Protein Alignment RhoGEF64C and Arhgef15

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_008766014.1
• Gene: Arhgef15 / 287418
• RGDID: 1306961
• Length: 850
• Species: Rattus norvegicus
• Alignment Length: 924
• Identity: 177/924 - (19%)
• Similarity: 317/924 - (34%)
• Gaps: 301/924 - (32%)

  Fly  1125 SATSSTPINTPPVISS--TPATPPPT------------DLPIENANPLVPHETELLKILRNPVEA 1175
            ||:..|.|...|...|  .||..||:            |.|....:|             :||..
  Rat    54 SASVCTSIFWEPPTGSLKPPALLPPSVSRASLDSQTSPDSPSSTPSP-------------SPVSR 105

  Fly  1176 VKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKD-----PGFIAKLLQDPMLGQVAEGLETE 1235
            ..::..|..|....|.:.||.|:  ....:...|::|     ||.:.:|     .|:...|.|.:
  Rat   106 RSISPEPAPCSPVPPPKPSGSSR--TPLPLGPVPLQDGSASAPGTVRRL-----AGKFEWGAEGK 163

  Fly  1236 TVAELIENSLQRLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLSNR 1300
            ..:   .:||:|..|.  ..|::|.|:          :||          .|:|
  Rat   164 AQS---ADSLERCSQG--STDVNGEKE----------TLQ----------VGLS----------- 192

  Fly  1301 GSISSANSFASAHNYELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPETELDAATR 1365
            |:.|..|....|           |......|  .|...:...|:  |....|:...:..|.|..|
  Rat   193 GNGSQENGTPDA-----------ALACPPCC--PCVCHVAKPGL--ELRWVPVGSSDDILRAPCR 242

  Fly  1366 AKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAE 1430
            |                                       .|:......:.||: :|.||:
  Rat   243 A---------------------------------------SPLRASRSRINPPV-ISHPPV---- 263

  Fly  1431 LEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNNPK-IIEEEAADTLSDLDKRQAEER 1494
                 ..:.:...::..:|..|...|...: |:::...|..|: .:|..:.|.:....|  |.|.
  Rat   264 -----VLTSYRSTAERKLLPPLKPPKPTRV-RQDTSTSGELPQPDLELPSEDGIQAAPK--AWEG 320

  Fly  1495 ERDRDSGQSSMSSLSPPPHNFICGGAGKSSGS--------DVERQDS----------------GV 1535
            :|..::.|:     :|||   :.....:..|.        ::..||.                ||
  Rat   321 DRPEEAPQN-----APPP---VALEGREEEGLEGLKELQWELPLQDEPLYQTYRAAVLSEELWGV 377

  Fly  1536 GSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPL-VCRKCG--------KKRVERK 1591
            |.:...:..:..:| ||...|           .|....|:..| ..|..|        ::|::
  Rat   378 GEDGGPSPANPGEA-PTFSRL-----------PGPRNTLWQELPAVRGSGLLESLSPQERRMQ-- 428

  Fly  1592 EIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQ----TLAERMR 1652
            |.:.|:|.:|..|.|.|:::.:.|.....:...||......:|.|.:.:...::    ||..|:|
  Rat   429 ESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQSVSERFLGTLLSRVR 493

  Fly  1653 DALDMSLEQGDDDLLTV----NIG--RIFLDFTQ-MLHAFESYCVRQAGASLLLANLEKEKELLR 1710
            .:..:|      ||..|    .:|  .:::|:.: ..:..|:|      :.|:..|:....||.|
  Rat   494 SSPHIS------DLCDVVHAHAVGPFSVYVDYVRNQQYQEETY------SRLMDTNVRFSAELRR 546

  Fly  1711 IFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLN 1775
            : ..:.:.|     |:.|.|||::|.||:|:..:||             :.:|.|.:|......|
  Rat   547 L-QSLPKCE-----RLPLPSFLLLPFQRITRLRMLL-------------QNILSQTEEGSSRQEN 592

  Fly  1776 HINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLR---KMAIDVLEWNHDEVRFAMEGRLLY 1837
              .|:|....:|:..|.|:.....:.:.|:..:..:||   ..|:.::.|:.   |..::|.|
  Rat   593 --AQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSR---RLELQGEL-- 650

  Fly  1838 TQPTDSNWKKARTI-----KLTPV------NALLVTNGKPSANYR------AEKAMSEKLNFPKH 1885
               |:...::...:     :.||:      :.||:|  :|.:..|      |.:::.:....|..
  Rat   651 ---TELGCRRGGVLFTSRPRFTPLCLLLFSDLLLIT--QPKSGQRLQVLDYAHRSLVQAQQVPDP 710

  Fly  1886 TGIREASLLLVKEKCGRYT--LIR------------------------EPLYLD-RC--VVCSEA 1921
            :|.....|.|:....||.|  |::                        :.:|.| .|  .:|||.
  Rat   711 SGPPTFRLSLLSNHQGRPTHRLLQAASLSDMQRWLGAFPTPGPLPCSPDTIYEDCECSQELCSEP 775

  Fly  1922 DWDDYFEVQEISSK 1935
            ......|.|.:.||
  Rat   776 STPSKTEGQSLESK 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	44/196 (22%)
Arhgef15	XP_008766014.1	RhoGEF	431..607	CDD:279015	47/208 (23%)
		PH_ephexin	631..751	CDD:269929	22/129 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900