DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF64C and rgf1

DIOPT Version :9

Sequence 1:	NP_001261425.1	Gene:	RhoGEF64C / 38578	FlyBaseID:	FBgn0035574	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_588116.1	Gene:	rgf1 / 2539580	PomBaseID:	SPCC645.07	Length:	1334	Species:	Schizosaccharomyces pombe

Alignment Length:	1260	Identity:	236/1260 - (18%)
Similarity:	401/1260 - (31%)	Gaps:	398/1260 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   805 LGISRQEK--KDAGGKPAASQKRAAQTTQSRNPIRRAHSERHLSTAPLAAHGHASSACAAGRNCH 867
            ||::...:  ::..|.|           :.|.|.|...:...:..||::..
pombe     9 LGVNESSRAYEEIFGAP-----------RKREPARTVSTPAFMEPAPVSKK-------------- 48

  Fly   868 SIPMTPPASGPQNVILNFKDTMALRIKSNRSDSRDLFQRRPTEPPPPPPPKGAGKGLEPLPHEIN 932
              |:.||........|.|:.|..               :.|:..||.||           .|:..
pombe    49 --PLPPPTRRLPRKPLPFRSTSL---------------QPPSSQPPAPP-----------THQRE 85

  Fly   933 KSPLSPQRTVVRVAPFKPQQQQVGGSGDGFTHEVHRLKISHSEEDADLGVELRRRPNLFLSSPGE 997
            .||:   :.:.....|    ..|.|:.:  .|::..|.:....:...|...|...|:.    |..
pombe    86 ASPV---KNIEHSESF----PSVFGTSN--NHQIVPLTLKDGNDFGALYASLNTTPHF----PQV 137

  Fly   998 EDAAPKKTSI------LISGDDC----YSTMNLSANAAQPLYQSSVVVNSHSATSVCISVSSAEE 1052
            .:.||..::.      ..||||.    :.....|.::..|: ..||..|..||.|   ||:.:.|
pombe   138 SNHAPNNSNSPSLTWHTSSGDDSNQNPFFVRRQSQSSTSPV-SDSVDENLLSAVS---SVTESVE 198

  Fly  1053 QEQELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSVSCISSTSSSSTSSSSSSSGRGRTLIRLD 1117
            ....|:|.....|          |:|.:..       ..:||.|...|..||.:.|
pombe   199 TNLHLDQNYPYGS----------PVRSSKN-------PFLSSNSRLPTDDSSHTVG--------- 237

  Fly  1118 YDRERKGSATSSTPINTPPVISSTPA-TPPPTDLPIENANPLVPHETELLKILRNPVEAVKLNLV 1181
                 ..|.||.|   .||::||..| |.|....|...| ||:...:|....:..|.::::|
pombe   238 -----SHSFTSGT---HPPIVSSNSAFTLPNAVTPAAQA-PLIRSVSEYPANVSPPAQSLQL--- 290

  Fly  1182 PHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKLLQDPMLGQVAEGLETETVAELIENSLQ 1246
            |......|....|..|....:...||..|              ...|..|..| |:.:
pombe   291 PKSTSNPADLHLSIASASSHKNIFSGLDV--------------FSNVFHGPST-TLRD------- 333

  Fly  1247 RLQQARRGIDMSGTKDHDDMNRLIS----ASLQRIRLERQPATPGISATKEEDRLSNRGSISSAN 1307
                          ::||..||...    |..:.::.:|.    |:..|.....||:..|.:|.|
pombe   334 --------------REHDMRNRSFDHSTLAHYEAVKQQRL----GVEPTARSFTLSSYKSRASGN 380

  Fly  1308 SFASAHNYELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPETELDAATRAKFYQLL 1372
            |..:..                       |..|....:..::.||:...:      .|.:.|..|
pombe   381 SLINDR-----------------------SSTTTPTFVNSEASSPVHKNK------RRRRIYAAL 416

