DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and Akap13

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_038961459.1	Gene:	Akap13 / 293024	RGDID:	727893	Length:	2793	Species:	Rattus norvegicus

Alignment Length:	2432	Identity:	448/2432 - (18%)
Similarity:	766/2432 - (31%)	Gaps:	804/2432 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SWSQRLKTLGSGD-SVDKNASLAAVSGMQAMQQLQLHMQQQHQQLQQHQQQLQQQQQQ------Q 65
            |||.....:..|| ||..:..|...:   ...:.:.|.:........|..:|...|||      :
  Rat   229 SWSSLSYEIPYGDYSVRHHRELDIYT---LTSESESHCEPHGDSCTGHISKLMNIQQQLMKTNLK 290

  Fly    66 QQQQHMAHHGHPQMLTAYQLPPVPAA------EFLPSALSRS---------MKYAEPWIYGTV-- 113
            |....|     |.|:|......||..      :.||...::|         .|.|.|....:|
  Rat   291 QMDNLM-----PLMVTTQDSSCVPCVPEPSDHQQLPFEETKSTVCCQGSPGRKDASPCDLSSVVE 350

  Fly   114 ----------RGIPARPSYGYHPHAAAIFAAT-------------------EGVP---------G 140
                      .....||..|..| |:|:.:.:                   ||:|         |
  Rat   351 EENLICSHKKNKDTGRPGEGVEP-ASAVDSRSASHQDSCLQSIPDCGVKGREGLPSCGNRNEVTG 414

  Fly   141 TTALAVVIC--------SCAEYLNGTKRDVKKASVCKKCKGSRLPLATIGGTGGTVRLPAVSG-- 195
            |....|..|        |..:.:..|:.|.::.|     .|..||.::....|.    |..:|
  Rat   415 TQYSGVATCQQPLSSESSVPQDVLVTEPDARQHS-----SGRELPDSSSTDAGA----PEKAGEL 470

  Fly   196 SSSSRRPMAATMRVVSATKKSRPSILDPQKDPYDLMRRTRLLSPEPSSKEADSKSRSRSETVANQ 260
            ..|...|.|       .|:.|:|.:.:..|:        ||.:.:.||.||.:....|      :
  Rat   471 EHSLLTPDA-------TTQNSKPQVGESAKE--------RLENSDISSAEATAVQALR------E 514

  Fly   261 PRGRT-------RTRAPPPPAPIQKSPAVA---VPTAVPDPTDCWLMEDNESLLQSSGLASRANS 315
            |:.:.       ..||....||.:.|||.:   :||..|.      ||..|...: .|:.|..:|
  Rat   515 PKQKADVTNHVFAARAAGADAPAEASPAWSPEEIPTGKPG------METQERGCE-GGITSDQSS 572

  Fly   316 RRSILRCHVNPYDLISSENGKLHSNLR---------KPNDHFDVADAQLNDDELGERKSKGTSKF 371
            :       |.|....::|| |:...|.         :.....|:..:....|.:.::.|:.:::.
  Rat   573 Q-------VLPAAAAATEN-KVLDGLELETLPACPCETASSLDLTVSGPRPDGMPKQNSESSAQH 629

  Fly   372 -----YSGNVAAIAGQRISLGDKSGDSSDPGDSYERIIMVSGGESTASNGPRRPPRNKKADEPAE 431
                 ....:.:|||    .|..|.:|:.| .|.|    .|.|.|...:|      :.:|..|..
  Rat   630 AQSLNSQAPLCSIAG----AGTPSAESACP-QSTE----TSSGGSVIEHG------SGEASLPES 679

  Fly   432 MPAAAGAAGAAGAAATSPPAA-AVTAATAV--------------------------KPKAVTLAK 469
            ..|.....|...|.....|.| .||:.||.                          .|...||..
  Rat   680 TAAQPEPQGLCTAPCPEDPQADTVTSDTAAHNQKSVGSCHLCALDAKNQEKDLRQDTPSVNTLED 744

  Fly   470 V-----------EKIEKDNES---AYTVLTVTPTSPAI--KSILKRPTTLELPGVGMSPLPLPPV 518
            |           ||:|.|..|   :...|..:|.|.::  ..:|...::.:..|.....|...|.
  Rat   745 VPHLPSVVPQSEEKLEPDQVSPRGSSFSLASSPESESVTKDDVLSLVSSQKEKGTATPQLHRAPA 809

  Fly   519 NNSGLVTPAGKSQFYIPTPTGTAATPTSSSTPMATSTPTPNA----SITATTAAAGAAITPGSRK 579
            .:.|              |.|.....|......|.|.|||:|    :....|:..|.....||..
  Rat   810 CSDG--------------PDGRDLNDTDKVGDGAASPPTPSAVELQTSMGNTSPVGVGEQEGSSL 860

