DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF64C and ARHGEF18

DIOPT Version :9

Sequence 1:NP_001261425.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_005272521.1 Gene:ARHGEF18 / 23370 HGNCID:17090 Length:1426 Species:Homo sapiens


Alignment Length:1129 Identity:221/1129 - (19%)
Similarity:387/1129 - (34%) Gaps:345/1129 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   922 KGLEPLPHEINKSPLSP-------QRTVVRVAPFKPQQQQ-VGGSGDGFTHEVHRLKISHSEED- 977
            :|.||      ||.:.|       ..|......:||:... ....||....:..| ::|.|.|| 
Human    28 RGSEP------KSCVQPFDSGAVASATKSSSGSWKPENPDFFSAMGDDQEDDFPR-RLSESMEDL 85

  Fly   978 -------------ADLGVELRRRPNLFLSSPGE-EDAAPKKTSILISGDDCYSTM----NLSANA 1024
                         .|||:.....     |.||| .|:.|  |......|..:|::    :||...
Human    86 SLDLGALQGSEYLQDLGLGAPSH-----SQPGETPDSRP--TGEEPGRDSLFSSLAGSQDLSRRR 143

  Fly  1025 AQPLYQSSVVVNSHSATSVCISVSSAEEQEQELNQLNTLRSQQMGMGIAIIPIRGASEVNLQRSV 1089
            :....:|.    |.|...:.:..|:.:|:......|.:|.....|.|:.            ..:.
Human   144 SWERSRSC----SESWRRLSLDASAVDEEPCLPRTLASLALNLPGGGLK------------TWTQ 192

  Fly  1090 SCISSTSSSSTSSSSSSSGRGRTLIRLDYDRERKGSATSSTPINTPPVISSTPATPPPTDLPIEN 1154
            .|:|...:.:.|...            :.|..:|...:.|.|::...:.|  |...|..::|   
Human   193 GCLSGGGTPAESPGK------------ECDSPKKRGRSRSVPVSFYEIRS--PEISPGLEVP--- 240

  Fly  1155 ANPLVPHETELLKILRNPVEAVKLNLVPHVCGLRAPTRESGKSKKIQEEEVSGTPVKDPGFIAKL 1219
                                      .|.|.||..|..|..:...::.:.|.             
Human   241 --------------------------TPPVQGLEPPVLECMEKDHVEPDHVL------------- 266

  Fly  1220 LQDPMLGQVAEGLETETVAELIENSLQRLQQ---ARRGIDMSGTKDHDDMNRLISASLQRIRLER 1281
                                :::..||.|:|   ||:...||                       
Human   267 --------------------IVQQVLQELRQYHGARQRACMS----------------------- 288

  Fly  1282 QPATPGISATKEEDRLSNRGSISSANSFASAH-NYELFDF----DGGAGGNE-SDCYQSCSSELT 1340
              |:||                       .|| |...|:|    :.|||.|| ||...|....|:
Human   289 --ASPG-----------------------GAHSNLTWFEFLSESEDGAGKNEKSDKSTSVKRRLS 328

  Fly  1341 A--SGIL--EEDSVSP--IKDPETELDAATRAKFYQLLVDATLAEIEHSTHMDQTLGTDSEHHYE 1399
            .  |.:.  :|...||  :||.                                  |.|:....|
Human   329 CLRSRVTRQKEKGKSPAHLKDK----------------------------------GQDARERRE 359

  Fly  1400 SIRHSGDPIYEEIHEVPPPLPLSAPP-LNDAELEKKAARSIFEGASKYDILSYLVDAKERGLARE 1463
            .:  :|..:.:.....|...||...| |:.|.|::....::....|         .|..|.:...
Human   360 CV--NGHQLLQGTFSGPSSCPLCGKPFLSSASLKEHPRGTLLSDGS---------PALSRNVGMT 413

  Fly  1464 ESFDYGNNPKIIEEEAADTLSDLDKRQAEERERD------RDSGQSSMSSLSPPPHN-FICGGAG 1521
            .|...|..|   ....|...:.|.....|..|.|      :.:...|:|..||...: |:.....
Human   414 VSQKGGPQP---TPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVEDPYT 475

  Fly  1522 KSSGSDVERQDSGVGSETSKTSRSKYQATPTVLHLCEDCDGAVEMQVGDNGILYAPLVCRKCGKK 1586
            .|..|::|..    |.|....|.|          |..|.             .||    :|..::
Human   476 ASLRSEIESD----GHEFEAESWS----------LAVDA-------------AYA----KKQKRE 509

  Fly  1587 RVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERM 1651
            .|:|::::.|:::||..:.|.|:|:|:.:...:......:.:.:..:|...:||||.:.....|:
Human   510 VVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARL 574

  Fly  1652 RDALDMSLEQGDD-DLLTVNIGRIFL-DFT-----QMLHAFESYCVRQAGASLLLAN----LEKE 1705
            ::....|||:|.| :.:...||.:.: .|:     :|...:..:|   :|.:..:::    |::.
Human   575 KERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFC---SGHNEAVSHYKLLLQQN 636

  Fly  1706 KELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKI 1770
            |:...:..|:...  :::||:.:...:::..||:||||:|:.|:.:.|.:..|..|.|.||...|
Human   637 KKFQNLIKKIGNF--SIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLI 699

  Fly  1771 ELHLNHIN---------QEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLRKMAID-VLEWN-- 1823
            :..::.::         |..:::..|:..:.||...|.....:.||:.   |::.:: :|.|.  
Human   700 KDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQ---RQLHLEGMLCWKTT 761

  Fly  1824 ----HDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAM---SEKLN 1881
                .|.:...:...||..|..|..:..|......||.:|.....:..||  .||||   |..|.
Human   762 SGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVAN--EEKAMFLISASLQ 824

  Fly  1882 FPK----HTGIRE------ASLLLVKEKC-----GRYTLIREPLYLDRCVVCSEADWDDYFEVQE 1931
            .|:    :|..:|      |.:....|.|     |.::|..|    :|.||.:.|.....|: :.
Human   825 GPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEE----ERKVVEARATRLRDFQ-ER 884

  Fly  1932 ISSKDTFIFKAEDGVRTKQWYTQL 1955
            :|.||..|  |:..:..:|.|.::
Human   885 LSMKDQLI--AQSLLEKQQIYLEM 906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_001261425.1 RhoGEF 1593..1779 CDD:279015 44/205 (21%)
ARHGEF18XP_005272521.1 RhoGEF 513..707 CDD:238091 45/198 (23%)
PH_ARHGEF18 747..865 CDD:275437 28/122 (23%)
PH <786..851 CDD:278594 16/66 (24%)
DUF2570 1061..1156 CDD:305162
PKK 1086..1193 CDD:289257
DUF4200 1111..>1190 CDD:290574
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6371
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.760

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