Protein Alignment RhoGEF64C and ARHGEF16

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_016856538.1
• Gene: ARHGEF16 / 27237
• HGNCID: 15515
• Length: 726
• Species: Homo sapiens
• Alignment Length: 655
• Identity: 141/655 - (21%)
• Similarity: 218/655 - (33%)
• Gaps: 184/655 - (28%)

  Fly  1413 HEVPPPLPLSAPPLNDAELEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNNPKIIEE 1477
            ||.|.|:.||.        |..||..:  |..:....|..|.:|.:..||.:||    ...::..
Human    82 HEEPWPIVLST--------ESPAALKL--GTQQLIPKSLAVASKAKTPARHQSF----GAAVLSR 132

  Fly  1478 EAAD-----------TLSDLDKRQAEERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVERQ 1531
            |||.           :|.|:|.        |:|.|.....:|....:.....|.||..|.....|
Human   133 EAARRDPKLLPAPSFSLDDMDV--------DKDPGGMLRRNLRNQSYRAAMKGLGKPGGQGDAIQ 189

  Fly  1532 DS----GVGSETS-----------KT------SRSKYQATPTVLHLCEDCDGAVEMQVGDNGIL- 1574
            .|    .:..|.|           ||      .:..::..|.:....:: .|....|..|:.||
Human   190 LSPKLQALAEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQEIQE-RGLNTSQESDDDILD 253

  Fly  1575 -------------------YAPL--------------VCRKCGKKRVERKEIITEIVETEEKYGR 1606
                               |.|.              :..:...:..:|:|.:.||:.:|..|..
Human   254 ESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQH 318

  Fly  1607 DLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDD-DLLTVN 1670
            .|.|::|||.....:...:||.:...:|.|..|:|..:|...|        .|||... .:|..:
Human   319 SLSILVEEFLQSKELRATVTQMEHHHLFSNILDVLGASQRFFE--------DLEQRHKAQVLVED 375

  Fly  1671 IGRIFLDFTQM-LHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRR-----MNLN 1729
            |..|..:..:. .|.:.:||..:......|..|.......|..|:      .:.||     :.:.
Human   376 ISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLISSNAAFREALR------EIERRPACGGLPML 434

  Fly  1730 SFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVPTKLWRRISS 1794
            |||::|:||||:.|||:..|...|..|.|..:...:|.:.|...:...|:.|        .|:..
Human   435 SFLILPMQRVTRLPLLMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGA--------HRMER 491

  Fly  1795 SSPNRRASCEIDMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPV--- 1856
            .........::|...:|...: |....|      ....|.|...:.|.    ..|.|...|.
Human   492 MEQMYTLHTQLDFSKVKSLPL-ISASRW------LLKRGELFLVEETG----LFRKIASRPTCYL 545

  Fly  1857 ----NALLVTNGKPSANY-----------RAEKAMSEKLNFPKHTGIREAS------LLLVKEKC 1900
                :.|:||..|...:|           :.||....:|..| ..|.|.:|      :.|::...
Human   546 FLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSELPLP-GGGNRSSSVPHPFQVTLLRNSE 609

  Fly  1901 GRYTLIREPLYLD--------RCVVC---SEADWDDYFEVQEISSK---------DTFIFKAEDG 1945
            ||    :|.|.|.        |.:|.   ||..|      |.:|||         ..|..|..|.
Human   610 GR----QEQLLLSSDSASDRARWIVALTHSERQW------QGLSSKGDLPQVEITKAFFAKQADE 664

  Fly  1946 VRTKQ 1950
            |..:|
Human   665 VTLQQ 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	49/192 (26%)
ARHGEF16	XP_016856538.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840