  Fly   580 KVQF-MVEDKIIATTATAATTDDS-----DASAVATKTNYEYYNRKRNAATATAAAATAASAAAA 638
            .... ::.|.::.:...||...||     ..|.|..:::.......::.||...:......::..
  Rat   861 TATLEVLSDSLLQSVDKAALVSDSLLPEEGGSIVVPESSTALGQGGKDKATKCPSVKEDVHSSEM 925

  Fly   639 SPPTAATSTDQQE---------ATLFAADIDDEHNFTTSGEAAPPFIKPDSLHYEDVLP--GPQI 692
            |.....|....||         :.|.|.:...:|  :.|.:.....::.::.|.::|.|  .|.:
  Rat   926 SREDQRTPPPGQEISRLCEKPMSALCAGEKALQH--SNSPDTPSACLQTETKHNKEVAPQSSPLM 988

  Fly   693 FDSSESS---AKLSLPADGSPHVTT---SPVSVLPTGTSNGV--GGAGLGPGPAGVSGEEAPATA 749
            ...:..:   .|.||.||.....::   |..|:||.|.|..:  ....|......:..:...:..
  Rat   989 KGGAVQNLVPPKTSLSADSEQKTSSTEQSGSSLLPGGASEALRCSQPSLSVSVESIQFQGKTSAC 1053

  Fly   750 AATAAATQKTTAAN------RDYDDDDEHNDKDESH-----------------DNKPNDLAE--- 788
            ..:..|.:..|.|:      ....:|..|:.||.|.                 |....||.|
  Rat  1054 KVSRNAMEDVTVADAFLATAEPTKEDALHHVKDISDLLNQEKKTTPGLPEALLDKGVTDLQEVIT 1118

  Fly   789 ---REQDREGDKEQGRAGELGISRQEKKDAGGKPAASQKRAAQTTQSRNPIRRAHSERHLS---- 846
               ...|.:.:|.:|.  :|.....:.|:....        .:|||.  |.|...:|..||
  Rat  1119 PEIEPLDCKREKLEGT--DLSCPTSKSKETPNN--------EETTQP--PARDLPTETGLSAIND 1171

  Fly   847 TAPLAAHGHASSACAAGRNCH-----SIPMTPPASGP------QNVILNFKDTMALRIKSNRSDS 900
            ..|.|...|.:.|...|...:     .:..|..|.||      :.......:.:..:||::.:
  Rat  1172 NGPQADMKHVTQASVPGEESNVTTVLGMVSTQAADGPPGADSIEETATRIVEAVIKQIKASNT-- 1234

  Fly   901 RDLFQRRPTEPPPPPPPKGAGKGLEP---------LPHEINKSPLSPQRTVVRVAPFKPQQQQVG 956
                .|...|...||......|.:|.         ||.|    ||..:.|         |::..|
  Rat  1235 ----LRTQVEIQNPPLSSSEIKEIENTGSESARVFLPGE----PLQMENT---------QKETTG 1282

  Fly   957 ------GSGDGFTHEVHRLKISHSEEDADLGVE---LRRRPNLFLSSPGEEDAAPKKTSILISGD 1012
                  .:.:.....|||.:.:....|...|.|   |.:|     |:..||:|
  Rat  1283 HCSVETEAPEKIILAVHRPEPAPEMPDTKTGGEVDLLSKR-----SAASEEEA------------ 1330

  Fly  1013 DCYSTMNLSANAAQPLYQ---SSVVVNSHS--ATSVCISVSS--AEEQEQELNQLNTLRSQQMGM 1070
                   :...||.|..:   .:.|:|..|  |...|...:|  |.:|..|....     ..:|:
  Rat  1331 -------IGNGAATPKMKQAPGTQVINRESWCAIEPCPEAASLLASKQSSECRSF-----IDVGL 1383

  Fly  1071 GI------AIIPIRGASEVNLQRSVS-----------------CISSTSSSSTSSSSSSSGRGRT 1112
            |.      .::.....|:.:|..|.|                 |.::.|||||..::|
  Rat  1384 GTECATKEGVLQRESGSDSDLFHSPSDEMDSIIFSKPEEEQLLCDTTGSSSSTDDTAS------- 1441

  Fly  1113 LIRLDYDRERKGSATSSTPINTPPVISSTPATPPPTDLPIENANPLVPHETELLKILRNPVEAVK 1177
                 .||.....:..|.|                              :|..|...||  ....
  Rat  1442 -----LDRHSSHGSDVSLP------------------------------QTSKLNRSRN--HQSS 1469

  Fly  1178 LNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETETVAEL-- 1240
            .....|  |:...:||.       |.|.:|:                 |::.|. |.:::.|:
  Rat  1470 NGFFSH--GVDPESREG-------ESEPAGS-----------------GEMEEE-EMDSITEVPA 1507

  Fly  1241 ----IENSLQRLQQARR---GIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLS 1298
                :.||::.|...||   |...:...| .:||:..|..:....:.|.|.
  Rat  1508 NRSFLRNSMRSLSPFRRHSWGPGKNAASD-AEMNQRSSMQVLGHVVRRPPI-------------- 1557

