DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF64C and ARHGEF26

DIOPT Version :9

Sequence 1:NP_001261425.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_001238891.1 Gene:ARHGEF26 / 26084 HGNCID:24490 Length:871 Species:Homo sapiens


Alignment Length:1025 Identity:185/1025 - (18%)
Similarity:347/1025 - (33%) Gaps:320/1025 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1013 DCYSTMNLSANAAQPLYQSSVVVNSHSATSVCISVSSAEEQEQELNQLNTLRSQQMGMGIAIIPI 1077
            |..|.::.|:|:..||::...:...|..      :..::.:.|.....|       |:.|...|:
Human     2 DGESEVDFSSNSITPLWRRRSIPQPHQV------LGRSKPRPQSYQSPN-------GLLITDFPV 53

  Fly  1078 RGASEVNLQRSVSCISSTSSSSTSSSS-----------SSSGRGRTLIRLDYDRERK-------- 1123
            .....:...:..:.:.:.|.|.|...|           ::.|......|....|.|:        
Human    54 EDGGTLLAAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYRAASPRLRRPKSPKLPK 118

  Fly  1124 ----GSATSSTPINTPPVISSTPATPPPTDLPIENAN---PLVPHETELLKILRNPVEAVKLNLV 1181
                ||..|  |.|....:.:.|  |||...|....|   |..|.| :|..:..:||.:      
Human   119 AVPGGSPKS--PANGAVTLPAPP--PPPVLRPPRTPNAPAPCTPEE-DLTGLTASPVPS------ 172

  Fly  1182 PHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETETVAELIENSLQ 1246
            |...||.|.....|...:      ||...|||                                 
Human   173 PTANGLAANNDSPGSGSQ------SGRKAKDP--------------------------------- 198

  Fly  1247 RLQQARRGIDMSGTKDHDDMNRLISASLQRIRLERQPATPGISATKEEDRLSNRGSISSANSFAS 1311
                 .||:.....|         |:|.|::.|:|.|       ::|.:.|.|...:.|.||.|:
Human   199 -----ERGLFPGPQK---------SSSEQKLPLQRLP-------SQENELLENPSVVLSTNSPAA 242

  Fly  1312 AHNYELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPETELDAATRAKFYQLLVDAT 1376
            .           ..|.:....:|.:||:..|           |.....::...|....:.:|:..
Human   243 L-----------KVGKQQIIPKSLASEIKIS-----------KSNNQNVEPHKRLLKVRSMVEGL 285

  Fly  1377 LAEIEHS---THMDQTL--------GTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAE 1430
            ...:.|:   :.:|..:        |..|..:..::....|  ::.        |.|:...|  .
Human   286 GGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFD--FDS--------PTSSKKKN--R 338

  Fly  1431 LEKKAARSIFEGASKYDILSYLVDAKERGLAREESFDYGNNPKIIE---EEAADTLSDLDKRQAE 1492
            :.:...:.:.|...|:..|..:   |::.|..:.:||...|..:.:   |:|.|..||   .::|
Human   339 MSQPVLKVVMEDKEKFSSLGRI---KKKMLKGQGTFDGEENAVLYQNYKEKALDIDSD---EESE 397

  Fly  1493 ERERDRDSG--------QSSMSSLSPPPHNFICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQA 1549
            .:|:..|..        :|:.|.||.                 |:|:  |:....|:..|     
Human   398 PKEQKSDEKIVIHHKPLRSTWSQLSA-----------------VKRK--GLSQTVSQEER----- 438

  Fly  1550 TPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEE 1614
                                                   :|:|.|.|::.:|..|...|:|::..
Human   439 ---------------------------------------KRQEAIFEVISSEHSYLLSLEILIRM 464

  Fly  1615 FCHPMLVAGLLTQEQLSAIFLNTEDLLENNQ----TLAERMRDAL---DMSLEQGDDDLLTVNIG 1672
            |.:...::..:|:.:...:|.|..|:.|.::    .|..|.::.:   |:|      |::..:..
Human   465 FKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDIS------DIVEKHTA 523

  Fly  1673 RIFLDFTQMLHAFESYCV----RQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLM 1733
            ..|       ..:..||.    :|.....|||.....||:|.   ::...|:.  |.:.:.|||:
Human   524 STF-------DPYVKYCTNEVYQQRTLQKLLATNPSFKEVLS---RIESHEDC--RNLPMISFLI 576

  Fly  1734 VPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEAKDVP-TKLWRRISSSSP 1797
            :|:||||:.|||:..:.:.||......|:.|:|.:::...:...|:.|:.:. |::...|:|   
Human   577 LPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINS--- 638

  Fly  1798 NRRASCEIDMINIKLRKM-AIDVLEW--NHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNAL 1859
                     .:..|::.. .:....|  ...|:...:|..:|:::.|    .|.:.......:.|
Human   639 ---------QLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRT----SKQQVYFFLFNDVL 690

  Fly  1860 LVTNGKPSANYR-----------AEKAMSEKLNFPKHTGIREASLLLVKEKCGR--YTLIREPLY 1911
            ::|..|...:|.           .|...:|:||  ...|...:::|..::....  :||      
Human   691 IITKKKSEESYNVNDYSLRDQLLVESCDNEELN--SSPGKNSSTMLYSRQSSASHLFTL------ 747

  Fly  1912 LDRCVVCSEADWDDYFEVQEISSKDTFIFKAEDGVRTKQWYTQLQYHAQG 1961
               .|:.:.|           :.|...:..||......:|.|.|. |:.|
Human   748 ---TVLSNHA-----------NEKVEMLLGAETQSERARWITALG-HSSG 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_001261425.1 RhoGEF 1593..1779 CDD:279015 45/196 (23%)
ARHGEF26NP_001238891.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..49 10/59 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 86..233 43/217 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..310 2/21 (10%)
RhoGEF 443..622 CDD:279015 45/196 (23%)
PH_ephexin 643..781 CDD:269929 28/164 (17%)
SH3_ARHGEF16_26 793..847 CDD:212871
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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