DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF64C and Net1

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_006254268.1	Gene:	Net1 / 307098	RGDID:	1305034	Length:	595	Species:	Rattus norvegicus

Alignment Length:	439	Identity:	104/439 - (23%)
Similarity:	196/439 - (44%)	Gaps:	84/439 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1455 AKER-GLAREESF---------DYGNNPKIIE-EEAADTLSDLDKRQAEERERDRDSGQ-SSMSS 1507
            |.|| .|.|..||         |:....|..| ::...:||.||.::...: |.|..|: :|:::
  Rat    40 ANERCSLRRGSSFTFLTPGPHWDFTLKRKRREKDDDVVSLSSLDLKEPSNK-RVRPLGRVTSLAN 103

  Fly  1508 LSPPPHNFICGGAGKSSGSDVE----RQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQV 1568
            |..|..|    ||.:..|..::    |.|....:.|.|:.......|||...........:::.:
  Rat   104 LISPVRN----GAVRRFGQTIQSFTLRGDHRSPASTQKSFSRATVPTPTKRRSSALWSEMLDISM 164

  Fly  1569 GDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAI 1633
            .::      |..|:     ::|:|.|.|:...|:....||::..:.:..|||...::::|:|:.|
  Rat   165 KES------LTTRE-----IKRQEAIYELSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHI 218

  Fly  1634 FLNTEDLLENNQTLAERMRDAL--DMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGAS 1696
            |.:.:..:..::.|..|:.:|.  |.::||         ||.|.:::...|:|:..||..|..|.
  Rat   219 FGDLDAYIPLHEDLLARIGEATKPDGTVEQ---------IGHILVNWLPGLNAYRGYCSNQLAAK 274

  Fly  1697 LLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTP-SHLEGR 1760
            .|| :.:|:...::.||: ..:|:...|:::|.|||.:|..|:.||||||..:.:.|| .||:.:
  Rat   275 ALL-DQKKQDPRVQDFLQ-RCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHTPKDHLDVQ 337

  Fly  1761 EL---------------LKQAQEKIELH---LNHINQEAKDVPTKLWRRISSSSPNRRASCEIDM 1807
            .|               ||:.:.:.:.:   |.:::::.||      .||.:|   :...|..::
  Rat   338 LLEKAILIIQEVLSDINLKKGESECQYYIDKLEYLDEKQKD------PRIEAS---KVLLCHGEL 393

  Fly  1808 INIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPV 1856
            .|....|:.|           |..:..|:.|:|...|.:.:..:...|:
  Rat   394 KNKSGHKLYI-----------FLFQDILVLTRPVTRNERHSYQVYRQPI 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	54/206 (26%)
Net1	XP_006254268.1	RhoGEF	178..354	CDD:214619	51/186 (27%)
		PH_Net1	368..502	CDD:270044	16/84 (19%)
		PH	387..501	CDD:278594	10/56 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810