  Fly  1299 NRGSIS---SANSFASAHNYEL----FDFDG--GAGG--------------NESDCYQSCSSELT 1340
            :|.|:|   |...:::|.|.:.    |..:|  |.||              |.|:.....|.|..
  Rat  1558 HRRSMSWCPSGVQYSAALNADFNIRSFSLEGLTGGGGVGNKPSSSLEISSANSSELRNPFSGEEQ 1622

  Fly  1341 ASGI--LEEDSVSP--------------IKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQT 1389
            .|.:  |.|:.:.|              .:..:...:..|.|....|....:|..|.|.
  Rat  1623 RSSLMSLSEEHLEPDQRQHHRMFDQQTCYRSKQQGFNYCTSAISSPLTKSISLMTISHP------ 1681

  Fly  1390 LGTDSEHHYESI-RHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLV 1453
             |.|:...:.|. .:..:.|.||.....||.|           .||:    ||
  Rat  1682 -GLDNSRPFHSASANLTESITEENCNFLPPSP-----------SKKS----FE------------ 1718

  Fly  1454 DAKERGLAREESFDYGNNPKIIEEEAADTLSDLDK---RQAEERERDRDSGQSSMSSLSPPP--- 1512
              ::.|.....:|.|..|.....:::.:...:.||   ::.|.:|:::|....:..:.||.|
  Rat  1719 --EKSGTKVSRTFSYIRNKMSSSKKSKEKEKEKDKTKEKEKESKEKEKDKKTLNGHTFSPIPIVG 1781

  Fly  1513 --------------HNFICGGAG----------------------------------------KS 1523
                          ..:.|...|                                        ..
  Rat  1782 PINCSQCMKPFTNKDAYTCASCGAFVHKGCRENLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNK 1846

  Fly  1524 SGSDVERQDS-----------------------------------GVGSETSKTSRSKY--QATP 1551
            |....||..|                                   |||::.:.::..|:  .:|.
  Rat  1847 SSQPKERPRSAVLLAEEAIAAPMFTNRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTD 1911

  Fly  1552 TVLHLC---EDCDGAVEMQVG--------------DNGILYAPLVCRKCGKK--------RVERK 1591
            ::..:|   |..:...:..||              |:..|.|....|....|        .|:|:
  Rat  1912 SLNKICKVNESTESLTDEGVGTDMNEGQLMGDFESDSKQLEAESWSRTVDSKFLKQQKKDVVKRQ 1976

  Fly  1592 EIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENN----QTLAERMR 1652
            |:|.|:::||..:.|.|:|:.:.:...|:...|..|:.:..:|...::|:..:    |.:.||.:
  Rat  1977 EVIYELMQTELHHIRTLKIMSDVYSRGMMTDLLFEQQMVEKLFPCLDELISIHSQFFQRILERKK 2041

  Fly  1653 DALDMSLEQGDDDLLTVNIGRIFL------DFTQMLHAFESYCVRQAGASLLLANLEKEKELLRI 1711
            ::|   :::.:.:.|...||.:.:      :..::...:..:|.:...:.....:|..:.:..:.
  Rat  2042 ESL---VDKSEKNFLIKRIGDVLVSQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYTKDKRFQA 2103

  Fly  1712 FLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNH 1776
            |:| .:|.::|:||:.:...:::..||:||||:|..|:.:.|..                   |.
  Rat  2104 FVK-KKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKD-------------------NE 2148

  Fly  1777 INQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPT 1841
            :.||.......|.:.:..:..::.||.|                    .:||...    :||: |
  Rat  2149 VEQEDLTQSLSLVKDVIGAVDSKVASYE--------------------KKVRLGE----IYTK-T 2188

  Fly  1842 DSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLNFPKHTGIREASLLLVKEKCGRYTLI 1906
            ||.               .:...|....:..|....:||       :|:.|:.| |...||...:
  Rat  2189 DSK---------------SIMRMKSGQMFAKEDLRRKKL-------VRDGSVFL-KSATGRLKEV 2230

  Fly  1907 REPLYLDRCVVCSEADWDDYFE---------------VQEISSKDTFIFKAEDGVRTKQWYTQLQ 1956
            :..|..|..|...|.|....|.               |:|::.::..:|....||:..:   .::
  Rat  2231 QAVLLTDILVFLQEKDQKYVFASLDHKSTVISLKKLIVREVAHEEKGLFLISMGVKDPE---MVE 2292

  Fly  1957 YHAQGMGAWRKRRNALANIM---INGM 1980
            .||..    |:.||:...|:   ||.:
  Rat  2293 VHASS----REERNSWIQIIQDTINSL 2315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	37/195 (19%)
Akap13	XP_038961459.1	PHA03307	545..>837	CDD:223039	67/335 (20%)
		C1_AKAP13	1769..1824	CDD:410428	5/54 (9%)
		RhoGEF	1975..2169	CDD:238091	42/216 (19%)
		PH_AKAP13	2212..2314	CDD:275427	25/116 (22%)
		SMC_prok_B	<2509..>2669	CDD:274008
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810