Protein Alignment RhoGEF64C and Arhgef16

DIOPT Version :9

• Sequence 1: NP_001261425.1
• Gene: RhoGEF64C / 38578
• FlyBaseID: FBgn0035574
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_011248543.1
• Gene: Arhgef16 / 230972
• MGIID: 2446219
• Length: 721
• Species: Mus musculus
• Alignment Length: 669
• Identity: 128/669 - (19%)
• Similarity: 218/669 - (32%)
• Gaps: 206/669 - (30%)

  Fly  1416 PPPLPLSAPPLNDAELEKKAARSIFEGASKY--DILSYLVDAKERGLAREESFDYGNNPKIIEEE 1478
            |||.|....|.....|..::..::..|..:.  ..|:....||.:..||.:||    ...::.:|
Mouse    68 PPPSPEDEEPPRPIVLSTQSPAALKMGTQQLIPKSLAVASKAKTKSPARHQSF----GAAVLSKE 128

  Fly  1479 AAD-----------TLSDLDKRQAE----ERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDV 1528
            ||.           :|.|:|.....    .|.....|.:::|....||          .|.|..|
Mouse   129 AARRNPQLFSAPSFSLDDMDMDMVTTGNLRRNLRNQSYRAAMKGPGPP----------SSKGDSV 183

  Fly  1529 E-------------RQDSGVGSETSKT------SRSKYQATPTVLH----------------LCE 1558
            :             :..|...::..||      .:..::..|.:..                :.:
Mouse   184 QLGPKLQALAEEAAQPPSRYPAKNKKTLGRKRAHKGSFKDDPQLYQEIRERGLNTSHESDDDILD 248

  Fly  1559 DCDGAVEMQVGDNGIL---YAPL--------------VCRKCGKKRVERKEIITEIVETEEKYGR 1606
            :..|.|..|..|..|:   |.|.              |......:..:|:|.|.||:.:|..|..
Mouse   249 EPSGPVGTQRADTTIVVKSYRPAQLTWSQLPEVLESGVLDTLSTEERKRQEAIFEILTSEFSYLH 313

  Fly  1607 DLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQTLAERMRDALDMSLEQGDDDLLTV-N 1670
            .|.|::.||.....:...:||.:...:|.|..|::..:|...|        :|||.....:.| :
Mouse   314 SLSILVTEFLQSRELRATMTQTEHHHLFSNILDVMSASQKFFE--------ALEQRHKAQVCVED 370

  Fly  1671 IGRIFLDFTQ-MLHAFESYCVRQAGASLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMV 1734
            |..|..|..| ..|.:.:||..:......|..|.......|..||..:...| ...:.:.|||::
Mouse   371 ISDILEDHAQHHFHPYIAYCSNEVYQQRTLQKLSNSNAAFRDVLKEIEKRPA-CGGLPMISFLIL 434

  Fly  1735 PVQRVTKYPLLLARLYKVTPSHLEGRELLKQAQEKIELHLNHINQEA------------------ 1781
            |:||||:.|||...|...|..|.|..:...||.:.|...:...|:.|
Mouse   435 PMQRVTRLPLLTDTLCLKTQGHPERYKAASQALKAISKLVKQCNEGAHKMERTEQIYTLNMQLDF 499

  Fly  1782 ---KDVP-------------------TKLWRRISSSSPNRRASCEI----DMINIKLRK-----M 1815
               |.:|                   :.::|:|:|     |.:|.:    |::.:..:|     :
Mouse   500 GKVKSLPLISASRWLLKRGELFLLEESSIFRKIAS-----RPTCYLFLFNDVLVVTKKKSEESYL 559

  Fly  1816 AIDVLEWNHDEVRFAMEGRLLYTQPTDSNWKKARTIKLTPVNALLVTNGKPSANYRAEKAMSEKL 1880
            ..|..:.:|.:||                       ||.|...||     |..:.|     |..:
Mouse   560 VQDYAQLDHVQVR-----------------------KLEPSEPLL-----PGGSSR-----SSSV 591

  Fly  1881 NFPKHTGI------REASLLLVKEKCGRYTLIREPLYLDR-----CVVCSEADWD---DYFEVQE 1931
            .:|....:      |:..:||..:...           ||     .:...|..|.   :..|:.:
Mouse   592 PYPFQVNLLHNSEGRQEQILLSSDSAS-----------DRARWITALTYKERQWQGITNKGELPQ 645

  Fly  1932 ISSKDTFIFKAEDGVRTKQ 1950
            :.....:..|..|.:..:|
Mouse   646 VEVTKAYFAKQADEITLQQ 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF64C	NP_001261425.1	RhoGEF	1593..1779	CDD:279015	51/187 (27%)
Arhgef16	XP_011248543.1	RhoGEF	300..478	CDD:366202	51/186 (27%)
		PH_ephexin	501..634	CDD:269929	28/181 (15%)
		SH3_ARHGEF16_26	645..696	CDD:212871	3/20 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840