DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGEF64C and ARHGEF15

DIOPT Version :9

Sequence 1:NP_001261425.1 Gene:RhoGEF64C / 38578 FlyBaseID:FBgn0035574 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_011522036.1 Gene:ARHGEF15 / 22899 HGNCID:15590 Length:856 Species:Homo sapiens


Alignment Length:877 Identity:175/877 - (19%)
Similarity:305/877 - (34%) Gaps:258/877 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1140 STPATPPPTDLPIENANPLVPHETELLKILRNPVEAVKLNLVPHVCGLRAPTRESGKSKKIQEEE 1204
            |.||..|||..|.....|..|..:   :..::|               ..|...|...:..:...
Human     5 SLPAATPPTQKPPRIIRPRPPSRS---RAAQSP---------------GPPHNGSSPQELPRNSN 51

  Fly  1205 VSGTPVKDPGF---IAKLLQDPML---GQVAEGLETETVAELIENSLQRLQQARRGIDMSGTKDH 1263
            .:.||:..|.|   .|..|:.|.|   ......|:::|..:                ..|.|...
Human    52 DAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPD----------------SPSSTPTP 100

  Fly  1264 DDMNRLISASLQRI--------RLERQPATP-----GISATKEEDRLSNRGSISSANSFASAHNY 1315
            ..::|. |||.:..        :....|.||     |:        |:..||.|:..:...... 
Human   101 SPVSRR-SASPEPAPRSPVPPPKPSGSPCTPLLPMAGV--------LAQNGSASAPGTVRRLAG- 155

  Fly  1316 ELFDFDGGAGGNESDCYQSCSSELTASGILEEDSVSPIKDPETELDAATRAKFYQLLVDATLA-- 1378
               .|:|||.|...|. .:....|.|...:..:..:|:....::.:.|.         ||.||  
Human   156 ---RFEGGAEGRAQDA-DAPEPGLQARADVNGEREAPLTGSGSQENGAP---------DAGLACP 207

  Fly  1379 ----EIEHSTHMDQTLGTDSEHHYESIRHSGDPI--YEEIHEVPPPLPLSAPPLNDAELEKKAAR 1437
                .:.|:|.             ..:.....|:  |||:    |.:|..|.||..:. .:....
Human   208 PCCPCVCHTTR-------------PGLELRWVPVGGYEEV----PRVPRRASPLRTSR-SRPHPP 254

  Fly  1438 SIFEGASKYDILSYLVDAKERGL----------AREESFDYGNNPKIIEEEAADTLSDLDKRQAE 1492
            ||  |.....:.||...|:.:.|          .|:::..:|:.|:          .||| ..:|
Human   255 SI--GHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQ----------PDLD-LLSE 306

  Fly  1493 ERERDRDSGQSSMSSLSPPPHNFICGGAGKSSGSDVE-RQDSGV------GSETSKTSRSKYQAT 1550
            :..:..||...:..: :||              :.|| |::.|:      ..|........|| |
Human   307 DGIQTGDSPDEAPQN-TPP--------------ATVEGREEEGLEVLKEQNWELPLQDEPLYQ-T 355

  Fly  1551 PTVLHLCEDCDGAVE------MQVGDNGILYAPLVCRKCGKKRV--------------------E 1589
            .....|.|:..|..|      ...||     ||...|..|.:..                    |
Human   356 YRAAVLSEELWGVGEDGSPSPANAGD-----APTFPRPPGPRNTLWQELPAVQASGLLDTLSPQE 415

  Fly  1590 RK--EIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNTEDLLENNQ----TLA 1648
            |:  |.:.|:|.:|..|.|.|:::.:.|.....:...||......:|.|.:.:...::    ||.
Human   416 RRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLL 480

  Fly  1649 ERMRDALDMSLEQGDDDLLTV----NIG--RIFLDFTQ-MLHAFESYCVRQAGASLLLANLEKEK 1706
            .|:|.:..:|      ||..|    .:|  .:::|:.: ..:..|:|      :.|:..|:....
Human   481 SRVRSSPHIS------DLCDVVHAHAVGPFSVYVDYVRNQQYQEETY------SRLMDTNVRFSA 533

  Fly  1707 ELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEG---------REL 1762
            ||.|: ..:.:.|     |:.|.|||::|.||:|:..:||       ..|..|         :.:
Human   534 ELRRL-QSLPKCE-----RLPLPSFLLLPFQRITRLRMLL-------QGHRAGGPVTLPPCPQNI 585

  Fly  1763 LKQAQEKIELHLNHINQEAKDVPTKLWRRISSSSPNRRASCEIDMINIKLR---KMAIDVLEWNH 1824
            |:|.:|......|  .|:|....:|:..|.|:.....:.:.|:..:..:||   ..|:.::.|:.
Human   586 LRQTEEGSSRQEN--AQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSR 648

  Fly  1825 DEVRFAMEGRLLYTQPTDSNWKKARTI-----KLTPV------NALLVTNGKPSANYR------A 1872
               |...:|.|     |:...::...:     :.||:      :.||:|  :|.:..|      |
Human   649 ---RLEFQGEL-----TELGCRRGGVLFASRPRFTPLCLLLFSDLLLIT--QPKSGQRLQVLDYA 703

  Fly  1873 EKAMSEKLNFPKHTGIREASLLLVKEKCGRYT 1904
            .:::.:....|..:|.....|.|:....||.|
Human   704 HRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPT 735

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF64CNP_001261425.1 RhoGEF 1593..1779 CDD:279015 46/205 (22%)
ARHGEF15XP_011522036.1 RhoGEF 422..613 CDD:279015 49/217 (23%)
PH_ephexin 637..757 CDD:269929 21/109 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5422
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.930

Return to query results.
Submit another query.