DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and Fgd2

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_038954639.1	Gene:	Fgd2 / 309653	RGDID:	1309840	Length:	707	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	99/552 - (17%)
Similarity:	163/552 - (29%)	Gaps:	193/552 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1333 QSCSSELTASGILE--EDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEH----------STH 1385
            |:|:.:.:...::.  |:|.:.......:||.|:...:......|....:.|          ..|
  Rat     3 QACAKQDSVCNLVAVFENSRASFTSGVEQLDPASPGAWLDSFYSAPGTALGHGLPWTTTPDVGDH 67

  Fly  1386 MDQTLG-----TDSEHHYESIRHSGDPIYEEIHEVP-PPLPLSAPPLNDAELEKKAARSIFEGAS 1444
            ..|:.|     ....|.:|...||.:      |::| .|.|..|||..:      |..|.|...|
  Rat    68 HTQSAGGSPGAAPGPHSFEDQPHSPE------HQLPLSPEPWEAPPAGE------ALTSEFRPVS 120

  Fly  1445 KYDILSYLVDAKERGLAREESFDYGNNPKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLS 1509
            :    :||...|
  Rat   121 R----TYLNSLK----------------------------------------------------- 128

  Fly  1510 PPPHNFICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGIL 1574
                |.:..||.:.|.    :..:..|.||.:.
  Rat   129 ----NKLSSGAWRKSC----QPGASPGPETQEP-------------------------------- 153

  Fly  1575 YAPLVCRKCGKKRVERKEIITEIVETEEKYGRDL----QIILEEFCHPMLVAGLLTQEQLSAIFL 1635
                          |.|.::.|::|||:.|...|    |:..:|.......:....::.:..||.
  Rat   154 --------------EEKRVVQELLETEQAYVARLHLLDQVFFQELLREASRSKAFPEDVVKLIFS 204

  Fly  1636 NTEDLLENNQT--LAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLL 1698
            |...:...:..  |.|..|        :.||...|..||.:.......|..:..|
  Rat   205 NISSIYRFHAQFFLPELQR--------RVDDWTATPRIGDVIQKLAPFLKMYSEY---------- 251

  Fly  1699 LANLEKEKELLRIFLKVSQMENAVLRR---------MNLNSFLMVPVQRVTKYPLLLARLYKVTP 1754
            :.|.|:..|||..::..||....|:.|         :.|...::.||||:.:|.|||....:..|
  Rat   252 VKNFERAAELLATWMDKSQPFQEVVTRIQRSEASGSLTLQHHMLEPVQRIPRYELLLKEYVQKLP 316

  Fly  1755 SHLEGRELLKQAQEKIELHLNHIN---------QEAKDVPTKLWRRISSSSPNRRASCEIDMINI 1810
            :.....|..::|.:.|.....|.|         |...||..:|........|:.....|..::.|
  Rat   317 AQAPDLEDAQRALDMIFSAAQHSNAAIAEMERLQGLWDVYQRLGLEDDIVDPSNTLLREGPVLKI 381

  Fly  1811 KLRKMAIDVLEWNHDEVRFAM--EGRLLYTQP 1840
            ..|:.  |.:|      |:.:  ...|||..|
  Rat   382 SFRRS--DPME------RYLVLFNNMLLYCVP 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	45/209 (22%)
Fgd2	XP_038954639.1	RhoGEF	156..340	CDD:238091	45/201 (22%)
		PH1_FGD2	372..479	CDD:275421	10/42 (24%)
		FYVE_FGD1_2_4	505..569	CDD:277280
		PH2_FGD1-4	591..692	CDD:270056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810