  Fly  1373 VDATLAEIEHSTHMDQTLGTDSEHHYESIRHSGDPIYEEIHEVPPPLPLSAPPLNDAELEKKAAR 1437
            :....:|:                                        |....|.|...:.....
pombe   417 LSRVASEL----------------------------------------LDRLQLGDITKDGLIYS 441

  Fly  1438 SIFEGASKYDILSYLVDAKERGLA-------------REESFDY---------------GNNPKI 1474
            :.|.|.....:|..::...:|.||             .:.::|:               |..|.:
pombe   442 NAFTGDHAVTVLMGIIHTSDRNLALLVGRSLDAQKFIHDVTYDHRLRDSHREIYQLQGTGYRPFL 506

  Fly  1475 IEEEAADTLSDLDKRQAEERERDRDSG-QSSMSSL-----------------SP------PPHNF 1515
               .|.|..|..:|...:|.| |.:|| :.|.|:|                 ||      |.::.
pombe   507 ---RANDNASINNKNHHKELE-DNESGTRISPSTLGDTSFPNGIFTLLTHCYSPTCAKDHPCYSI 567

  Fly  1516 ICGGAGKSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVC 1580
            .|       ...:|:|........:.|.:|...|       .:|.:..:.:......|.|:
pombe   568 SC-------PRRLEQQHRLFAKMRANTEQSSSLA-------FDDKEQKLWIHSVPQEIAYS---- 614

  Fly  1581 RKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQ----LSAIFLNTEDLL 1641
              ...:..:|:|:|.|::.||..:.:||:.:.:.:..|:..:..:.:.:    :..:|||..::.
pombe   615 --VSDRERKRQEVICEVIYTERDFVKDLEYLRDYWIKPLWASSCIPERKKEKFIRTVFLNALEVQ 677

  Fly  1642 ENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLA--NLEK 1704
            ..|..|||.:       .::.:...:..||..|||:.......|..|     ||..|..  ..||
pombe   678 AVNSKLAEAL-------TKRQNYKPIVDNIADIFLEHVPKFEPFIRY-----GAGQLYGKYEFEK 730

  Fly  1705 EKELLRIFLK-VSQMEN-AVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEG-------- 1759
            ||.....|.| ||.:|. ...|::.||.:|..|..|:.:|||||..:.|.|.   ||
pombe   731 EKSSNPAFAKFVSDVERLKESRKLELNGYLTKPTTRLARYPLLLEAVLKYTD---EGNPDKQDIP 792

  Fly  1760 -----------RELLKQAQEKIELHLNHINQEAKDVPTKLW--------RRISSSSPNRRASCEI 1805
                       |..::..:.:.:.:|.|:||:....|.:.:        |::....|
pombe   793 KVINIVRGFLSRLNVESGKAENKFNLFHLNQQLVFKPGEHYDLHLLDANRQLIFKGP-------- 849

  Fly  1806 DMINIKLRKMAIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLV------TNG 1864
                :|.|.......|...|...|..:..||..:|...|.::...:...|:..||:      .||
pombe   850 ----LKKRSAGSTSSESASDVTLFLFDHALLIVKPKTINKRELLKVFQRPIPLLLLQLFLVDDNG 910

  Fly  1865 K--PSANYRAEKAMSEKLNFPKHTGIREASLLLVKEKCGRYTLIREPLYLDRCVVCSEADWDDYF 1927
            .  |.::.:...|:|:..|....:.....||.|:..:....||          ...:|...|.:.
pombe   911 LRIPYSSKQQLAAVSKAANGKPPSRFYPFSLQLLGRRGYEITL----------YATTEVSRDKWL 965

  Fly  1928 EVQEISSKDTFIFKAEDGVRTKQWY 1952
            |  .|.::.|.:      ....||:
pombe   966 E--HIDNQQTLL------QHRNQWF 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	51/212 (24%)
rgf1	NP_588116.1	ROM1	6..1320	CDD:227709	236/1260 (19%)
		DEP_fRom2	416..497	CDD:239882	12/120 (10%)
		RhoGEF	625..806	CDD:279015	49/195 (25%)
		PH_5	844..972	CDD:292048	28/151 (19%)
		CNH	1004..1290	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.800