DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and Plekhg5

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_038965663.1	Gene:	Plekhg5 / 310999	RGDID:	1303132	Length:	1101	Species:	Rattus norvegicus

Alignment Length:	805	Identity:	180/805 - (22%)
Similarity:	294/805 - (36%)	Gaps:	242/805 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1296 RLSNRGSISSANSFASA-HNYELFD----FDGGAGGN---ESDCYQSCSSELTASGILEED---- 1348
            :|.:||.::......|. ||...:|    ||....|:   .:...:||....:.:|.|||:
  Rat    79 QLHHRGPLNLCEICDSKFHNTTHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAGDLEEEDEGY 143

  Fly  1349 ------------SVSPIK-------DP---------------ETELDAATRAKFYQLLVDATLAE 1379
                        .:|..|       ||               |||:..|.:.|        :|.|
  Rat   144 TNGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKK--------SLGE 200

  Fly  1380 I-------------EHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAEL 1431
            :             :...::||: .|.....:|:.|..|       |.    |.:.|.|.::.::
  Rat   201 VLLPVFERKGIALGKVDIYLDQS-NTPLSLTFEAYRFGG-------HY----LRVKAKPGDEGKV 253

  Fly  1432 EK--KAARSIF------EGASKYDILSYLVDAKERGLAREESFDY---GNNPKIIEEEAADTLSD 1485
            |:  |.::|:.      .||.. .:|. .||.:.|   ||.|.|.   |...|.:.|...||
  Rat   254 EQGVKDSKSLSLPALRPSGAGT-PVLE-RVDPQSR---RESSLDILAPGRRRKNMSEFLGDT--- 310

  Fly  1486 LDKRQAEERERDRDSGQSS--MSSLSPPPHNFICGGAGKSSGSDVERQD------SGVGSETSKT 1542
                        ...||.|  .||.|.|     .|.:..||||....::      ||..|.:..|
  Rat   311 ------------SIPGQESPAPSSCSLP-----VGSSVGSSGSSESWKNRAASRFSGFFSSSPST 358

  Fly  1543 SR-----SKYQATPTVLH-------------LCEDCDGAVE----MQVGDNGIL----------- 1574
            ..     .|.:...:.||             |..|.|...|    .:..||..|
  Rat   359 GAFGREVDKMEQLESKLHAYSLFGLPRMPRRLRFDHDSWEEEEDDEEEEDNSGLRLEDSWRELID 423

  Fly  1575 -YAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPML---VAGLLTQEQLSAIFL 1635
             :..|..|:|     .::|.:.|::.||..|.|.|::|...|...:|   .:|||.:.:...:|.
  Rat   424 GHEKLTRRQC-----HQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFS 483

  Fly  1636 NTEDLLENNQTL-----------AERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYC 1689
            |..:|...::.|           |.|.|..|..|      |.|     :.|..|..:...:..||
  Rat   484 NIPELARLHRGLWSSVMVPVLEKARRTRALLQPS------DFL-----KGFKMFGSLFKPYIRYC 537

  Fly  1690 VRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTP 1754
            :.:.|....:.:|.::.:|.|.::..:: ::...:|:.|:..|..|.||:|||||||..:.:.|
  Rat   538 MEEEGCMEYMRSLLRDNDLFRAYVTWAE-KHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKT- 600

  Fly  1755 SHLEGRELLKQAQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDV 1819
            .....:|.:......:|..::|:|       |.:.:|    ...:|.:..:..|:      |.:|
  Rat   601 DEPRAKEAIITMISSVERFIHHVN-------TCMRQR----QERQRLAGVVSRID------AYEV 648

  Fly  1820 LEWNHDEV-RFAMEG-RLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLN- 1881
            :|.::||| :|..|. .|..|.|.... ....|.:|....:|.:..||.|           |::
  Rat   649 VEGSNDEVDKFLKEFLHLDLTAPMPGT-SPEETRQLLLEGSLRMKEGKDS-----------KMDV 701

  Fly  1882 ----FPKHTGIREASLLLVK---EKCGRYTLIREPLYLDRCVVCSEADWDDYFEVQEI----SSK 1935
                |        ..||||.   :|..|..:||.||.:|: :||.|......|.:..:    |:.
  Rat   702 YCFLF--------TDLLLVTKAVKKAERTKVIRPPLLVDK-IVCRELRDPGSFLLIHLNEFHSAV 757

  Fly  1936 DTFIFKAEDGVRTKQWYTQLQYHAQ 1960
            ..:.|:|......:.|...| |:||
  Rat   758 GAYTFQASSQALCRSWVDTL-YNAQ 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	48/199 (24%)
Plekhg5	XP_038965663.1	RBD_PLEKHG5	172..246	CDD:340588	15/93 (16%)
		RhoGEF	438..624	CDD:214619	48/198 (24%)
		PH_PLEKHG5_G6	681..779	CDD:270064	27/118 (23%)
		Atrophin-1	913..>1077	CDD:397323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810