Protein Alignment RhoGEF64C and Plekhg5

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_006538986.1
• Gene: Plekhg5 / 269608
• MGIID: 2652860
• Length: 1103
• Species: Mus musculus
• Alignment Length: 933
• Identity: 187/933 - (20%)
• Similarity: 310/933 - (33%)
• Gaps: 301/933 - (32%)

  Fly  1092 ISSTSSSSTSSSSSSSGRGRTLIRLDYDRERKGS------ATSSTPINTPPVISSTPATPPPTDL 1150
            :..|..|...|:....|..|      :|...:||      :|.|.|          |.|.|..||
Mouse    88 LCETCDSKFHSTLHYDGHVR------FDLPPQGSVLARNVSTRSCP----------PRTSPAADL 136

  Fly  1151 PIENANPLVPHETELLKILRNPVEAVKLNLVPHVCGLRAPTRESGKSK----KIQEEEVSGTPVK 1211
            ..|...                            |     |...|..|    ||.:::.......
Mouse   137 EEEEEG----------------------------C-----TDGKGDRKSAGLKISKKKARRRHTD 168

  Fly  1212 DPG---FIAKLLQDPMLGQVAEGLETETVAELIENSLQRLQQ---ARRGIDMSGTKDH-DDMNRL 1269
            ||.   |..|.       .:...:|||.|..:.:.||..:..   .|:||.:.....: |..|..
Mouse   169 DPSKECFTLKF-------DLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTP 226

  Fly  1270 ISASLQRIRLE----RQPATPGISATKEEDRLSNRGSISSANSFASAHNYELFDFDGGAGGNESD 1330
            :|.:.:..|..    |..|.||     :|.::......|.:.|..:..       ..|||...|
Mouse   227 LSLTFEAYRFGGHYLRVKAKPG-----DEGKVEQGVKDSKSLSLPALR-------PSGAGPPVS- 278

  Fly  1331 CYQSCSSELTASGILEEDSVSPIKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSE 1395
                             :.|.|....|:.||              .||......:|.:.||
Mouse   279 -----------------ERVDPQSRRESSLD--------------ILAPGRRRKNMSEFLG---- 308

  Fly  1396 HHYESIRHSGDPIYEEIHEVPPPLPLSAP---------PLNDAELEKKAAR--SIFEGASKYDIL 1449
                   .:|.|    .||.|.|...|.|         .:|::...:.|:|  ..|..:......
Mouse   309 -------EAGIP----GHEPPAPSSCSLPVGSSGGTSSGINESWKNRAASRFSGFFSSSPSTSAF 362

  Fly  1450 SYLVDAKERGLAREESFDYGNNPKIIEEEAADTLSDLDKRQAEERERDRDSGQSSMSSLSPPPHN 1514
            |..||..|:..::..::.....|::...    ...|.|..:.||.:.:.|.
Mouse   363 SREVDKMEQLESKLHAYSLFGLPRMPRR----LRFDHDSWEEEEEDDEEDE-------------- 409

  Fly  1515 FICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLV 1579
                   :|||..:|                               |...|:..|     :..|.
Mouse   410 -------ESSGLRLE-------------------------------DSWRELTDG-----HEKLT 431

  Fly  1580 CRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPML---VAGLLTQEQLSAIFLNTEDLL 1641
            .|:|     .::|.:.|::.||..|.|.|::|...|...:|   .:|||.:.:...:|.|..::.
Mouse   432 RRQC-----HQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPEIA 491

  Fly  1642 ENNQTL-----------AERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGA 1695
            :.::.|           |.|.|..|..|      |.|     :.|..|..:...:..||:.:.|.
Mouse   492 KLHRGLWGSVMVPVLEKARRTRALLQPS------DFL-----KGFKMFGSLFKPYIRYCMEEEGC 545

  Fly  1696 SLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGR 1760
            ...:..|.::.:|.|.::..:: ::...:|:.|:..|..|.||:|||||||..:.:.|... ..:
Mouse   546 MEYMRGLLRDNDLFRAYVTWAE-KHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTDDP-RTK 608

  Fly  1761 ELLKQAQEKIELHLNHIN------QEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAIDV 1819
            |.:......:|..::|:|      ||.:.: ..:..||.:......::.|:|    ||.|
Mouse   609 EAIVTMISSVERFIHHVNTCMRQRQERQRL-AGVVSRIDAYEVVEGSNDEVD----KLLK----- 663

  Fly  1820 LEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKLN--- 1881
             |:.|.::...|.|    |.|.:       |.:|....:|.:..||.|           |::
Mouse   664 -EFLHLDLTAPMPG----TSPEE-------TRQLLLEGSLRMKEGKDS-----------KMDVYC 705

  Fly  1882 --FPKHTGIREASLLLVK---EKCGRYTLIREPLYLDRCVVCSEADWDDYFEVQEI----SSKDT 1937
              |        ..||||.   :|..|..:||.||.:|: :||.|......|.:..:    |:...
Mouse   706 FLF--------TDLLLVTKAVKKAERTKVIRPPLLVDK-IVCRELRDPGSFLLIYLNEFHSAVGA 761

  Fly  1938 FIFKAEDGVRTKQWYTQLQYHAQ 1960
            :.|:|......:.|...: |:||
Mouse   762 YTFQASSQALCRSWVDTI-YNAQ 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	48/205 (23%)
Plekhg5	XP_006538986.1	RBD_PLEKHG5	172..246	CDD:340588	16/80 (20%)
		RhoGEF	440..626	CDD:214619	47/198 (24%)
		PH_PLEKHG5_G6	683..781	CDD:270064	26/118 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910