDDSLRNGSYDTLVTTTTKGGGLTDSGIGGGLLLMKGED--------------------EMD 207

  Fly   768 DDDEHNDKDE-SHDNKPNDLAERE-------QDREGDKEQGRAGELGISRQEKKDAGGKPAASQK 824
            ..|:||.... .|...|.|::..:       .....|...|              :|..|:.|
Worm   208 IMDDHNSSSSPDHHRIPTDISSPDSFTYPPVSFTSYDPVNG--------------SGSVPSYS-- 256

  Fly   825 RAAQTTQSRNPIRRAHSERHLSTAPLAAHGHASSACAAGRNCHSIPMTPPASGPQNVILNFKDTM 889
                 .::.||         |.:.|   .||:    |..|....:|.....|.        .:..
Worm   257 -----NENTNP---------LDSTP---RGHS----ADDRKHSDLPAISEESE--------HEQQ 292

  Fly   890 ALRIKSNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLPHEI--NKSPL-----SPQRTVV---R 944
            ::.|..|..               ||.....|.|..|...|:  :..|:     :|..||.   |
Worm   293 SIHIPYNHY---------------PPHSSSVGPGAAPAVREVVEHTYPMVHCNSAPSNTVFNSDR 342

  Fly   945 VAPFKPQQQQVGGSGDGFTHEVHRLKISHSEEDAD----LGVELRRRPN------------LFLS 993
            :|..:.....|        .|..|||.|...|:.|    :..|.|....            :|.:
Worm   343 IAHRRVVSDDV--------TETTRLKRSEELENMDKVGRISFEKRSASTNHLSKSRKGATLVFHN 399

  Fly   994 SPGE----------EDAA---PKKTSILI----SGDDCYSTMNLSANAAQPLYQSSVVVNSHSAT 1041
            .|.|          ||||   .|...:||    .|::.|...::......||..    .::||..
Worm   400 DPNEKDETDDEEEYEDAADGYSKDNEMLILEKSGGEERYRMASVKKKNGSPLRH----FDNHSNL 460

  Fly  1042 SVCISVSSAEEQEQELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSVSCISSTSSSSTSSSSSS 1106
            :   |:||.|..                      |:|      |.|.||.:||||.||...::..
Worm   461 T---SISSTEPP----------------------PVR------LPRRVSAVSSTSRSSPQRATDQ 494

  Fly  1107 SGRGRTLIRLDYDRERKGSATSSTPINTPPVISSTPATPPPTDLPIENANPLVPHETELLKILRN 1171
            |.:.:                      .||......:...|..||..:|.|..|.:
Worm   495 SWKDK----------------------MPPFGIVGHSMYSPQSLPSRDAIPRTPFD--------- 528

  Fly  1172 PVEAVKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETET 1236
                             ..|..||.|..|                             .|.:.:.
Worm   529 -----------------GSTISSGASSNI-----------------------------GGSQRQF 547

  Fly  1237 VAELIENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLSNRG 1301
            ..|:.                  :.|.|:                   ||. |......||....
Worm   548 SHEVT------------------SPDGDE-------------------TPD-SRYSTSSRLYENH 574

  Fly  1302 SISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSE--LTASGILEEDSVSPIKDPETELDAAT 1364
            ||||..:..:|   ||.|       :.....:.|.:.  ..:|.|..|.|.||  .|:::...|.
Worm   575 SISSPTALLAA---ELTD-------DLMPLSEICKNHRLSISSSINTEHSQSP--PPKSQSGGAP 627

  Fly  1365 RAKFYQLLVDATLAEI-EHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLND 1428
            .:.|    |..:|.:| :..:.....||.|     |.:|                         :
Worm   628 NSSF----VRRSLRKIMKRGSVSTSALGGD-----EGLR-------------------------N 658

  Fly  1429 AELEKKAARSIFEGASKYDILSYLVDAKERGLAREES-------------------FDYGN---- 1470
            ..|:::|:     ..|.    |:...|:||...|.:|                   |.:||
Worm   659 GSLKRRAS-----NVSS----SFFASAQERLRPRAKSLKKQRIGKNAKKEKSGSDTFTFGNLFRK 714

  Fly  1471 NPKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHN-----------FICGGAGKSS 1524
            .|.......||.:||||:|..        :|.....|||....|           ...||...::
Worm   715 KPPTSRPNLADIISDLDQRST--------TGGRGGGSLSAGATNRRSTSATILPMSSAGGCDPTT 771

  Fly  1525 GSDVERQDSGVGSETSK---TSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGK- 1585
            ..|......|:....|:   .|.|.:.||.:     ...:||..|     ..||..| .|..||
Worm   772 PFDSACSLDGLPDHISRMVSPSDSPHHATSS-----STLNGANSM-----SSLYVQL-DRIYGKH 825

  Fly  1586 ----------------------KRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQE 1628
                                  |:|::::.|.|:...|:::..::..:|..:...||...::|::
Worm   826 DLFANDEYQSWHEKYRHNTLSTKQVKKQDAIFELYLMEKRHCANIAFLLHGYRRRMLDENIITKQ 890

  Fly  1629 QLSAIFLNT-EDLLENNQTLAERMRDALDMSLEQGD-DDLLTVNIGRIFLDFTQ----MLHAFES 1687
            .:..:..:. |.||..:..:.||:...:..:.|.|. .|:::..:.   :|..|    ...|:..
Worm   891 DMDVLIPDVLEPLLIFHLNVLERITARMKENYEVGTISDIISEELA---IDGGQHTKLCCDAYTD 952

  Fly  1688 YCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKV 1752
            :.|.:..:.:|..:|..:......|.|.:..|....:..:....:...:.|.|||.|||..:.|.
Worm   953 FGVAKERSDVLYHHLMNKNAKFAEFFKKTYSEETFYKHYDFRPLITKIIGRATKYSLLLETILKN 1017

  Fly  1753 TPSHLEGRELLKQAQE-------KIE--LHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMI 1808
            .....|..:|.|.|.|       ||:  |.:.|::.:.::    |..:|.|||.......:..:.
Worm  1018 EQPFSEYHDLTKTALETARKFAHKIDGNLSMAHMSMKWEE----LKAQIDSSSATTLYVSDPSVA 1078

  Fly  1809 NIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAE 1873
            |..:|      ..::.|.:..|...:|::....        .||: |||.:....|..|::...:
Worm  1079 NATIR------YTFDLDSLNSATNRKLVHLGEA--------LIKI-PVNPVGSGGGTHSSSSGKQ 1128

  Fly  1874 --------------------KAMSEKLNFPKHTGIREASLLLVKEKCGRYTLI----REPLYLDR 1914
                                :..|.:|.|.:..|:.....||::.....::::    .:|:
Worm  1129 VDKKDQCYIVLFDDIIVILIRKSSRQLIFMQDQGVMPVQSLLIRTAARGHSIMLISGAKPV---- 1189

  Fly  1915 CVVCSEADWDDYFEVQEISSKDTFIFKAEDGVRTKQWYTQLQ 1956
                       .||:...:|.|           .|:|.|.|:
Worm  1190 -----------LFEISFHTSTD-----------RKKWVTLLE 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	41/200 (21%)
Y105E8A.25	NP_001300405.1	RhoGEF	852..1043	CDD:238091	38/193 (20%)
		PH_16	1095..1211	CDD:375371	23/150 (15%)
		OmpH	<1540..>1591	CDD:214922
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900